(Q33337950)

25 July 2017

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title

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease (English)

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25 July 2017

0 references

Michael S Wolfe

1

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25 July 2017

publication date

1 December 2002

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International Immunopharmacology

25 July 2017

published in

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25 July 2017

volume

2

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25 July 2017

issue

13-14

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25 July 2017

page(s)

1919-1929

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https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

25 July 2017

1 reference

7 January 2021

Secretase targets for Alzheimer's disease: identification and therapeutic potential

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

The Role of presenilins in gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Biochemistry. Intramembrane proteases--mixing oil and water

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Gamma -secretase inhibitors repress thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

Presenilin-dependent gamma-secretase activity modulates thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2802%2900179-0

7 January 2021

10.1016/S1567-5769(02)00179-0

Identifiers

DOI

1 reference

25 July 2017

1 reference