(Q33412943)

26 July 2017

The role of apoptosis in megakaryocytes and platelets (English)

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26 July 2017

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Benjamin T Kile

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language of work or name

English

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publication date

28 January 2014

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British Journal of Haematology

26 July 2017

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26 July 2017

165

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26 July 2017

2

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26 July 2017

217-226

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Platelet apoptosis and apoptotic platelet clearance by macrophages in secondary dengue virus infections

26 July 2017

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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Anandamide extends platelets survival through CB(1)-dependent Akt signaling

21 January 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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Suppressive effects of anthrax lethal toxin on megakaryopoiesis

21 January 2018

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Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death

21 January 2018

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Thrombin activity and platelet microparticle formation are increased in type 2 diabetic platelets: a potential correlation with caspase activation

21 January 2018

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Platelet senescence and phosphatidylserine exposure

21 January 2018

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Platelet formation is the consequence of caspase activation within megakaryocytes

21 January 2018

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Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases.

21 January 2018

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The relation of blood platelets to hemorrhagic disease. By W.W. Duke.

21 January 2018

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THE RATE OF REGENERATION OF BLOOD PLATELETS.

21 January 2018

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Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

21 January 2018

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Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

21 January 2018

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Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

21 January 2018

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Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura

21 January 2018

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Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients.

21 January 2018

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

21 January 2018

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Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

21 January 2018

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XIAP discriminates between type I and type II FAS-induced apoptosis

21 January 2018

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

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BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation

21 January 2018

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The thrombocytopenia of cancer. Prospects for effective cytokine therapy

21 January 2018

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

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Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways

21 January 2018

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BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets

21 January 2018

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Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

21 January 2018

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Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL.

21 January 2018

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Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

21 January 2018

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Inflammasomes and their roles in health and disease

21 January 2018

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Apoptosis in the anucleate platelet

21 January 2018

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

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Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

21 January 2018

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Programmed anuclear cell death delimits platelet life span.

21 January 2018

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A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

21 January 2018

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Platelet Economy (Platelet Survival and Turnover)*

21 January 2018

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Role of CD61+ cells in thrombocytopenia of dengue patients

21 January 2018

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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Early increase in DcR2 expression and late activation of caspases in the platelet storage lesion

21 January 2018

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Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

21 January 2018

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Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

21 January 2018

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Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

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Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers

21 January 2018

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Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

21 January 2018

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Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

21 January 2018

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 January 2018

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Collection, preservation and transfusion of platelets; with special reference to the factors affecting the survival rate and the clinical effectiveness of transfused platelets

21 January 2018

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Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis

21 January 2018

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 January 2018

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Many stimuli pull the necrotic trigger, an overview

21 January 2018

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BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

21 January 2018

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Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors

21 January 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

21 January 2018

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

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Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

21 January 2018

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Platelet apoptosis in paediatric immune thrombocytopenia is ameliorated by intravenous immunoglobulin

21 January 2018

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zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway.

21 January 2018

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Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia

21 January 2018

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P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection

21 January 2018

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

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The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

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Impaired survival of bone marrow GPIIb/IIa+ megakaryocytic cells as an additional pathogenetic mechanism of HIV-1-related thrombocytopenia

21 January 2018

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Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

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P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.

21 January 2018

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Membrane asymmetry and blood coagulation

21 January 2018

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Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

21 January 2018

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Determination of the Life of Human Blood Platelets using Labelled Diisopropylfluorophosphonate

21 January 2018

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Functional expression of TRAIL and TRAIL-R2 during human megakaryocytic development

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/BJH.12757

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26 July 2017

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PubMed ID

24467740