(Q33413970)

26 July 2017

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways (English)

1 reference

26 July 2017

Michael J White

5

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Simon Preston

Simon P Preston

9

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Emma C Josefsson

Emma C Josefsson

1

0 references

Benjamin T. Kile

Benjamin T Kile

14

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Andreas Strasser

Andreas Strasser

13

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Marc Pellegrini

Marc Pellegrini

11

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Donald Metcalf

12

Donald Metcalf

1 reference

26 July 2017

Deborah L Burnett

2

1 reference

26 July 2017

Marion Lebois

3

1 reference

26 July 2017

Marlyse A Debrincat

4

1 reference

26 July 2017

Katya J Henley

6

1 reference

26 July 2017

Rachael M Lane

7

1 reference

26 July 2017

Diane Moujalled

8

1 reference

26 July 2017

Lorraine A O'Reilly

10

1 reference

26 July 2017

language of work or name

English

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publication date

17 March 2014

1 reference

26 July 2017

Nature Communications

1 reference

26 July 2017

5

1 reference

26 July 2017

3455

1 reference

https://scigraph.springernature.com/pub.10.1038/ncomms4455

26 July 2017

0 references

cites work

Cell biology. Beyond clotting: the powers of platelets

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

The incredible journey: From megakaryocyte development to platelet formation.

21 January 2018

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The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4455

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Platelet formation is the consequence of caspase activation within megakaryocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Management of chemotherapy-induced thrombocytopenia: current status of thrombopoietic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Impaired survival of bone marrow GPIIb/IIa+ megakaryocytic cells as an additional pathogenetic mechanism of HIV-1-related thrombocytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Role of CD61+ cells in thrombocytopenia of dengue patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Suppressive effects of anthrax lethal toxin on megakaryopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Programmed anuclear cell death delimits platelet life span.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

XIAP discriminates between type I and type II FAS-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Lethal effect of the anti-Fas antibody in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Caspase signalling controls microglia activation and neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Caspase 3 activity is required for skeletal muscle differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Caspase knockouts: matters of life and death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Translating insights from persistent LCMV infection into anti-HIV immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Aggravation of viral hepatitis by platelet-derived serotonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Caspase activation is involved in early megakaryocyte differentiation but not in platelet production from megakaryocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Platelet apoptosis and apoptotic platelet clearance by macrophages in secondary dengue virus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

The renaissance of interferon therapy for the treatment of myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Observation of Antigen-Dependent CD8+ T-Cell/ Dendritic Cell Interactions in Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Platelet Life Span and Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

Functional expression of TRAIL and TRAIL-R2 during human megakaryocytic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

The role of apoptosis in megakaryocytes and platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

7 January 2021

Bcl-2 family proteins are essential for platelet survival.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

7 January 2021

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

7 January 2021

Broad-spectrum caspase inhibitors: from myth to reality?

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

7 January 2021

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4455

7 January 2021

Identifiers

DOI

10.1038/NCOMMS4455

1 reference

Dimensions Publication ID

26 July 2017

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1 reference