(Q33548213)

28 July 2017

1 reference

title

Structural and energetic determinants of the S1-site specificity in serine proteases (English)

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28 July 2017

H Czapinska

1

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28 July 2017

J Otlewski

series ordinal

2

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28 July 2017

language of work or name

English

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publication date

1 March 1999

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28 July 2017

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28 July 2017

volume

260

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28 July 2017

issue

3

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28 July 2017

page(s)

571-595

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Evolution of Proteolytic Enzymes

28 July 2017

cites work

1 reference

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Unique fold and active site in cytomegalovirus protease

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21 January 2018

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21 January 2018

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Crystal structure of a catalytic antibody with a serine protease active site

21 January 2018

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The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7 A resolution

21 January 2018

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Subtilases: the superfamily of subtilisin-like serine proteases

21 January 2018

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The high-resolution X-ray crystal structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis. Structural analysis, subtilisin structure and interface geometry

21 January 2018

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Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo

21 January 2018

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Crystal and molecular structure of chymotrypsin inhibitor 2 from barley seeds in complex with subtilisin Novo

21 January 2018

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A protein-folding reaction under kinetic control

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Pro-sequence of subtilisin can guide the refolding of denatured subtilisin in an intermolecular process.

21 January 2018

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The prosegment-subtilisin BPN' complex: crystal structure of a specific 'foldase'

21 January 2018

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Protein memory through altered folding mediated by intramolecular chaperones.

21 January 2018

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Structural basis for broad specificity in alpha-lytic protease mutants

21 January 2018

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Relocating a negative charge in the binding pocket of trypsin

21 January 2018

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Random mutagenesis of the substrate-binding site of a serine protease can generate enzymes with increased activities and altered primary specificities

21 January 2018

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A genetic selection elucidates structural determinants of arginine versus lysine specificity in trypsin

21 January 2018

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Selection of Streptomyces griseus protease B mutants with desired alterations in primary specificity using a library screening strategy

21 January 2018

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A glutamic acid specific serine protease utilizes a novel histidine triad in substrate binding

21 January 2018

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Novel features of serine protease active sites and specificity pockets: sequence analysis and modelling studies of glutamate-specific endopeptidases and epidermolytic toxins.

21 January 2018

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Conservation and variability in the structures of serine proteinases of the chymotrypsin family

21 January 2018

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Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

21 January 2018

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Three-dimensional, sequence order-independent structural comparison of a serine protease against the crystallographic database reveals active site similarities: potential implications to evolution and to protein folding

21 January 2018

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Comparative modeling methods: application to the family of the mammalian serine proteases

21 January 2018

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Free energy calculations on binding and catalysis by alpha-lytic protease: the role of substrate size in the P1 pocket

21 January 2018

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Protein inhibitors of proteinases

21 January 2018

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Natural protein proteinase inhibitors and their interaction with proteinases

21 January 2018

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Inhibition of subtilisin BPN' by reaction site P1 mutants of Streptomyces subtilisin inhibitor

21 January 2018

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Specificity of human cathepsin G.

21 January 2018

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Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors

21 January 2018

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Crystallographic study of the binding of a trifluoroacetyl dipeptide anilide inhibitor with elastase

21 January 2018

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The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor

21 January 2018

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Electrostatic complementarity within the substrate-binding pocket of trypsin

21 January 2018

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Substrate specificity of trypsin investigated by using a genetic selection

21 January 2018

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The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor

21 January 2018

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Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 Å resolution

21 January 2018

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Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin

21 January 2018

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Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser

21 January 2018

1 reference

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The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

21 January 2018

1 reference

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Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Specificity determinants of rat tissue kallikrein probed by site-directed mutagenesis

21 January 2018

1 reference

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Determinants of the unusual cleavage specificity of lysyl-bradykinin-releasing kallikreins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins

21 January 2018

1 reference

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Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structure-based design of a potent chimeric thrombin inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structure of human des(1-45) factor Xa at 2.2 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

X-ray structure of antistasin at 1.9 A resolution and its modelled complex with blood coagulation factor Xa

21 January 2018

1 reference

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The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa

21 January 2018

1 reference

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X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

21 January 2018

1 reference

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X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Specificity of activated human protein C.

21 January 2018

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The crystal structure of the catalytic domain of human urokinase-type plasminogen activator

21 January 2018

1 reference

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The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator

21 January 2018

1 reference

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Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

21 January 2018

1 reference

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Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage

21 January 2018

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Origins of the specificity of tissue-type plasminogen activator

21 January 2018

1 reference

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Identification of a hydrophobic exosite on tissue type plasminogen activator that modulates specificity for plasminogen.

21 January 2018

1 reference

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Converting tissue-type plasminogen activator into a zymogen.

21 January 2018

1 reference

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Converting tissue type plasminogen activator into a zymogen. Important role of Lys156.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structural basis of the activation and action of trypsin

21 January 2018

1 reference

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Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The specificity of chymotrypsin. A statistical analysis of hydrolysis data

21 January 2018

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Ecotin: lessons on survival in a protease-filled world

21 January 2018

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Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities

21 January 2018

1 reference

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Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Mammalian membrane-bound adenylyl cyclases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Converting trypsin to chymotrypsin: the role of surface loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structural origins of substrate discrimination in trypsin and chymotrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Delocalizing trypsin specificity with metal activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester s

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The polymorphonuclear leukocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Substrate and inhibitor studies on proteinase 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Designing substrate specificity by protein engineering of electrostatic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Designing Subtilisin BPN' To Cleave Substrates Containing Dibasic Residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Furilisin: a variant of subtilisin BPN' engineered for cleaving tribasic substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Hydrogen bonding and biological specificity analysed by protein engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structural plasticity broadens the specificity of an engineered protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Characterization of the S1 binding site of the glutamic acid-specific protease from Streptomyces griseus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Hepatitis A virus 3C proteinase substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

New enzyme lineages by subdomain shuffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structure of HBP, a multifunctional protein with a serine proteinase fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The molecular environment of the Na+ binding site of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

The structure of rat mast cell protease II at 1.9-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Refined crystal structure of Streptomyces griseus trypsin at 1.7 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Engineering cyclophilin into a proline-specific endopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

Substance P regulates the vasodilator activity of calcitonin gene-related peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.1999.00160.X

10.1046/J.1432-1327.1999.00160.X

21 January 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference