(Q33570085)

28 July 2017

title

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. (English)

1 reference

28 July 2017

0 references

Charlotte Ling

5

0 references

Donald W Bowden

3

object named as

Donald W Bowden

1 reference

28 July 2017

Philippe A Halban

1

1 reference

28 July 2017

Kenneth S Polonsky

2

1 reference

28 July 2017

Meredith A Hawkins

4

1 reference

28 July 2017

Kieren J Mather

6

1 reference

28 July 2017

Alvin C Powers

7

1 reference

28 July 2017

Christopher J Rhodes

8

1 reference

28 July 2017

Lori Sussel

9

1 reference

28 July 2017

Gordon C Weir

10

1 reference

28 July 2017

language of work or name

English

0 references

publication date

8 April 2014

1 reference

The Journal of Clinical Endocrinology and Metabolism

28 July 2017

published in

1 reference

28 July 2017

volume

99

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28 July 2017

issue

6

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28 July 2017

page(s)

1983-1992

1 reference

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

28 July 2017

cites work

1 reference

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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

21 June 2018

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Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

21 June 2018

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21 June 2018

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21 June 2018

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Inactivation of specific β cell transcription factors in type 2 diabetes

21 June 2018

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Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.

21 June 2018

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21 June 2018

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21 June 2018

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Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

21 June 2018

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Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

21 June 2018

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21 June 2018

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21 June 2018

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Gastric bypass and banding equally improve insulin sensitivity and β cell function

21 June 2018

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21 June 2018

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A multisite study of long-term remission and relapse of type 2 diabetes mellitus following gastric bypass.

21 June 2018

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Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

21 June 2018

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Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: how markers of β-cell loss may assist.

21 June 2018

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The genetic and epigenetic basis of type 2 diabetes and obesity

21 June 2018

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Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

21 June 2018

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21 June 2018

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Imaging of β-cell mass and insulitis in insulin-dependent (Type 1) diabetes mellitus

21 June 2018

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Formation of a human β-cell population within pancreatic islets is set early in life

21 June 2018

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Effects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity

21 June 2018

1 reference

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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

21 June 2018

1 reference

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Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

21 June 2018

1 reference

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DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

21 June 2018

1 reference

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Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules

21 June 2018

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Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of type 2 diabetes.

21 June 2018

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Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes

21 June 2018

1 reference

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Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog

21 June 2018

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Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial

21 June 2018

1 reference

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Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

21 June 2018

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Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

21 June 2018

1 reference

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Type 2 diabetes as an inflammatory disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Nationwide cohort study of post-gastric bypass hypoglycaemia including 5,040 patients undergoing surgery for obesity in 1986-2006 in Sweden

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Genome-wide analysis of histone modifications in human pancreatic islets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Finding the missing heritability of complex diseases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Glucolipotoxicity of the pancreatic beta cell.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Minireview: Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

miR-375 maintains normal pancreatic alpha- and beta-cell mass

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Five stages of evolving beta-cell dysfunction during progression to diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

A pancreatic islet-specific microRNA regulates insulin secretion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Diabetes in old male offspring of rat dams fed a reduced protein diet.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies

21 June 2018

1 reference

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Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study

31 October 2018

1 reference

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The stunned beta cell: a brief history

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Islets in type 2 diabetes: in honor of Dr. Robert C. Turner

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Pancreatic beta-cell mass in European subjects with type 2 diabetes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.

31 October 2018

1 reference

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Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Parental transmission of type 2 diabetes: the Framingham Offspring Study

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Are we overestimating the loss of beta cells in type 2 diabetes?

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393482

Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery

31 October 2018

1 reference

12 December 2020

Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes

1 reference

12 December 2020

Metabolic surgery for type 2 diabetes

1 reference

12 December 2020

Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes

1 reference

12 December 2020

Identifiers

DOI

10.1210/JC.2014-1425

1 reference

28 July 2017

1 reference

28 July 2017

1 reference