(Q33621850)

28 July 2017

1 reference

title

The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease (English)

1 reference

28 July 2017

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5

Kazuhiro Irie

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28 July 2017

Kazuma Murakami

1

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28 July 2017

Yuichi Masuda

series ordinal

2

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28 July 2017

Takuji Shirasawa

series ordinal

3

1 reference

28 July 2017

Takahiko Shimizu

series ordinal

4

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28 July 2017

publication date

1 July 2010

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Geriatrics and Gerontology International

28 July 2017

published in

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28 July 2017

volume

10 Suppl 1

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28 July 2017

page(s)

S169-79

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

28 July 2017

cites work

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21 January 2018

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

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Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein

21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

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Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

21 January 2018

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

21 January 2018

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Biological significance of isoaspartate and its repair system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Structural and kinetic features of amyloid beta-protein fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Alzheimer's amyloid fibrils: structure and assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Amyloid fibrils may be assembled from beta-helical protofibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

A molecular model of Alzheimer amyloid beta-peptide fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Molecular structure of amyloid fibrils: insights from solid-state NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

The metallobiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Neurodegenerative diseases and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Amyloid &#946;-Peptide [1-42]-Associated Free Radical-Induced Oxidative Stress And Neurodegeneration in Alzheimers Disease Brain: Mechanisms and Consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

N-Terminal deletions modify the Cu2+ binding site in amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Amyloidosis of Alzheimer's Abeta peptides: solid-state nuclear magnetic resonance, electron paramagnetic resonance, transmission electron microscopy, scanning transmission electron microscopy and atomic force microscopy studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Early onset familial Alzheimer's disease: Mutation frequency in 31 families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta(1--42) and A beta(25--35).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Substitution of isoleucine-31 by helical-breaking proline abolishes oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Toxicity of Dutch (E22Q) and Flemish (A21G) mutant amyloid beta proteins to human cerebral microvessel and aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

The Arctic mutation interferes with processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Identification of an isoaspartyl linkage formed upon deamidation of bovine calbindin D9k and structural characterization by 2D 1H NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Identification of physiological and toxic conformations in Abeta42 aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1447-0594.2010.00598.X

10.1111/J.1447-0594.2010.00598.X

21 January 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference