(Q33853600)

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Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM.

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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7

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Garth Powis

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Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Yong-Wan Kim

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Ta Jen Liu

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Dimpy Koul

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Ningyi Tiao

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Abdullah H Feroze

5

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Jing Wang

6

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Europe PubMed Central

PubMed publication ID

29 July 2017

W K Alfred Yung

8

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Europe PubMed Central

PubMed publication ID

29 July 2017

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publication date

1 April 2011

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Europe PubMed Central

PubMed publication ID

29 July 2017

13

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Europe PubMed Central

PubMed publication ID

29 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

367-375

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Synthetic lethality--a new direction in cancer-drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Exploring multi-targeting strategies for the treatment of gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Neurooncology clinical trial design for targeted therapies: lessons learned from the North American Brain Tumor Consortium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

New molecular targets in malignant gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Utilizing RNA interference to enhance cancer drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Genome-wide functional analysis of human cell-cycle regulators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Building mammalian signalling pathways with RNAi screens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

The concept of synthetic lethality in the context of anticancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Estimating the occurrence of false positives and false negatives in microarray studies by approximating and partitioning the empirical distribution of p-values

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Expression profiling reveals off-target gene regulation by RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Nonprimate lentiviral vectors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Genetic synthetic lethality screen at the single gene level in cultured human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064700

5 July 2018

Erlotinib in gliomas: should selection be based on EGFR and Akt analyses?

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOR012

21 January 2018

Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOR012

21 January 2018

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOR012

21 January 2018

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOR012

21 January 2018

Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOR012

21 January 2018

High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21430111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lethal combinations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21430111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21430111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR inhibitors in the treatment of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21430111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NEUONC/NOR012

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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