(Q33991720)

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The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.

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14 March 2020

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells (English)

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14 March 2020

Parkinson's disease

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based on heuristic

inferred from title

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based on heuristic

inferred from title

3

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14 March 2020

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14 March 2020

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Aaron D Gitler

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14 March 2020

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Janice L Holton

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14 March 2020

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Mohamed-Bilal Fares

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14 March 2020

Nadine Ait-Bouziad

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14 March 2020

Martial K Mbefo

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14 March 2020

Ana Jovičić

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Aoife Kiely

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14 March 2020

David Eliezer

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14 March 2020

Hilal A Lashuel

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11 April 2014

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14 March 2020

Human Molecular Genetics

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14 March 2020

4491-4509

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14 March 2020

describes a project that uses

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

Alpha-synuclein mRNA expression in oligodendrocytes in MSA.

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Alpha-synuclein transfers from neurons to oligodendrocytes

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5 July 2018

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

1 reference

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5 July 2018

The function of α-synuclein

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5 July 2018

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

1 reference

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5 July 2018

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome

1 reference

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5 July 2018

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

1 reference

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5 July 2018

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

1 reference

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5 July 2018

Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.

1 reference

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5 July 2018

Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress

1 reference

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5 July 2018

The many faces of α-synuclein: from structure and toxicity to therapeutic target

1 reference

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5 July 2018

α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies

1 reference

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5 July 2018

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1 reference

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5 July 2018

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

1 reference

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5 July 2018

Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

1 reference

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5 July 2018

Determining nuclear localization of alpha-synuclein in mouse brains

1 reference

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5 July 2018

Folding and misfolding of alpha-synuclein on membranes.

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5 July 2018

E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment

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5 July 2018

Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease.

1 reference

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5 July 2018

Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation

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5 July 2018

The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding

1 reference

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5 July 2018

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

1 reference

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5 July 2018

Sensitive and specific detection of α-synuclein in human plasma

1 reference

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5 July 2018

The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms

1 reference

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5 July 2018

Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy

1 reference

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5 July 2018

Phosphorylation of synucleins by members of the Polo-like kinase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119404

5 July 2018

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

1 reference

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5 July 2018

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119404

5 July 2018

Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119404

5 July 2018

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

1 reference

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5 July 2018

alpha-Synuclein and neuronal cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119404

5 July 2018

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

1 reference

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5 July 2018

A bright and photostable photoconvertible fluorescent protein

1 reference

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5 July 2018

Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement

1 reference

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5 July 2018

Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells

1 reference

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5 July 2018

Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody

1 reference

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5 July 2018

Clearance and deposition of extracellular alpha-synuclein aggregates in microglia.

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5 July 2018

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

1 reference

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5 July 2018

Determination of alpha-synuclein concentration in human plasma using ELISA.

1 reference

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5 July 2018

Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody

1 reference

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5 July 2018

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

1 reference

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5 July 2018

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

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5 July 2018

Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells

1 reference

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5 July 2018

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

1 reference

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5 July 2018

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

1 reference

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5 July 2018

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

1 reference

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5 July 2018

Structure and dynamics of micelle-bound human alpha-synuclein

1 reference

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5 July 2018

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

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5 July 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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5 July 2018

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

1 reference

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5 July 2018

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

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5 July 2018

alpha-synuclein aggregation: a link between mitochondrial defects and Parkinson's disease?

1 reference

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5 July 2018

A broken alpha -helix in folded alpha -Synuclein

1 reference

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5 July 2018

Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD

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5 July 2018

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

1 reference

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5 July 2018

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

1 reference

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5 July 2018

A method for efficient isotopic labeling of recombinant proteins

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5 July 2018

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 reference

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5 July 2018

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

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5 July 2018

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1 reference

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5 July 2018

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

1 reference

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5 July 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

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5 July 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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5 July 2018

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

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5 July 2018

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

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5 July 2018

Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments

1 reference

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5 July 2018

Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

1 reference

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5 July 2018

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

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5 July 2018

Conformational properties of alpha-synuclein in its free and lipid-associated states

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21 January 2018

Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein.

1 reference

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21 January 2018

The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro

1 reference

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21 January 2018

A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

1 reference

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21 January 2018

Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein

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21 January 2018

Spin-label EPR on alpha-synuclein reveals differences in the membrane binding affinity of the two antiparallel helices

1 reference

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21 January 2018

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

1 reference

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21 January 2018

Yeast cells provide insight into alpha-synuclein biology and pathobiology

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21 January 2018

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

1 reference

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21 January 2018

Subcellular localisation of recombinant alpha- and gamma-synuclein.

1 reference

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21 January 2018

Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice

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21 January 2018

Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein.

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21 January 2018

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD.

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21 January 2018

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.

1 reference

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21 January 2018

Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Immunolocalization of alpha-synuclein in the rat spinal cord by two novel monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Expression and subcellular location of alpha-synuclein during mouse-embryonic development.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Nuclear targeting of mutant Huntingtin increases toxicity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Nuclear localization of alpha-synuclein and its interaction with histones

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU165

21 January 2018

The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119404

29 October 2018

100 years of Lewy pathology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119404

29 October 2018

Alpha-synuclein is localized in a subpopulation of rat brain synaptic vesicles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119404

29 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24728187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence correction of random coil chemical shifts: correlation between neighbor correction factors and changes in the Ramachandran distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/24728187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24728187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein immunoreactivity in minor salivary gland biopsies of Parkinson's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24728187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of alpha-synuclein to identified fibers and synapses in the normal mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/24728187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inter-helix distances in lysophospholipid micelle-bound alpha-synuclein from pulsed ESR measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/24728187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24728187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/24728187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDU165

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24728187%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24728187%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24728187%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

ResearchGate publication ID

0 references

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