(Q34028677)

30 July 2017

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title

The fourth mammalian molybdenum enzyme mARC: current state of research (English)

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30 July 2017

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Antje Havemeyer

1

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30 July 2017

Juliane Lang

series ordinal

2

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30 July 2017

Bernd Clement

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

26 September 2011

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30 July 2017

published in

Drug Metabolism Reviews

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30 July 2017

volume

43

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30 July 2017

issue

4

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30 July 2017

page(s)

524-539

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Genomewide association study of movement-related adverse antipsychotic effects

30 July 2017

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Probing the differences between rat liver outer mitochondrial membrane cytochrome b5 and microsomal cytochromes b5

21 January 2018

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Characterization and partial purification of the rat and human enzyme systems active in the reduction of N-hydroxymelagatran and benzamidoxime

21 January 2018

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In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis

21 January 2018

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Purification and biochemical characterization of simplified eukaryotic nitrate reductase expressed in Pichia pastoris

21 January 2018

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Molybdenum hydroxylases as drug-metabolizing enzymes

21 January 2018

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The role of non-P450 enzymes in drug oxidation

21 January 2018

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Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

The hydroxylamine reductase of mitochondria

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Reduction of hydroxylamine by rat liver mitochondria

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana

21 January 2018

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Targeting of a tail-anchored protein to endoplasmic reticulum and mitochondrial outer membrane by independent but competing pathways

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Mechanism of Molybdenum Nitrogenase

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

NITRATE REDUCTASE STRUCTURE, FUNCTION AND REGULATION: Bridging the Gap between Biochemistry and Physiology

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as pro-drugs of amidines

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Reduction of amphetamine hydroxylamine and other aliphatic hydroxylamines by benzamidoxime reductase and human liver microsomes

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Diacetyldiamidoximeester of pentamidine, a prodrug for treatment of protozoal diseases: synthesis, in vitro and in vivo biotransformation.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Phase 2 metabolites of N-hydroxylated amidines (amidoximes): synthesis, in vitro formation by pig hepatocytes, and mutagenicity testing

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

N-myristoylation determines dual targeting of mammalian NADH-cytochrome b5 reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Proteomic analysis of the mouse liver mitochondrial inner membrane

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Substrate specificity of rabbit aldehyde oxidase for nitroguanidine and nitromethylene neonicotinoid insecticides

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Shortage of lipid-radical cycles in membranes as a possible prime cause of energetic failure in aging and Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Lessons learned from marketed and investigational prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Structural basis of eukaryotic nitrate reduction: crystal structures of the nitrate reductase active site

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Antibacterial action of some aromatic amines, amidines, amidoximes, guanidines and diguanidines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Physiological roles of xanthine oxidoreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Reduction of N-hydroxy-sulfonamides, including N-hydroxy-valdecoxib, by the molybdenum-containing enzyme mARC.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

The Mononuclear Molybdenum Enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Molybdenum enzymes in higher organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Rat liver peroxisomes after fibrate treatment. A survey using quantitative mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Prodrug design to improve pharmacokinetic and drug delivery properties: challenges to the discovery scientists

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

No Influence of Ethnic Origin on the Pharmacokinetics and Pharmacodynamics of Melagatran Following Oral Administration of Ximelagatran, a Novel Oral Direct Thrombin Inhibitor, to Healthy Male Volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Drug-induced liver injury in humans: the case of ximelagatran

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

In vitro assembly of Neurospora assimilatory nitrate reductase from protein subunits of a Neurospora mutant and the xanthine oxidizing or aldehyde oxidase systems of higher animals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Role of Thr(66) in porcine NADH-cytochrome b5 reductase in catalysis and control of the rate-limiting step in electron transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Drug-metabolizing ability of molybdenum hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Role for CysJ flavin reductase in molybdenum cofactor-dependent resistance of Escherichia coli to 6-N-hydroxylaminopurine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Molecular dynamics simulation studies of cytochrome b5 from outer mitochondrial and microsomal membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Enzymes involved in the bioconversion of ester-based prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Glucose regulation of CDK7, a putative thiol related gene, in experimental diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Effects of ketoconazole on the in vivo biotransformation and hepatobiliary transport of the thrombin inhibitor AZD0837 in pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Cell biology of molybdenum

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

The Oral Serine Protease Inhibitor WX-671 - First Experience in Patients with Advanced Head and Neck Carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Integrating proteomic and transcriptomic high-throughput surveys for search of new biomarkers of colon tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Possible participation of outer mitochondrial membrane cytonchrome B5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Invitro formation of assimilatory reduced nicotinamide adenine dinucleotide phosphate: nitrate reductase from a Neurospora mutant and a component of molybdenum-enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Isolation of diabetes-associated kidney genes using differential display

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

A mitochondrial protein compendium elucidates complex I disease biology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Soluble cytochrome b 5 reductase from human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Novel agents aiming at specific molecular targets increase chemosensitivity and overcome chemoresistance in hematopoietic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Molybdenum cofactors from molybdoenzymes and in vitro reconstitution of nitrogenase and nitrate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

The roles of cytochrome b5 in cytochrome P450 reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Aldehyde oxidase: an enzyme of emerging importance in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Finding the right organelle. Targeting signals in mitochondrial outer-membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Prodrugs: design and clinical applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Gene synthesis, bacterial expression, and 1H NMR spectroscopic studies of the rat outer mitochondrial membrane cytochrome b5

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

13C NMR spectroscopic and X-ray crystallographic study of the role played by mitochondrial cytochrome b5 heme propionates in the electrostatic binding to cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Molybdenum and tungsten enzymes: a crystallographic and mechanistic overview

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Dual molecules as new antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Inhibitors of Factor VIIa/tissue factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Diamidine activity against trypanosomes: the state of the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Design and synthesis of factor Xa inhibitors and their prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

New direct thrombin inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Purification and properties of rat liver microsomal stearyl coenzyme A desaturase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

A gene atlas of the mouse and human protein-encoding transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Participation of liver aldehyde oxidase in reductive metabolism of hydroxamic acids to amides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Reduced nicotinamide adenine dinucleotide-dependent reduction of tertiary amine N-oxide by liver microsomal cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Enzymatic and non-enzymatic reduction of brucine N-oxide by aldehyde oxidase and catalase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Reductive metabolism of N-nitrosodiphenylamine to the corresponding hydrazine derivative.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Evidence for involvement of liver aldehyde oxidase in reduction of nitrosamines to the corresponding hydrazine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Biological, clinical and population relevance of 95 loci for blood lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Characteristics of Nicotiana tabacum nitrate reductase protein produced in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Orally active factor Xa inhibitors: investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Involvement of molybdenum hydroxylases in reductive metabolism of nitro polycyclic aromatic hydrocarbons in mammalian skin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Genome-wide association for methamphetamine dependence: convergent results from 2 samples

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Enhancing the thermal stability of mitochondrial cytochrome b5 by introducing a structural motif characteristic of the less stable microsomal isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Pharmacokinetics and pharmacodynamics of Ro 44-3888 after single ascending oral doses of sibrafiban, an oral platelet aggregation inhibitor, in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Enzymic reduction of N-hydroxyamphetamine: the role of electron transfer system containing cytochrome b5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Thrombin inhibitors built on an azaphenylalanine scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

Molybdoproteomes and evolution of molybdenum utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.608682

10.3109/03602532.2011.608682

21 January 2018

Identifiers

DOI

1 reference

30 July 2017

1 reference