(Q34147157)

31 July 2017

title

Autophagy-regulating small molecules and their therapeutic applications (English)

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31 July 2017

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Kyung-Hwa Baek

1

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31 July 2017

Jihye Park

series ordinal

2

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31 July 2017

Injae Shin

series ordinal

3

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31 July 2017

publication date

31 January 2012

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31 July 2017

published in

Chemical Society Reviews

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31 July 2017

volume

41

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31 July 2017

issue

8

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31 July 2017

page(s)

3245-3263

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Regulation mechanisms and signaling pathways of autophagy

31 July 2017

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Fluorescent high-throughput screening of chemical inducers of neuronal differentiation in skeletal muscle cells.

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Zebrafish as a good vertebrate model for molecular imaging using fluorescent probes.

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Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.

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Autophagy as a target for anticancer therapy

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Chaperone-mediated autophagy in protein quality control

21 January 2018

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21 January 2018

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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mTOR regulation of autophagy

21 January 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

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Bidirectional transport of amino acids regulates mTOR and autophagy

21 January 2018

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Overview of macroautophagy regulation in mammalian cells

21 January 2018

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Mammalian autophagy: core molecular machinery and signaling regulation

21 January 2018

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

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21 January 2018

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Inositol trisphosphate and diacylglycerol: two interacting second messengers

21 January 2018

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The Beclin 1 network regulates autophagy and apoptosis

21 January 2018

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Inositol phosphate biochemistry

21 January 2018

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Calpain as a novel regulator of autophagosome formation

21 January 2018

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Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

21 January 2018

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A dual role for Ca(2+) in autophagy regulation

21 January 2018

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Autophagy: molecular machinery for self-eating

21 January 2018

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Network organization of the human autophagy system

21 January 2018

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The origin of the autophagosomal membrane

21 January 2018

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

21 January 2018

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A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

21 January 2018

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Mitochondria supply membranes for autophagosome biogenesis during starvation

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Autophagosome precursor maturation requires homotypic fusion

21 January 2018

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Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

21 January 2018

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Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

21 January 2018

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

21 January 2018

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Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

21 January 2018

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Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway

21 January 2018

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Formation process of autophagosome is traced with Apg8/Aut7p in yeast

21 January 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

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Role for Rab7 in maturation of late autophagic vacuoles

21 January 2018

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Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

21 January 2018

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

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Autophagy suppresses tumor progression by limiting chromosomal instability

21 January 2018

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Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer

21 January 2018

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Targeting cancer cells through autophagy for anticancer therapy

21 January 2018

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The role of autophagy in cancer development and response to therapy.

21 January 2018

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The paradox of autophagy and its implication in cancer etiology and therapy

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Autophagy gone awry in neurodegenerative diseases

21 January 2018

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

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Autophagy and its possible roles in nervous system diseases, damage and repair

21 January 2018

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Removing protein aggregates: the role of proteolysis in neurodegeneration

21 January 2018

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Potential therapeutic applications of autophagy

21 January 2018

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The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

21 January 2018

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Cell death in the pathogenesis of heart disease: mechanisms and significance

21 January 2018

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Cardiac autophagy is a maladaptive response to hemodynamic stress

21 January 2018

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21 January 2018

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Cellular autophagy: surrender, avoidance and subversion by microorganisms

21 January 2018

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Multiple regulatory and effector roles of autophagy in immunity.

21 January 2018

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Autophagy in immunity and cell-autonomous defense against intracellular microbes

21 January 2018

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Innate and adaptive immunity through autophagy

21 January 2018

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Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway

21 January 2018

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HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein

21 January 2018

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

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Autophagy-dependent viral recognition by plasmacytoid dendritic cells

21 January 2018

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Endogenous MHC class II processing of a viral nuclear antigen after autophagy.

21 January 2018

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The known unknowns of antigen processing and presentation.

21 January 2018

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Cooperation between CD4+ and CD8+ T cells: when, where, and how.

21 January 2018

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Involvement of autophagy in viral infections: antiviral function and subversion by viruses

21 January 2018

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Subversion of cellular autophagosomal machinery by RNA viruses

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21 January 2018

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21 January 2018

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Autophagy gene-dependent clearance of apoptotic cells during embryonic development

21 January 2018

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Phagocytosis of apoptotic cells and the resolution of inflammation

21 January 2018

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Inflammatory bowel disease: cause and immunobiology

21 January 2018

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Methods in mammalian autophagy research

21 January 2018

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Maturation of autophagic vacuoles in Mammalian cells

21 January 2018

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A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

21 January 2018

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LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization

21 January 2018

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Endocytosis and molecular sorting

21 January 2018

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Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates

21 January 2018

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Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

21 January 2018

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How to interpret LC3 immunoblotting

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS15328A

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS15328A

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS15328A

Monitoring autophagic degradation of p62/SQSTM1.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS15328A

Small molecule regulators of autophagy identified by an image-based high-throughput screen

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS15328A

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Using photoactivatable proteins to monitor autophagosome lifetime

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS15328A

Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2CS15328A

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

21 January 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

21 January 2018

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High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4.

21 January 2018

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Rapamycin passes the torch: a new generation of mTOR inhibitors

21 January 2018

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Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin

21 January 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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The mTOR pathway: a new target in cancer therapy.

21 January 2018

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

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Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

21 January 2018

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

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Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

21 January 2018

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 January 2018

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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Akt and autophagy cooperate to promote survival of drug-resistant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Resveratrol-induced autophagocytosis in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Lithium induces autophagy by inhibiting inositol monophosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Lithium delays progression of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Valproate decreases inositol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Control of basal autophagy by calpain1 mediated cleavage of ATG5

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Autophagy induction by trehalose counteracts cellular prion infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

A novel sphingosine kinase inhibitor induces autophagy in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Biologically active sphingolipids in cancer pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

A small molecule inhibitor of inducible heat shock protein 70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

p62, an autophagy hero or culprit?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS15328A

21 January 2018

Identifiers

DOI

10.1039/C2CS15328A

1 reference

31 July 2017

1 reference