(Q34217711)

English

Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

31 July 2017

Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism (English)

1 reference

Europe PubMed Central

31 July 2017

Alzheimer's disease

0 references

Tobias Hartmann

12

object named as

Tobias Hartmann

1 reference

Europe PubMed Central

31 July 2017

7

object named as

Lars Kaestner

1 reference

Europe PubMed Central

31 July 2017

author name string

Marcus O W Grimm

1

1 reference

Europe PubMed Central

31 July 2017

Eva G Zinser

2

1 reference

Europe PubMed Central

31 July 2017

Sven Grösgen

3

1 reference

Europe PubMed Central

31 July 2017

Benjamin Hundsdörfer

4

1 reference

Europe PubMed Central

31 July 2017

Tatjana L Rothhaar

5

1 reference

Europe PubMed Central

31 July 2017

Verena K Burg

6

1 reference

Europe PubMed Central

31 July 2017

Thomas A Bayer

8

1 reference

Europe PubMed Central

31 July 2017

Peter Lipp

9

1 reference

Europe PubMed Central

31 July 2017

Ulrike Müller

10

1 reference

Europe PubMed Central

31 July 2017

Heike S Grimm

11

1 reference

Europe PubMed Central

31 July 2017

language of work or name

0 references

publication date

28 March 2012

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

7

1 reference

Europe PubMed Central

31 July 2017

3

1 reference

Europe PubMed Central

31 July 2017

e34095

1 reference

Europe PubMed Central

31 July 2017

copyright license

Creative Commons Attribution 4.0 International

28 March 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Intracranial V. cholerae sialidase protects against excitotoxic neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

APP processing in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Pathological significance of ganglioside clusters in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Intramembrane proteolysis by gamma-secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Direct and potent regulation of gamma-secretase by its lipid microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

The metabolism and function of sphingolipids and glycosphingolipids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

GM1 ganglioside and the seeding of amyloid in Alzheimer's disease: endogenous seed for Alzheimer amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Molecular biology and genetics of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

GM1 ganglioside-mediated accumulation of amyloid beta-protein on cell membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

The cell biology of glycosphingolipids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

GM1 ganglioside regulates the proteolysis of amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Cholesterol and the biology of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Characterization of high-affinity binding between gangliosides and amyloid beta-protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Deletion of an endosomal/lysosomal targeting signal promotes the secretion of Alzheimer's disease amyloid precursor protein (APP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Interaction of triiodide anion with gangliosides in aqueous iodine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Measurement of protein using bicinchoninic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

A highly sensitive silver stain for detecting proteins and peptides in polyacrylamide gels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

5 July 2018

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Gamma-secretase: proteasome of the membrane?

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Cholesterol binding to amyloid-beta fibrils: a TEM study

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034095

21 January 2018

Gangliosides determine the amyloid pathology of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

28 October 2018

Membrane lipids of adult human brain: lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

28 October 2018

Human brain gangliosides in development, aging and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314703

28 October 2018

Inhibition of secreted phospholipases A2 by annexin V. Competition for anionic phospholipid interfaces allows an assessment of the relative interfacial affinities of secreted phospholipases A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/22470521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of toxic fibrils of Alzheimer's amyloid beta-protein-(1-40) by monosialoganglioside GM1, a neuronal membrane component

1 reference

https://pubmed.ncbi.nlm.nih.gov/22470521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GM1-gangliosidosis in a cross-bred dog confirmed by detection of GM1-ganglioside using electrospray ionisation-tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/22470521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22470521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside biosynthesis in rat liver. Characterization of three sialyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22470521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel substrate for analyzing Alzheimer's disease gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22470521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gangliosides can activate human alternative complement pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22470521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous transfer of GM3 ganglioside between vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/22470521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0034095

1 reference

Europe PubMed Central

31 July 2017

2012PLoSO...734095G

0 references

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34217711&oldid=1867979359"