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Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties

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29 January 2020

Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties (English)

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29 January 2020

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29 January 2020

Harel Weinstein

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29 January 2020

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Jufang Shan

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29 January 2020

George Khelashvili

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29 January 2020

Ernest L Mehler

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19 April 2012

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29 January 2020

PLOS Computational Biology

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29 January 2020

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29 January 2020

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29 January 2020

e1002473

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29 January 2020

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19 April 2012

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Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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Serotonin 5-HT(2A) Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases

1 reference

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The structure and function of G-protein-coupled receptors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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CHARMM: the biomolecular simulation program

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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Structural insights into G-protein-coupled receptor activation

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Crystal structure of opsin in its G-protein-interacting conformation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation

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Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

A role for a specific cholesterol interaction in stabilizing the Apo configuration of the human A(2A) adenosine receptor

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Hydrophobic coupling of lipid bilayer energetics to channel function.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Optimization of receptor-G protein coupling by bilayer lipid composition II: formation of metarhodopsin II-transducin complex

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Structure of bovine rhodopsin in a trigonal crystal form.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Absolute binding free energy calculations of sparsomycin analogs to the bacterial ribosome

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Prokink: a protocol for numerical evaluation of helix distortions by proline.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Simulaid: A simulation facilitator and analysis program

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

GROMACS 3.0: a package for molecular simulation and trajectory analysis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330085

28 October 2018

Functional Microdomains in G-protein-coupled Receptors

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

The essential dynamics of thermolysin: Confirmation of the hinge-bending motion and comparison of simulations in vacuum and water

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002473

21 January 2018

Transducin-dependent protonation of glutamic acid 134 in rhodopsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theoretical studies on the activation mechanism of the histamine H2-receptor: the proton transfer between histamine and a receptor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Flexible Docking Procedure for the Exploration of Peptide Binding Selectivity to Known Structures and Homology Models of PDZ Domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional representations of G protein-coupled receptor structures and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G Protein-Coupled Receptors Self-Assemble in Dynamics Simulations of Model Bilayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivated conformational changes in rhodopsin: a time-resolved spin label study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PCBI.1002473

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22532793%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

DBLP publication ID

journals/ploscb/ShanKMMW12

1 reference

DBLP Dataset 2021-01-02

28 January 2021

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22532793%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22532793%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

ResearchGate publication ID

0 references

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