(Q34318015)

1 August 2017

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title

Searching for the hereditary causes of renal-cell carcinoma (English)

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1 August 2017

author name string

Christian P Pavlovich

series ordinal

1

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1 August 2017

Laura S Schmidt

series ordinal

2

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1 August 2017

language of work or name

English

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publication date

1 May 2004

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1 August 2017

published in

Nature Reviews Cancer

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1 August 2017

volume

4

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1 August 2017

issue

5

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1 August 2017

page(s)

381-393

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Studying cancer families to identify kidney cancer genes

1 August 2017

cites work

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Rising incidence of renal cell cancer in the United States

31 March 2020

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The Heidelberg classification of renal cell tumours.

31 March 2020

1 reference

Identification of the von Hippel-Lindau disease tumor suppressor gene

31 March 2020

1 reference

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

31 March 2020

1 reference

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

31 March 2020

1 reference

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

31 March 2020

1 reference

HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome

31 March 2020

1 reference

Hereditary Renal-Cell Carcinoma Associated with a Chromosomal Translocation

31 March 2020

1 reference

Tissue-specific expression of a constitutional 3;6 translocation: development of multiple bilateral renal-cell carcinomas

31 March 2020

1 reference

An alternative route for multistep tumorigenesis in a novel case of hereditary renal cell cancer and a t(2;3)(q35;q21) chromosome translocation

31 March 2020

1 reference

The tuberous sclerosis complex and its highly variable manifestations

31 March 2020

1 reference

Tumour suppressors hamartin and tuberin: intracellular signalling

31 March 2020

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Recent advances in Wilms tumor genetics

31 March 2020

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von Hippel-Lindau disease

31 March 2020

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Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype

31 March 2020

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Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours

31 March 2020

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Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

31 March 2020

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Somatic point mutation of the wild-type allele detected in tumors of patients with VHL germline deletion

31 March 2020

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HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

31 March 2020

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Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

31 March 2020

1 reference

Mutations of the VHL tumour suppressor gene in renal carcinoma

31 March 2020

1 reference

Molecular basis of the VHL hereditary cancer syndrome

31 March 2020

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The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing

31 March 2020

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HIF-1: an oxygen response system with special relevance to the kidney

31 March 2020

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The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

31 March 2020

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The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

31 March 2020

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

31 March 2020

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

31 March 2020

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A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

31 March 2020

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

31 March 2020

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

31 March 2020

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

31 March 2020

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

31 March 2020

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

31 March 2020

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

31 March 2020

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

31 March 2020

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Tumour suppression by the human von Hippel-Lindau gene product

31 March 2020

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

31 March 2020

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

31 March 2020

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The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

31 March 2020

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

31 March 2020

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Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein

31 March 2020

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

31 March 2020

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

31 March 2020

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The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

31 March 2020

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VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

31 March 2020

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Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.

31 March 2020

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Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

31 March 2020

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Genotype-phenotype correlation in von Hippel-Lindau syndrome

31 March 2020

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

31 March 2020

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Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

31 March 2020

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

31 March 2020

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Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding

31 March 2020

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Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location.

31 March 2020

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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

31 March 2020

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

31 March 2020

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Original Articles: Kidney Cancer: Hereditary Papillary Renal Cell Carcinoma: Clinical Studies in 10 Families

31 March 2020

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Novel mutations of the MET proto-oncogene in papillary renal carcinomas.

31 March 2020

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Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family

31 March 2020

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Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

31 March 2020

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Pathway specificity for Met signalling

31 March 2020

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Met, metastasis, motility and more

31 March 2020

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Scatter-factor and semaphorin receptors: cell signalling for invasive growth

31 March 2020

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Activating mutations for the met tyrosine kinase receptor in human cancer

31 March 2020

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A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

31 March 2020

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

31 March 2020

1 reference

Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential

31 March 2020

1 reference

Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies

31 March 2020

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Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists

31 March 2020

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Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity

31 March 2020

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Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

31 March 2020

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Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours

31 March 2020

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Scatter factor/hepatocyte growth factor is essential for liver development

31 March 2020

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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

31 March 2020

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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

31 March 2020

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The mutationally activated Met receptor mediates motility and metastasis

31 March 2020

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Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors

31 March 2020

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Inherited susceptibility to uterine leiomyomas and renal cell cancer

31 March 2020

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Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology

31 March 2020

1 reference

Morphologic typing of papillary renal cell carcinoma: comparison of growth kinetics and patient survival in 66 cases

31 March 2020

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Chromosomal imbalances in papillary renal cell carcinoma: genetic differences between histological subtypes

31 March 2020

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Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

31 March 2020

1 reference

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

31 March 2020

1 reference

Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.

31 March 2020

1 reference

Germline mutations in fumarate hydratase (FH) do not predispose to prostate cancer

31 March 2020

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Molecular analysis and prenatal diagnosis of human fumarase deficiency

31 March 2020

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A role for mitochondrial enzymes in inherited neoplasia and beyond

31 March 2020

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Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

31 March 2020

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Familial renal oncocytoma: clinicopathological study of 5 families

31 March 2020

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Clinical and genetic studies of Birt-Hogg-Dubé syndrome.

31 March 2020

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Renal Tumors in the Birt-Hogg-Dubé Syndrome

31 March 2020

1 reference

31 March 2020

1 reference

Birt-Hogg-Dubé syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2.

31 March 2020

1 reference

Birt-Hogg-Dubé syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12-q11.2.

31 March 2020

1 reference

Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday

31 March 2020

1 reference

A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma.

31 March 2020

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A novel renal carcinoma predisposing gene of the Nihon rat maps on chromosome 10.

31 March 2020

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A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer

31 March 2020

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Hereditary multifocal renal cystadenocarcinomas and nodular dermatofibrosis in the German shepherd dog: macroscopic and histopathologic changes

31 March 2020

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Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs

31 March 2020

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A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog.

31 March 2020

1 reference

Analysis of the Birt-Hogg-Dubé (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer

31 March 2020

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Mutations of the Birt-Hogg-Dube (BHD) gene in sporadic colorectal carcinomas and colorectal carcinoma cell lines with microsatellite instability

31 March 2020

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Alterations of the Birt-Hogg-Dubé gene (BHD) in sporadic colorectal tumours

31 March 2020

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Somatic and Germ-Line Mutations of theHRPT2Gene in Sporadic Parathyroid Carcinoma

31 March 2020

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HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours

31 March 2020

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Understanding familial and non-familial renal cell cancer

31 March 2020

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The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

31 March 2020

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Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines

31 March 2020

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Replacement of Fhit in cancer cells suppresses tumorigenicity

31 March 2020

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The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8

31 March 2020

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The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway

31 March 2020

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The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation

31 March 2020

1 reference

Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21).

31 March 2020

1 reference

Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21).

31 March 2020

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The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas

31 March 2020

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Familial clear cell renal cell carcinoma (FCRC): clinical features and mutation analysis of the VHL, MET, and CUL2 candidate genes

31 March 2020

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Familial non-VHL non-papillary clear-cell renal cancer

31 March 2020

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A population-based familial aggregation analysis indicates genetic contribution in a majority of renal cell carcinomas

31 March 2020

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Imaging of hereditary renal cancer

31 March 2020

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von Hippel-Lindau disease

31 March 2020

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Percutaneous radio frequency ablation of small renal tumors: initial results

31 March 2020

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Treatment of renal cell carcinoma in von Hippel-Lindau disease: a multicenter study

31 March 2020

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Genetic and epigenetic alterations in colon cancer

31 March 2020

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

31 March 2020

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The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

31 March 2020

1 reference

Thalidomide therapy for renal cell carcinoma

31 March 2020

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A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

31 March 2020

1 reference

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

31 March 2020

1 reference

Molecular classification of cutaneous malignant melanoma by gene expression profiling

31 March 2020

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Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray.

31 March 2020

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Gene expression profiling of clear cell renal cell carcinoma: gene identification and prognostic classification

31 March 2020

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Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1364

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Dimensions Publication ID

1 August 2017

1005561663

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