(Q35143191)

6 August 2017

1 reference

title

Tumour suppressors hamartin and tuberin: intracellular signalling (English)

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6 August 2017

1

Vera P Krymskaya

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6 August 2017

1 August 2003

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6 August 2017

11

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inferred from page(s)

published in

Cellular Signalling

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6 August 2017

15

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6 August 2017

729-739

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6 August 2017

8

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

New developments in the neurobiology of the tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Molecular genetic advances in tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Multistep renal carcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model--genotype, phenotype and environment

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Neuropathology of tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberous sclerosis: between genetic and physical analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Rare diseases. 1. Lymphangioleiomyomatosis: clinical features, management and basic mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Lymphangioleiomyomatosis: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The coupling of cell growth to the cell cycle.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberous sclerosis gene products in proliferation control

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberous sclerosis complex genes: from flies to human genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Comparative analysis and genomic structure of the tuberous sclerosis 2 (TSC2) gene in human and pufferfish

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Identification and characterization of the interaction between tuberin and 14-3-3zeta

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Regulation of TSC2 by 14-3-3 binding

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Expression and differential splicing of the mouse TSC2 homolog.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

A calmodulin binding site in the tuberous sclerosis 2 gene product is essential for regulation of transcription events and is altered by mutations linked to tuberous sclerosis and lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Activation of pp60c-src depending on cell density in PC12h cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Distribution of Tsc1 protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat: detection of limited colocalization with Tsc1 and Tsc2 gene products in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Simultaneous loss of hamartin and tuberin from the cerebrum, kidney and heart with tuberous sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Hamartin expression and interaction with tuberin in tumor cell lines and primary cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Hamartin and tuberin expression in human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Expression of the tuberous sclerosis complex gene products, hamartin and tuberin, in central nervous system tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Role of S6 phosphorylation and S6 kinase in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Drosophila S6 kinase: a regulator of cell size.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Ribosomal S6 kinase signaling and the control of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

p70 S6 kinase: an enigma with variations

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tumstatin, an endothelial cell-specific inhibitor of protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Mammalian TOR: a homeostatic ATP sensor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The target of rapamycin (TOR) proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The TSC1 gene product, hamartin, negatively regulates cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Cells derived from tuberous sclerosis show a prolonged S phase of the cell cycle and increased apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

A novel missense mutation in the GTPase activating protein homology region of TSC2 in two large families with tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Identification of cDNAs induced by the tumor suppressor Tsc2 gene using a conditional expression system in Tsc2 mutant (Eker) rat renal carcinoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease--a contiguous gene syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

The polycystic kidney disease 1 gene product modulates Wnt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Chromosome 16 Loss of Heterozygosity in Tuberous Sclerosis and Sporadic Lymphangiomyomatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

ERM proteins and merlin: integrators at the cell cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900040-8

7 January 2021

10.1016/S0898-6568(03)00040-8

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12781866