(Q34343590)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Drosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

0 references

1 reference

GOA release 2020-03-11

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

author name string

Zachary Sebo

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Laramie Pence

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Leonard L Dobens

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

language of work or name

English

0 references

publication date

15 October 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

page(s)

e109530

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

21 February 2020

copyright license

start time

15 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4198113/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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High sugar-induced insulin resistance in Drosophila relies on the lipocalin Neural Lazarillo

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Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

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Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

6 July 2018

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Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response.

6 July 2018

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A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

6 July 2018

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6 July 2018

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Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

6 July 2018

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Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation

6 July 2018

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Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms

6 July 2018

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Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance

6 July 2018

1 reference

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Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice

6 July 2018

1 reference

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The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

6 July 2018

1 reference

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Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans.

6 July 2018

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Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia

6 July 2018

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An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.

6 July 2018

1 reference

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Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia

6 July 2018

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Molecular mechanisms of metabolic regulation by insulin in Drosophila

6 July 2018

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Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance

6 July 2018

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Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis

6 July 2018

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Regulation of fat cell mass by insulin in Drosophila melanogaster

6 July 2018

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Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta

6 July 2018

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The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes

6 July 2018

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PI3K activates negative and positive signals to regulate TRB3 expression in hepatic cells

6 July 2018

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LDL uptake by monocytes in response to inflammation is MAPK dependent but independent of tribbles protein expression

6 July 2018

1 reference

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TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity

6 July 2018

1 reference

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Insulin-like signaling, nutrient homeostasis, and life span

6 July 2018

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Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency

6 July 2018

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TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta

6 July 2018

1 reference

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How flies get their size: genetics meets physiology

6 July 2018

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Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

6 July 2018

1 reference

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Tribbles: a family of kinase-like proteins with potent signalling regulatory function.

6 July 2018

1 reference

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Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

6 July 2018

1 reference

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Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity

6 July 2018

1 reference

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Glucose, dexamethasone, and the unfolded protein response regulate TRB3 mRNA expression in 3T3-L1 adipocytes and L6 myotubes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

Transcriptional feedback control of insulin receptor by dFOXO/FOXO1.

6 July 2018

1 reference

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The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

6 July 2018

1 reference

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Lack of evidence for a role of TRB3/NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes

6 July 2018

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6 July 2018

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Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster

6 July 2018

1 reference

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Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster

6 July 2018

1 reference

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The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

6 July 2018

1 reference

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Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

6 July 2018

1 reference

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

6 July 2018

1 reference

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

Insulin signaling pathways in time and space.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

Genetic control of size in Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

Mechanisms and consequences of activation of protein kinase B/Akt

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

6 July 2018

1 reference

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Purification and characterization of phosphoinositide 3-kinase from rat liver

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation

6 July 2018

1 reference

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A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila

21 January 2018

1 reference

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Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

21 January 2018

1 reference

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Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

21 January 2018

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Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

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Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

21 January 2018

1 reference

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PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Overexpression of TRB3 gene in adipose tissue of rats with high fructose-induced metabolic syndrome

21 January 2018

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Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Polymorphisms associated with cholesterol and risk of cardiovascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Antagonistic actions of ecdysone and insulins determine final size in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

The kinase domain of Drosophila Tribbles is required for turnover of fly C/EBP during cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Altering Drosophila S6 kinase activity is consistent with a role for S6 kinase in growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

TRB3, upregulated by ox-LDL, mediates human monocyte-derived macrophage apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

Percentage of smudge cells determined on routine blood smears is a novel prognostic factor in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

The Drosophila insulin receptor is required for normal growth

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198113

Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population

27 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109530

TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25329475

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TRIB3 R84 Variant Is Associated With Impaired Insulin-Mediated Nitric Oxide Production in Human Endothelial Cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25329475

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0109530

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

25329475

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329475%20AND%20SRC:MED&resulttype=core&format=json