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TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery.
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Europe PubMed Central
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4207558
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22 February 2020
title
TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery
(English)
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Europe PubMed Central
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4207558
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22 February 2020
main subject
CRISPR
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A A Nemudryi
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1
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22 February 2020
K R Valetdinova
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2
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22 February 2020
S P Medvedev
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22 February 2020
S M Zakian
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4
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publication date
1 July 2014
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22 February 2020
published in
Acta Naturae
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4207558
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22 February 2020
volume
6
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22 February 2020
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3
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22 February 2020
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19-40
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22 February 2020
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Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
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Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients.
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Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs
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Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes
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Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos
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6 July 2018
Computational predictions provide insights into the biology of TAL effector target sites
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Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
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Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
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6 July 2018
Mammalian base excision repair: the forgotten archangel
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6 July 2018
Robust, synergistic regulation of human gene expression using TALE activators
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
RNA-programmed genome editing in human cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Efficient genome editing in zebrafish using a CRISPR-Cas system
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Mojo Hand, a TALEN design tool for genome editing applications.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Rapid and efficient gene modification in rice and Brachypodium using TALENs
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
RNA-guided human genome engineering via Cas9
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Multiplex genome engineering using CRISPR/Cas systems
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
A TALEN genome-editing system for generating human stem cell-based disease models
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Transcription activator-like effector nucleases enable efficient plant genome engineering.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Targeting G with TAL effectors: a comparison of activities of TALENs constructed with NN and NK repeat variable di-residues
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Highly efficient and specific genome editing in silkworm using custom TALENs
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Efficient TALEN-mediated gene knockout in livestock
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Engineering designer transcription activator-like effector nucleases (TALENs) by REAL or REAL-Fast assembly
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Chimeric TALE recombinases with programmable DNA sequence specificity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
In vivo genome editing using a high-efficiency TALEN system
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Characterization of CRISPR RNA processing in Clostridium thermocellum and Methanococcus maripaludis
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Targeted DNA mutagenesis for the cure of chronic viral infections
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
CRISPR interference directs strand specific spacer acquisition
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Chimeric piggyBac transposases for genomic targeting in human cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
FLASH assembly of TALENs for high-throughput genome editing
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
TALE nucleases: tailored genome engineering made easy
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
A transcription activator-like effector toolbox for genome engineering
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Surrogate reporters for enrichment of cells with nuclease-induced mutations
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
TAL effectors: customizable proteins for DNA targeting
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Genetic engineering of human pluripotent cells using TALE nucleases
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Targeted genome editing across species using ZFNs and TALENs
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Recognition and maturation of effector RNAs in a CRISPR interference pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Evolution and classification of the CRISPR-Cas systems
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
A modular cloning system for standardized assembly of multigene constructs
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
A TALE nuclease architecture for efficient genome editing
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Targeted integration in rat and mouse embryos with zinc-finger nucleases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Harnessing transposons for cancer gene discovery
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Genome editing with engineered zinc finger nucleases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
A rapid and general assay for monitoring endogenous gene modification
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Targeting DNA double-strand breaks with TAL effector nucleases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Targeted genome modification in mice using zinc-finger nucleases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Self versus non-self discrimination during CRISPR RNA-directed immunity.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Breaking the code of DNA binding specificity of TAL-type III effectors
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
A simple cipher governs DNA recognition by TAL effectors
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
CRISPI: a CRISPR interactive database
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Knockout rats via embryo microinjection of zinc-finger nucleases
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
High-throughput insertional mutagenesis screens in mice to identify oncogenic networks
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
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6 July 2018
Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
High-frequency modification of plant genes using engineered zinc-finger nucleases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Short motif sequences determine the targets of the prokaryotic CRISPR defence system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Small RNAs as guardians of the genome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
CRISPR families of the crenarchaeal genus Sulfolobus: bidirectional transcription and dynamic properties
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
A three-dimensional view of the molecular machinery of RNA interference
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Gene-for-gene-mediated recognition of nuclear-targeted AvrBs3-like bacterial effector proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Emerging technologies for gene manipulation in Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Mechanisms of gene silencing by double-stranded RNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Agroinfiltration is a versatile tool that facilitates comparative analyses of Avr9/Cf-9-induced and Avr4/Cf-4-induced necrosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
6 July 2018
Designable DNA-binding domains enable construction of logic circuits in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Generating rats with conditional alleles using CRISPR/Cas9.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Targeted mutagenesis in rice using CRISPR-Cas system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Efficient genome editing in plants using a CRISPR/Cas system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
RNA-guided genome editing in plants using a CRISPR-Cas system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Synergistic and tunable human gene activation by combinations of synthetic transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
An integrated chip for the high-throughput synthesis of transcription activator-like effectors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
High-efficiency TALEN-based gene editing produces disease-resistant rice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Site-specific integration and tailoring of cassette design for sustainable gene transfer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Heritable gene targeting in zebrafish using customized TALENs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Targeted gene disruption in somatic zebrafish cells using engineered TALENs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Knockout rats generated by embryo microinjection of TALENs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Methods for homologous recombination in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Gene targeting in Drosophila and Caenorhabditis elegans with zinc-finger nucleases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207558
retrieved
27 October 2018
Gene targeting by homologous recombination in Drosophila
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25349712
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Method of the Year 2011
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25349712
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
TAL effector RVD specificities and efficiencies
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25349712
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Knockout mice created by TALEN-mediated gene targeting
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25349712
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Live visualization of chromatin dynamics with fluorescent TALEs
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25349712
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CasOT: a genome-wide Cas9/gRNA off-target searching tool
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25349712
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
PMC publication ID
4207558
1 reference
stated in
Europe PubMed Central
PMC publication ID
4207558
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25349712%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PubMed publication ID
25349712
1 reference
stated in
Europe PubMed Central
PMC publication ID
4207558
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25349712%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
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