(Q34481815)

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The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

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1 March 2020

The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ (English)

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1 March 2020

Alzheimer's disease

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Maciej Lalowski

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1 March 2020

Martin Ingelsson

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Martin Ingelsson

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1 March 2020

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Lars Lannfelt

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1 March 2020

author name string

Hannu Kalimo

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1 March 2020

Nenad Bogdanovic

3

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1 March 2020

Ola Philipson

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1 March 2020

Thomas D Bird

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1 March 2020

David Nochlin

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1 March 2020

Gerard D Schellenberg

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1 March 2020

Rosemarie Brundin

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1 March 2020

Tommie Olofsson

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1 March 2020

Rabah Soliymani

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1 March 2020

Thomas A Bayer

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1 March 2020

Hans Basun

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1 March 2020

publication date

10 September 2013

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1 March 2020

Acta Neuropathologica Communications

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1 March 2020

1

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60

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1 March 2020

https://scigraph.springernature.com/pub.10.1186/2051-5960-1-60

0 references

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

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6 July 2018

Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM

1 reference

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6 July 2018

Intraneuronal Aβ accumulation and neurodegeneration: lessons from transgenic models.

1 reference

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6 July 2018

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

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6 July 2018

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

1 reference

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6 July 2018

Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits

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6 July 2018

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

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6 July 2018

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

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6 July 2018

Classification and basic pathology of Alzheimer disease

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6 July 2018

Variations in the neuropathology of familial Alzheimer's disease

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6 July 2018

Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

6 July 2018

Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

6 July 2018

Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease

1 reference

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6 July 2018

Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium

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6 July 2018

Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

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6 July 2018

Sensitive ELISA detection of amyloid-beta protofibrils in biological samples

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

6 July 2018

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

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6 July 2018

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

1 reference

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6 July 2018

A specific amyloid-beta protein assembly in the brain impairs memory

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6 July 2018

Hereditary cerebral hemorrhage with amyloidosis-Dutch type

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

6 July 2018

What is the function of the claustrum?

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6 July 2018

Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

6 July 2018

Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay

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6 July 2018

Molecular mechanisms initiating amyloid beta-fibril formation in Alzheimer's disease.

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6 July 2018

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

6 July 2018

A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

1 reference

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6 July 2018

Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1.

1 reference

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6 July 2018

Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

1 reference

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6 July 2018

Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

6 July 2018

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

6 July 2018

The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease

1 reference

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6 July 2018

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

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6 July 2018

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

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6 July 2018

Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region

1 reference

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6 July 2018

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

1 reference

https://api.crossref.org/works/10.1186%2F2051-5960-1-60

21 January 2018

Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP.

1 reference

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21 January 2018

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

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21 January 2018

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers.

1 reference

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21 January 2018

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

1 reference

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21 January 2018

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

1 reference

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21 January 2018

PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease

1 reference

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21 January 2018

APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38.

1 reference

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21 January 2018

Presenilin-1 mutations in Alzheimer's disease.

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21 January 2018

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

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21 January 2018

Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers

1 reference

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21 January 2018

Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

1 reference

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21 January 2018

Abeta protofibrils possess a stable core structure resistant to hydrogen exchange

1 reference

https://api.crossref.org/works/10.1186%2F2051-5960-1-60

21 January 2018

The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

27 October 2018

Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

27 October 2018

Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

27 October 2018

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226306

27 October 2018

Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease.

1 reference

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27 October 2018

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10.1186/2051-5960-1-60

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1 March 2020

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1 March 2020

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1 March 2020

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