(Q34483923)

2 August 2017

1 reference

title

Assignment of protein function in the postgenomic era. (English)

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2 August 2017

2

Benjamin F Cravatt

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2 August 2017

Alan Saghatelian

1

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PubMed ID

16408016

2 August 2017

language of work or name

1 reference

1 August 2005

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2 August 2017

Nature Chemical Biology

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2 August 2017

1

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2 August 2017

3

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2 August 2017

130-142

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https://scigraph.springernature.com/pub.10.1038/nchembio0805-130

2 August 2017

0 references

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Activity-based protein profiling: the serine hydrolases

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Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

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Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo

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Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

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A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

21 January 2018

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Discovering disease-associated enzymes by proteome reactivity profiling

21 January 2018

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Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

21 January 2018

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Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

21 January 2018

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Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

21 January 2018

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Activity-based probes that target diverse cysteine protease families

21 January 2018

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Activity-based probes for the proteomic profiling of metalloproteases

21 January 2018

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Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases.

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome.

21 January 2018

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Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy

21 January 2018

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Activity-based probes for protein tyrosine phosphatases

21 January 2018

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Design and synthesis of AX7574: a microcystin-derived, fluorescent probe for serine/threonine phosphatases

21 January 2018

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Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

21 January 2018

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A strategy for functional proteomic analysis of glycosidase activity from cell lysates.

21 January 2018

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Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

21 January 2018

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Profiling the specific reactivity of the proteome with non-directed activity-based probes

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A chemical approach for identifying O-GlcNAc-modified proteins in cells

21 January 2018

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A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation

21 January 2018

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A tagging-via-substrate technology for detection and proteomics of farnesylated proteins

21 January 2018

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Enzymatic incorporation of orthogonally reactive prenylazide groups into peptides using geranylazide diphosphate via protein farnesyltransferase: implications for selective protein labeling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

A chemoenzymatic approach toward the rapid and sensitive detection of O-GlcNAc posttranslational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

The protein kinase complement of the human genome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

A chemical switch for inhibitor-sensitive alleles of any protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Targets of the cyclin-dependent kinase Cdk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Allele-specific inhibitors of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Semisynthesis of proteins by expressed protein ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Chemical Dissection of the Effects of Tyrosine Phosphorylation of SHP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Catalytic subunit of protein kinase A caged at the activating phosphothreonine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Fluorescent caged phosphoserine peptides as probes to investigate phosphorylation-dependent protein associations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

21 January 2018

Caged phosphoproteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Photocontrol of Smad2, a multiphosphorylated cell-signaling protein, through caging of activating phosphoserines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Cofilin promotes actin polymerization and defines the direction of cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

An expanded eukaryotic genetic code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Protein semi-synthesis in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Molecular phenotyping of the pal1 and pal2 mutants of Arabidopsis thaliana reveals far-reaching consequences on phenylpropanoid, amino acid, and carbohydrate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Assignment of endogenous substrates to enzymes by global metabolite profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Definitions of enzyme function for the structural genomics era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Shotgun: getting more from sequence similarity searches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Divergence of function in the thioredoxin fold suprafamily: evidence for evolution of peroxiredoxins from a thioredoxin-like ancestor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Active site-directed protein regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Chemical proteomics applied to target identification and drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Microarray platform for profiling enzyme activities in complex proteomes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Kinomics: methods for deciphering the kinome

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Toward a model for the interaction between elongation factor Tu and the ribosome.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Selective inhibition of engineered receptors via proximity-accelerated alkylation

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

General method for the synthesis of caged phosphopeptides: tools for the exploration of signal transduction pathways

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Expanding the genetic code of Escherichia coli

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease

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https://api.crossref.org/works/10.1038%2FNCHEMBIO0805-130

7 January 2021

Elucidation of gene-to-gene and metabolite-to-gene networks in arabidopsis by integration of metabolomics and transcriptomics

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7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO0805-130

1 reference

PubMed ID

16408016

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

16408016