(Q34610817)

3 August 2017

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title

The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications (English)

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3 August 2017

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Ulrich Klotz

1

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3 August 2017

publication date

1 January 2007

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Clinical Pharmacokinetics

3 August 2017

published in

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3 August 2017

volume

46

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3 August 2017

issue

4

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3 August 2017

page(s)

271-279

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Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms

3 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200746040-00001

Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite

21 January 2018

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12 December 2020

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

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12 December 2020

Influence of the CYP2C9 AND CYP2C19 polymorphisms on phenytoin hydroxylation in healthy individuals from south India.

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12 December 2020

Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience

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12 December 2020

Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?

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12 December 2020

High-performance liquid chromatographic determination of aminosalicylate, sulfapyridine and their metabolites. Its application for pharmacokinetic studies with salicylazosulfapyridine in man

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12 December 2020

Clinically relevant drug interactions with antiepileptic drugs

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12 December 2020

Clinical consequences of cytochrome P450 2C9 polymorphisms

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12 December 2020

Personalized drug therapy; the genome, the chip and the physician

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12 December 2020

Pharmacogenetic testing for drug metabolizing enzymes: is it happening in practice?

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12 December 2020

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

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12 December 2020

Therapeutic drug monitoring of old and newer anti-epileptic drugs.

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12 December 2020

Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy

1 reference

12 December 2020

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

1 reference

12 December 2020

CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia

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12 December 2020

Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin

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12 December 2020

HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy

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12 December 2020

Clinical significance of the cytochrome P450 2C19 genetic polymorphism

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12 December 2020

Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests

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12 December 2020

Update on pharmacogenetics in epilepsy: a brief review.

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12 December 2020

Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same?

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12 December 2020

Challenges and opportunities in the application of pharmacogenetics to antiepileptic drug therapy

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12 December 2020

Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid

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12 December 2020

Modern antiepileptic drugs: guidelines and beyond

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12 December 2020

So many studies, too few subjects: establishing functional relevance of genetic polymorphisms on pharmacokinetics

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12 December 2020

Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid

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12 December 2020

Update on the acute management of status epilepticus in children.

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12 December 2020

Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients.

1 reference

12 December 2020

Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin

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12 December 2020

The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics

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12 December 2020

Pharmacogenetics and pharmacogenomics: are they still promising?

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12 December 2020

New antiepileptic drugs that are second generation to existing antiepileptic drugs

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12 December 2020

Genetic polymorphism of cytochrome P450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions

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12 December 2020

Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

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12 December 2020

Can pharmacokinetic variability be controlled for the patient's benefit? The place of TDM for new AEDs

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12 December 2020

Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

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12 December 2020

Pharmacogenetics and pharmacogenomics: origin, status, and the hope for personalized medicine

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12 December 2020

The pharmacokinetics and interactions of new antiepileptic drugs: an overview

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12 December 2020

Therapeutic drug monitoring of the newer antiepileptic drugs

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12 December 2020

Single-dose kinetics and metabolism of carbamazepine-10,11-epoxide

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12 December 2020

Drug metabolism and drug interactions in the elderly

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12 December 2020

Polymorphic hydroxylation of Debrisoquine in man.

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12 December 2020

EFNS guideline on the management of status epilepticus.

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12 December 2020

Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world

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12 December 2020

Factors influencing the metabolism of diazepam

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12 December 2020

Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms

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12 December 2020

Drug metabolism and variability among patients in drug response

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12 December 2020

CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics

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12 December 2020

The potential of pharmacogenetics in the treatment of epilepsy

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12 December 2020

Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.

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12 December 2020

CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects

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12 December 2020

Pharmacogenetics-based therapeutic recommendations — ready for clinical practice?

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12 December 2020

Measuring the value of pharmacogenomics

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12 December 2020

Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy

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12 December 2020

Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats

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12 December 2020

Mephenytoin hydroxylation deficiency: kinetics after repeated doses

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12 December 2020

Selection criteria for the clinical use of the newer antiepileptic drugs.

1 reference

12 December 2020

Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes

1 reference

12 December 2020

Valproic acid and the liver.

1 reference

12 December 2020

10.2165/00003088-200746040-00001

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

1003349803

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