(Q34674177)

3 August 2017

title

Pathogenesis of Parkinson disease--the gut-brain axis and environmental factors (English)

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3 August 2017

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2

Heinz Reichmann

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3 August 2017

Lisa Klingelhoefer

1

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3 August 2017

language of work or name

English

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publication date

27 October 2015

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3 August 2017

published in

Nature Reviews Neurology

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3 August 2017

volume

11

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3 August 2017

issue

11

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3 August 2017

page(s)

625-636

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2015.197

3 August 2017

exact match

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Colonic transit time and rectoanal videomanometry in Parkinson's disease

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Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

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Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders

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Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

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21 January 2018

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The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease.

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution--a pilot study

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Enteric glia and neuroprotection: basic and clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Colonic inflammation in Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Enteric GFAP expression and phosphorylation in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

The role of glial cells and apoptosis of enteric neurones in the neuropathology of intractable slow transit constipation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Enteric glial cells: new players in Parkinson's disease?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Alpha-synuclein pathology is highly dependent on the case selection.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Occupational and environmental risk factors for Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Environmental risk factors and Parkinson's disease: a metaanalysis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Well-water consumption and Parkinson's disease in rural California

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case-control study in Germany.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Parkinson's disease and brain levels of organochlorine pesticides.

21 January 2018

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Parkinson's disease and exposure to agricultural work and pesticide chemicals

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Progression after chronic manganese exposure

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Rotenone, paraquat, and Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Cigarette smoking and Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Prospective study of caffeine consumption and risk of Parkinson's disease in men and women.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Gut feelings about smoking and coffee in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Gut microbiota are related to Parkinson's disease and clinical phenotype

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Voices from within: gut microbes and the CNS.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

21 January 2018

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Parkinson's disease subtypes: lost in translation?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Clinical subtypes of Parkinson's disease

21 January 2018

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Caudo-rostral brain spreading of α-synuclein through vagal connections

21 January 2018

1 reference

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Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents

21 January 2018

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Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Vagotomy and subsequent risk of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Small intestinal bacterial overgrowth in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Helicobacter pylori infection is associated with worse severity of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Helicobacter pylori infection and motor fluctuations in patients with Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Pharmacokinetics of levodopa in patients with Parkinson disease and motor fluctuations depending on the presence of Helicobacter pylori infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Dietary factors in Parkinson's disease: the role of food groups and specific foods

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Environmental, life-style, and physical precursors of clinical Parkinson?s disease: recent findings from the Honolulu-Asia Aging Study

21 January 2018

1 reference

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Dietary intakes of fat and risk of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Dietary fats, cholesterol and iron as risk factors for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Dietary fat intake, pesticide use, and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Toxin-induced models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Animal models of the non-motor features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Effects of oral administration of rotenone on gastrointestinal functions in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Biophysical Characterization of α-Synuclein and Rotenone Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Research in motion: the enigma of Parkinson's disease pathology spread

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Disease modification in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Oxidative stress in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Inflammation and neurodegeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Alpha-synuclein transmission and mitochondrial toxicity in primary human foetal enteric neurons in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

The rotenone model of Parkinson's disease: genes, environment and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Oxidized quercetin inhibits α-synuclein fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Histone deacetylase 6 regulates cytotoxic α-synuclein accumulation through induction of the heat shock response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.197

Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential

21 January 2018

1 reference

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Polyphenols and mitochondria: an update on their increasingly emerging ROS-scavenging independent actions

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Questionnaire-based assessment of pelvic organ dysfunction in Parkinson's disease

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Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: Templation and inhibition involve oligomers with different structure

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The role of small intestinal bacterial overgrowth in Parkinson's disease

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Gastrointestinal dysfunction in Parkinson's Disease

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Gastrointestinal manifestations in Parkinson's disease: prevalence and occurrence before motor symptoms

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Gastrointestinal dysfunction in Parkinson's disease

31 March 2020

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Gastrointestinal symptoms in Parkinson's disease

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Excess burden of constipation in Parkinson's disease: a pilot study

31 March 2020

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Anorectal manometry in the assessment of anorectal function in Parkinson's disease: a comparison with chronic idiopathic constipation

31 March 2020

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Where does parkinson disease pathology begin in the brain?

31 March 2020

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Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system

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Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons

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Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses

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Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells

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Pathological lesions in colonic biopsies during Parkinson's disease

31 March 2020

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Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation

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31 March 2020

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Linking Smoking, Coffee, Urate, and Parkinson's Disease - A Role for Gut Microbiota?

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Helicobacter pylori eradication for Parkinson's disease

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Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study

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Lewy body pathology in long-term fetal nigral transplants: is Parkinson's disease transmitted from one neural system to another?

31 March 2020

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Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

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The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?

31 March 2020

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Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease.

31 March 2020

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FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells.

31 March 2020

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Gastrointestinal symptoms in Parkinson disease: 18-month follow-up study

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Colonic transit time in nonidiopathic Parkinson's syndrome

31 March 2020

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Toxin-induced and genetic animal models of Parkinson's disease

31 March 2020

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12 December 2020

Defecatory disorders in de novo Parkinsonians--colonic transit and electromyogram of the external anal sphincter

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Neuroanatomy and pathology of sporadic Parkinson's disease.

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Characterization of swallowing and defecation in Parkinson's disease.

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Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease

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Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD.

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The dorsal motor nucleus of the vagus nerve of the hamster: ultrastructure of vagal neurons and their responses to vagotomy

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Autonomic nervous system disturbances in Parkinson's disease

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Bladder, bowel, and sexual dysfunction in Parkinson's disease

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Identifiers

DOI

1 reference

Dimensions Publication ID

3 August 2017

1045275780

0 references

1 reference