(Q34929949)

5 August 2017

1 reference

title

Integration of the TGF-beta pathway into the cellular signalling network (English)

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5 August 2017

2

Petra Knaus

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author name string

Marion Lutz

series ordinal

1

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5 August 2017

Petra Knaus

series ordinal

2

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5 August 2017

publication date

1 December 2002

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5 August 2017

number of pages

12

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inferred from page(s)

published in

Cellular Signalling

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5 August 2017

volume

14

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5 August 2017

issue

12

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5 August 2017

page(s)

977-988

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TGF-beta signal transduction

5 August 2017

cites work

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Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

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TGF beta signals through a heteromeric protein kinase receptor complex

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7 January 2021

Mechanism of activation of the TGF-beta receptor

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7 January 2021

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

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7 January 2021

A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity

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Determinants of specificity in TGF-beta signal transduction.

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7 January 2021

The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation

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7 January 2021

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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7 January 2021

TGF-beta signalling through the Smad pathway

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Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

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7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

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7 January 2021

TGF-beta latency: biological significance and mechanisms of activation

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7 January 2021

Regulation of transforming growth factor-beta signaling

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7 January 2021

Latency, activation, and binding proteins of TGF-beta

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7 January 2021

Divergence and convergence of TGF-beta/BMP signaling

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7 January 2021

Expression cloning and characterization of the TGF-beta type III receptor

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7 January 2021

The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands

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7 January 2021

Betaglycan presents ligand to the TGF beta signaling receptor.

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7 January 2021

Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor beta 2

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7 January 2021

Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart

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7 January 2021

Alternative splicing within the TGF-beta type I receptor gene (ALK-5) generates two major functional isoforms in vascular smooth muscle cells

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7 January 2021

Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor

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7 January 2021

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

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7 January 2021

Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1

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7 January 2021

Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation

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7 January 2021

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

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7 January 2021

A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system

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7 January 2021

The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line

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7 January 2021

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

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7 January 2021

Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors

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7 January 2021

Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain

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7 January 2021

A human transforming growth factor-beta type II receptor that contains an insertion in the extracellular domain

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7 January 2021

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system

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7 January 2021

Betaglycan has multiple binding sites for transforming growth factor-beta 1.

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7 January 2021

Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin A

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7 January 2021

Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta

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7 January 2021

Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling

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7 January 2021

Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation. Glycosaminoglycan modifications alter betaglycan function

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7 January 2021

TGF-beta receptor expression on human keratinocytes: a 150 kDa GPI-anchored TGF-beta1 binding protein forms a heteromeric complex with type I and type II receptors

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7 January 2021

Lipid rafts and signal transduction

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7 January 2021

Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

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7 January 2021

The types II and III transforming growth factor-beta receptors form homo-oligomers

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7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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7 January 2021

Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane

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7 January 2021

Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

1 reference

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7 January 2021

Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/Type II receptor complex in live cells.

1 reference

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7 January 2021

Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors

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7 January 2021

Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes.

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7 January 2021

Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues

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7 January 2021

Lipid rafts and little caves. Compartmentalized signalling in membrane microdomains

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7 January 2021

Functional rafts in cell membranes

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7 January 2021

Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor

1 reference

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7 January 2021

Transforming growth factor (TGF)-beta 1 internalization: modulation by ligand interaction with TGF-beta receptors types I and II and a mechanism that is distinct from clathrin-mediated endocytosis

1 reference

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7 January 2021

Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells

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7 January 2021

Mechanisms of transforming growth factor-beta receptor endocytosis and intracellular sorting differ between fibroblasts and epithelial cells

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7 January 2021

Differential requirement for type I and type II transforming growth factor beta receptor kinase activity in ligand-mediated receptor endocytosis

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7 January 2021

Down-regulation of transforming growth factor-beta receptors: cooperativity between the types I, II, and III receptors and modulation at the cell surface

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Distinct endocytic responses of heteromeric and homomeric transforming growth factor beta receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12

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7 January 2021

Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptorin Vivo

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7 January 2021

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

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7 January 2021

Mechanism of TGFβ receptor inhibition by FKBP12

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7 January 2021

The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

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7 January 2021

FKBP12 is a negative regulator of transforming growth factor-beta receptor internalization

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7 January 2021

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

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7 January 2021

A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor

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7 January 2021

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.

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7 January 2021

Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-beta/Smad3-mediated signaling.

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7 January 2021

Structural basis of Smad2 recognition by the Smad anchor for receptor activation

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7 January 2021

Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone

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7 January 2021

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7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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7 January 2021

Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling

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7 January 2021

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

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7 January 2021

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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7 January 2021

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

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7 January 2021

Regulation of Smad7 promoter by direct association with Smad3 and Smad4.

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7 January 2021

The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling

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7 January 2021

STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

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7 January 2021

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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7 January 2021

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

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7 January 2021

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

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7 January 2021

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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7 January 2021

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

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7 January 2021

Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1

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7 January 2021

Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7

1 reference

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7 January 2021

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

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7 January 2021

X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

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7 January 2021

The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response

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7 January 2021

Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors

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7 January 2021

Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

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7 January 2021

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Mads and Smads in TGF beta signalling

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7 January 2021

Signaling of transforming growth factor-beta family members through Smad proteins

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7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Smads bind directly to the Jun family of AP-1 transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Region between alpha-helices 3 and 4 of the mad homology 2 domain of Smad4: functional roles in oligomer formation and transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Structural basis of Smad1 activation by receptor kinase phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Sedimentation studies reveal a direct role of phosphorylation in Smad3:Smad4 homo- and hetero-trimerization

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Formation of a stable heterodimer between Smad2 and Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Crystal Structure of a Phosphorylated Smad2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Phosphoserine-dependent regulation of protein-protein interactions in the Smad pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Smads as transcriptional co-modulators

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

How cells read TGF-beta signals

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Microtubule binding to Smads may regulate TGF beta activity

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Filamin associates with Smads and regulates transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Regulation of Smad signaling by protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900058-X

7 January 2021

10.1016/S0898-6568(02)00058-X

Identifiers

DOI

1 reference

5 August 2017

1 reference