(Q34939590)

5 August 2017

title

Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1) (English)

1 reference

single-nucleotide polymorphism

5 August 2017

0 references

1 reference

Mark Connor

2

0 references

author name string

Alisa Knapman

series ordinal

1

1 reference

5 August 2017

language of work or name

English

0 references

publication date

1 July 2014

1 reference

British Journal of Pharmacology

5 August 2017

published in

1 reference

5 August 2017

volume

172

1 reference

5 August 2017

issue

2

1 reference

5 August 2017

page(s)

349-363

1 reference

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor

5 August 2017

cites work

1 reference

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8 July 2018

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Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells

8 July 2018

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Endomorphin-2: a biased agonist at the μ-opioid receptor.

8 July 2018

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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

8 July 2018

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Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G

8 July 2018

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New vistas in opioid control of pain

8 July 2018

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Elucidation of mu-Opioid Gene Structure: How Genetics Can Help Predict Responses to Opioids

8 July 2018

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Structural basis for μ-opioid receptor binding and activation

8 July 2018

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Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A μ-opioid receptor knock-in mice.

8 July 2018

1 reference

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Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Successful prediction of the intra- and extracellular loops of four G-protein-coupled receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies

8 July 2018

1 reference

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Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

8 July 2018

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A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African American women

8 July 2018

1 reference

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The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

A genetic determinant of the striatal dopamine response to alcohol in men

8 July 2018

1 reference

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

8 July 2018

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Long-term opioid management for chronic noncancer pain

8 July 2018

1 reference

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OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications

8 July 2018

1 reference

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Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Functional characterization of human variants of the mu-opioid receptor gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Variable response to opioid treatment: any genetic predictors within sight?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

G protein-coupled receptors disrupted in human genetic disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Role of receptor internalization in opioid tolerance and dependence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Agonist-selective mechanisms of GPCR desensitization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists

8 July 2018

1 reference

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Ligand-specific receptor states: implications for opiate receptor signalling and regulation

8 July 2018

1 reference

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Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Differential activation of G-proteins by mu-opioid receptor agonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

75 years of opioid research: the exciting but vain quest for the Holy Grail

8 July 2018

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Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids

8 July 2018

1 reference

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Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

8 July 2018

1 reference

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How individual sensitivity to opiates can be predicted by gene analyses

8 July 2018

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STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor

8 July 2018

1 reference

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Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments

8 July 2018

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Are mu-opioid receptor polymorphisms important for clinical opioid therapy?

8 July 2018

1 reference

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Mu-opioid receptor desensitization: is morphine different?

8 July 2018

1 reference

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Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease

8 July 2018

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Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor

8 July 2018

1 reference

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Efficacy at G-protein-coupled receptors

8 July 2018

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Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization.

8 July 2018

1 reference

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Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.

8 July 2018

1 reference

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Opioid receptor and peptide gene polymorphisms: potential implications for addictions

8 July 2018

1 reference

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A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

8 July 2018

1 reference

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Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes

8 July 2018

1 reference

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Molecular mechanisms and regulation of opioid receptor signaling

8 July 2018

1 reference

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Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

8 July 2018

1 reference

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Calmodulin binding to G protein-coupling domain of opioid receptors

8 July 2018

1 reference

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Opioid receptor signalling mechanisms.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

A conserved arginine in the distal third intracellular loop of the mu-opioid receptor is required for G protein activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Molecular mechanisms of opioid receptor signal transduction.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

8 July 2018

1 reference

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Molecular biology of opioid receptors: recent advances.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Selective interactions of mu-opioid receptors with pertussis toxin-sensitive G proteins: involvement of the third intracellular loop and the c-terminal tail in coupling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Mu opioid receptor gene variants: lack of association with alcohol dependence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Morphine receptors as regulators of adenylate cyclase activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Conformational ensemble view of G protein-coupled receptors and the effect of mutations and ligand binding

8 July 2018

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Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse.

21 January 2018

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Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors

21 January 2018

1 reference

Distinct domains of the mu-opioid receptor control uncoupling and internalization

21 January 2018

1 reference

Ligand-selective activation of mu-oid receptor: demonstrated with deletion and single amino acid mutations of third intracellular loop domain

21 January 2018

1 reference

Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addiction

21 January 2018

1 reference

A genetic association study of the mu opioid receptor and severe opioid dependence

21 January 2018

1 reference

Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction

21 January 2018

1 reference

Facing up to the prescription opioid crisis

21 January 2018

1 reference

Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence

21 January 2018

1 reference

A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin

21 January 2018

1 reference

A continuous, fluorescence-based assay of μ-opioid receptor activation in AtT-20 cells

21 January 2018

1 reference

A real-time, fluorescence-based assay for measuring μ-opioid receptor modulation of adenylyl cyclase activity in Chinese hamster ovary cells

21 January 2018

1 reference

A118G Mu Opioid Receptor polymorphism increases inhibitory effects on CaV2.2 channels

21 January 2018

1 reference

Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human micro-opioid receptors (hMORs) containing the A118G single-nucleotide polymorphism

21 January 2018

1 reference

A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain

21 January 2018

1 reference

Genetic-epigenetic interaction modulates μ-opioid receptor regulation

21 January 2018

1 reference

Genetic analysis of the mu-opioid receptor in alcohol-dependent individuals

21 January 2018

1 reference

Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin

21 January 2018

1 reference

Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations

21 January 2018

1 reference

Differences in conformational properties of the second intracellular loop (IL2) in 5HT(2C) receptors modified by RNA editing can account for G protein coupling efficiency

21 January 2018

1 reference

Differential Effects of Agonists on Adenylyl Cyclase Superactivation Mediated by the κ Opioid Receptors: Adenylyl Cyclase Superactivation Is Independent of Agonist-Induced Phosphorylation, Desensitization, Internalization, and Down-Regulation

21 January 2018

1 reference

Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4292952

Familial Transmission of Substance Use Disorders

26 October 2018

1 reference

GPCR NaVa database: natural variants in human G protein-coupled receptors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24527749

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BPH.12644

1 reference

release_d2ukty26xzb5pifeayhgvawnoa

5 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d2ukty26xzb5pifeayhgvawnoa

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4292952

1 reference

5 August 2017

1 reference