(Q34949156)

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Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation

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scholarly article

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Europe PubMed Central

5 August 2017

Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation (English)

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Europe PubMed Central

5 August 2017

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Moutusi Manna

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Chaitali Mukhopadhyay

2

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Europe PubMed Central

5 August 2017

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publication date

9 August 2013

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Europe PubMed Central

5 August 2017

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Europe PubMed Central

5 August 2017

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Europe PubMed Central

5 August 2017

8

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Europe PubMed Central

5 August 2017

e71308

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Europe PubMed Central

5 August 2017

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Creative Commons Attribution 4.0 International

9 August 2013

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April 2022 Public Data File from Crossref

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Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

GM1 cluster mediates formation of toxic Aβ fibrils by providing hydrophobic environments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Dimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): an explicit-solvent molecular dynamics study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Atomic View of a Toxic Amyloid Small Oligomer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Cholesterol driven alteration of the conformation and dynamics of phospholamban in model membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Role of water in protein aggregation and amyloid polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Molecular dynamics simulations reveal the protective role of cholesterol in β-amyloid protein-induced membrane disruptions in neuronal membrane mimics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Spectroscopic Characterization of Intermolecular Interaction of Amyloid β Promoted on GM1 Micelles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Interactions of Aβ25-35 β-barrel-like oligomers with anionic lipid bilayer and resulting membrane leakage: an all-atom molecular dynamics study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Transmembrane structures for Alzheimer's Aβ(1-42) oligomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Designed fluorescent probes reveal interactions between amyloid-beta(1-40) peptides and GM1 gangliosides in micelles and lipid vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Amyloid peptide pores and the beta sheet conformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

A molecular dynamics study of the early stages of amyloid-beta(1-42) oligomerization: the role of lipid membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

NMR characterization of the interactions between lyso-GM1 aqueous micelles and amyloid beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Structures and free-energy landscapes of the wild type and mutants of the Abeta(21-30) peptide are determined by an interplay between intrapeptide electrostatic and hydrophobic interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Physicochemical interactions of amyloid beta-peptide with lipid bilayers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Assessing the nature of lipid raft membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Role of lipid charge in organization of water/lipid bilayer interface: insights via computer simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Binding of amyloid beta-peptide to ganglioside micelles is dependent on histidine-13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Stabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

VMD: visual molecular dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Functional roles of gangliosides in bio-signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739818

8 July 2018

Dimerization of the full-length Alzheimer amyloid β-peptide (Aβ42) in explicit aqueous solution: a molecular dynamics study

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

Cause and effect of melittin-induced pore formation: a computational approach.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

Structural diversity of dimers of the Alzheimer amyloid-beta(25-35) peptide and polymorphism of the resulting fibrils.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

Multidimensional view of amyloid fibril nucleation in atomistic detail.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

Amyloid β peptides aggregation in a mixed membrane bilayer: a molecular dynamics study.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

Molecular level investigation of organization in ternary lipid bilayer: a computational approach

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21 January 2018

GROMACS: A message-passing parallel molecular dynamics implementation

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21 January 2018

Molecular dynamics simulations of stratum corneum lipid models: fatty acids and cholesterol

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation

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21 January 2018

GM1 ganglioside embedded in a hydrated DOPC membrane: a molecular dynamics simulation study.

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21 January 2018

Perturbation of membranes by the amyloid beta-peptide--a molecular dynamics study

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21 January 2018

Cholesterol promotes the interaction of Alzheimer β-amyloid monomer with lipid bilayer.

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21 January 2018

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

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21 January 2018

Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid

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26 October 2018

Ganglioside GM1-Mediated Amyloid-beta Fibrillogenesis and Membrane Disruption†

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071308

21 January 2018

GROMACS 3.0: a package for molecular simulation and trajectory analysis

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21 January 2018

Molecular dynamics with coupling to an external bath

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21 January 2018

Molecular Interactions of Alzheimer's Aβ Protofilaments with Lipid Membranes

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21 January 2018

Comparative Molecular Dynamics Study of Aβ Adsorption on the Self-Assembled Monolayers

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21 January 2018

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

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https://pubmed.ncbi.nlm.nih.gov/23951128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanism of β-sheet self-organization at water-hydrophobic interfaces

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide oligomerization in silico: dimer and trimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disordered versus fibril-like amyloid β (25-35) dimers in water: structure and thermodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the amyloid-beta (1-42) monomer absorbed to model phospholipid bilayers: a molecular dynamics study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dynamics simulations of the interactions of kinin peptides with an anionic POPG bilayer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0071308

1 reference

Europe PubMed Central

5 August 2017

2013PLoSO...871308M

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1 reference

Europe PubMed Central

5 August 2017

1 reference

Europe PubMed Central

5 August 2017

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