(Q34972819)

5 August 2017

1 reference

title

Emerging functions of p21-activated kinases in human cancer cells (English)

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5 August 2017

Rakesh Kumar

1

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PubMed ID

12384990

5 August 2017

Ratna K Vadlamudi

series ordinal

2

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5 August 2017

1 November 2002

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Journal of Cellular Physiology

5 August 2017

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5 August 2017

193

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5 August 2017

2

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5 August 2017

133-144

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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

5 August 2017

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Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

21 January 2018

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Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

21 January 2018

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Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

21 January 2018

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Effectors for the Rho GTPases

21 January 2018

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Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis

21 January 2018

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Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells

21 January 2018

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21 January 2018

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A novel regulator of p21-activated kinases

21 January 2018

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Identification of a mouse p21Cdc42/Rac activated kinase

21 January 2018

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A novel kinase activity associated with Nef derived from neurovirulent simian immunodeficiency virus

21 January 2018

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Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma

21 January 2018

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Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

21 January 2018

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A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

21 January 2018

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p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I

21 January 2018

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Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

21 January 2018

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A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization

21 January 2018

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Direct binding and In vivo regulation of the fission yeast p21-activated kinase shk1 by the SH3 domain protein scd2.

21 January 2018

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Signaling to chromatin through histone modifications

21 January 2018

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PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis

21 January 2018

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

21 January 2018

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Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16

21 January 2018

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Regulation of macropinocytosis by p21-activated kinase-1

21 January 2018

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

21 January 2018

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Control of G2/M transition in Xenopus by a member of the p21-activated kinase (PAK) family: a link between protein kinase A and PAK signaling pathways?

21 January 2018

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Modulation of the organ microenvironment for treatment of cancer metastasis

21 January 2018

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Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

21 January 2018

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Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

21 January 2018

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Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

21 January 2018

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Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

21 January 2018

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Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2

21 January 2018

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Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK)

21 January 2018

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Rho GTPases and the actin cytoskeleton

21 January 2018

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

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Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3.

21 January 2018

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Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases

21 January 2018

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Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

21 January 2018

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p21-activated kinases: three more join the Pak.

21 January 2018

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Substrates enhance autophosphorylation and activation of p21-activated protein kinase gamma-PAK in the absence of activation loop phosphorylation

21 January 2018

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p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts

21 January 2018

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Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

21 January 2018

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Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

21 January 2018

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p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

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Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

21 January 2018

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A role for p21-activated kinase in endothelial cell migration.

21 January 2018

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The p21Rac/Cdc42-activated kinases (PAKs).

21 January 2018

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The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia

21 January 2018

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Pheromone signalling and polarized morphogenesis in yeast

21 January 2018

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Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

21 January 2018

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BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling

21 January 2018

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AR and ER interaction with a p21-activated kinase (PAK6)

21 January 2018

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

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p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

21 January 2018

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Antagonists of calcium fluxes and calmodulin block activation of the p21-activated protein kinases in neutrophils

21 January 2018

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Mechanism of activation of Pak1 kinase by membrane localization

21 January 2018

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

21 January 2018

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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

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An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex

21 January 2018

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Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

21 January 2018

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

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The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic

21 January 2018

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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

21 January 2018

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Identification of the Nef-associated kinase as p21-activated kinase 2

21 January 2018

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

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p21-activated Protein Kinase γ-PAK Is Activated by Ionizing Radiation and Other DNA-damaging Agents

21 January 2018

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Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

21 January 2018

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Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

21 January 2018

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Inhibition of myosin light chain kinase by p21-activated kinase

21 January 2018

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Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

21 January 2018

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Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK.

21 January 2018

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p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

21 January 2018

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p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

21 January 2018

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

21 January 2018

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Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

21 January 2018

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Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts

21 January 2018

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Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts

21 January 2018

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Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

21 January 2018

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Cell cycle-regulated phosphorylation of p21-activated kinase 1.

21 January 2018

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Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

21 January 2018

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Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

21 January 2018

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Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

21 January 2018

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Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1

21 January 2018

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p21-activated kinase links Rac/Cdc42 signaling to merlin

21 January 2018

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Constitutive activation of endocytosis by mutation of myoA, the myosin I gene of Aspergillus nidulans.

21 January 2018

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alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

21 January 2018

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Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation

21 January 2018

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Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

21 January 2018

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Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

21 January 2018

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Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

21 January 2018

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Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.

21 January 2018

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Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

21 January 2018

1 reference

Cell Cycle- and Cln2p-Cdc28p-dependent Phosphorylation of the Yeast Ste20p Protein Kinase

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCP.10167

1 reference

5 August 2017

1 reference

PubMed ID

12384990