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Identification of potential synthetic lethal genes to p53 using a computational biology approach
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Europe PubMed Central
PMCID
3847148
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
title
Identification of potential synthetic lethal genes to p53 using a computational biology approach
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
main subject
RNA sequencing
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computational biology
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author
Xiaosheng Wang
series ordinal
1
1 reference
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Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
author name string
Richard Simon
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2
1 reference
stated in
Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
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20 February 2020
publication date
11 September 2013
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Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
published in
BMC Medical Genomics
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Europe PubMed Central
PMCID
3847148
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
volume
6
1 reference
stated in
Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
page(s)
30
1 reference
stated in
Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
exact match
https://scigraph.springernature.com/pub.10.1186/1755-8794-6-30
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Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment
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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
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p53-dependent apoptosis in response to spindle damage is linked to loss of Bub1.
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A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy
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Integrated genomic and pharmacological approaches to identify synthetic lethal genes as cancer therapeutic targets
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8 July 2018
Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation
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Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.
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TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
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8 July 2018
Surveillance mechanism linking Bub1 loss to the p53 pathway
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8 July 2018
Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.
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8 July 2018
Transcription regulation by mutant p53.
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8 July 2018
Restoration of p53 function leads to tumour regression in vivo
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8 July 2018
Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.
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8 July 2018
Gene expression patterns associated with p53 status in breast cancer.
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8 July 2018
Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
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8 July 2018
RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene
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8 July 2018
Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression
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8 July 2018
Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells
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8 July 2018
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.
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8 July 2018
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features
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8 July 2018
RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation
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8 July 2018
Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.
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8 July 2018
The concept of synthetic lethality in the context of anticancer therapy
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8 July 2018
The coordinate regulation of the p53 and mTOR pathways in cells
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8 July 2018
Protein kinase C (PKC) family in cancer progression
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8 July 2018
Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells
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8 July 2018
Upstream and downstream of mTOR
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8 July 2018
Aurora A, meiosis and mitosis
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Polo-like kinases and the orchestration of cell division
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8 July 2018
Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.
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8 July 2018
The functional interactions between the p53 and MAPK signaling pathways
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8 July 2018
Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development
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8 July 2018
Targeting mTOR signaling for cancer therapy
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8 July 2018
Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells
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8 July 2018
Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease
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8 July 2018
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
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8 July 2018
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
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8 July 2018
Control of the eukaryotic cell cycle by MAP kinase signaling pathways.
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8 July 2018
The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.
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8 July 2018
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.
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8 July 2018
DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis
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8 July 2018
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148
retrieved
8 July 2018
A serine kinase regulates intracellular localization of splicing factors in the cell cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148
retrieved
8 July 2018
Gene transfer of wild-type p53 results in restoration of tumor-suppressor function in a medulloblastoma cell line.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148
retrieved
8 July 2018
Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148
retrieved
8 July 2018
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148
retrieved
8 July 2018
p53 mutations in human cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148
retrieved
8 July 2018
Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2F1755-8794-6-30
retrieved
21 January 2018
Targeting the protein kinase C family: are we there yet?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2F1755-8794-6-30
retrieved
21 January 2018
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24025726
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Restoration of the transcription activation function to mutant p53 in human cancer cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24025726
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1186/1755-8794-6-30
1 reference
stated in
Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
Dimensions Publication ID
1020989289
0 references
PMCID
3847148
1 reference
stated in
Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
PubMed ID
24025726
1 reference
stated in
Europe PubMed Central
PMCID
3847148
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
ResearchGate publication ID
256500435
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