(Q35128112)

English

The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

endoplasmic reticulum

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Chandra L Theesfeld

1

object named as

Chandra L Theesfeld

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

author name string

Deeba Pourmand

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Talib Davis

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Renee M Garza

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Randolph Y Hampton

5

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Europe PubMed Central

PubMed publication ID

6 August 2017

language of work or name

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publication date

31 May 2011

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Europe PubMed Central

PubMed publication ID

6 August 2017

number of pages

10

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

6 August 2017

286

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

30

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

26298-26307

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Protein sensors for membrane sterols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Measuring protein degradation with green fluorescent protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

A 'distributed degron' allows regulated entry into the ER degradation pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Genetic and biochemical evaluation of eucaryotic membrane protein topology: multiple transmembrane domains of Saccharomyces cerevisiae 3-hydroxy-3-methylglutaryl coenzyme A reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Regulation of the mevalonate pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143592

28 July 2018

Regulation of sterol synthesis in eukaryotes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

An improved classification of G-protein-coupled receptors using sequence-derived features.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

The sterol-sensing domain: multiple families, a unique role?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Lipid-mediated, reversible misfolding of a sterol-sensing domain protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.244798

21 January 2018

Identifiers

10.1074/JBC.M111.244798

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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