(Q35129694)

6 August 2017

1 reference

title

Caspases and T lymphocytes: a flip of the coin? (English)

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6 August 2017

Saquib Lakhani

1

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Richard Flavell

series ordinal

2

object named as

Richard A Flavell

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6 August 2017

publication date

1 June 2003

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6 August 2017

published in

Immunological Reviews

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6 August 2017

volume

193

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6 August 2017

page(s)

22-30

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

6 August 2017

cites work

1 reference

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Genetic control of programmed cell death in the nematode C. elegans.

21 January 2018

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Phagocytosis promotes programmed cell death in C. elegans

21 January 2018

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Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

21 January 2018

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Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

21 January 2018

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

21 January 2018

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Structure and mechanism of interleukin-1 beta converting enzyme

21 January 2018

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Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta-converting enzyme precursor

21 January 2018

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Mechanisms mediating caspase activation in cell death

21 January 2018

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The short prodomain influences caspase-3 activation in HeLa cells

21 January 2018

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Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

21 January 2018

1 reference

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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Caspase-10 is an initiator caspase in death receptor signaling

21 January 2018

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Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

21 January 2018

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An induced proximity model for caspase-8 activation.

21 January 2018

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Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

1 reference

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Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Caspase-9 and APAF-1 form an active holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Caspase-9 can be activated without proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Differential requirement for caspase 9 in apoptotic pathways in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Interferon gamma is required for activation-induced death of T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Regulation of lymphocyte proliferation and death by FLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Inhibition of death receptor signals by cellular FLIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Casper is a FADD- and caspase-related inducer of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

A dominant negative Fas-associated death domain protein mutant inhibits proliferation and leads to impaired calcium mobilization in both T-cells and fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Caspase activation is required for T cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Defective T Cell Differentiation in the Absence of Jnk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Inhibition of nuclear transport of caspase-7 by its prodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Role of mitogen-activated protein kinases in activation-induced apoptosis of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Activation of caspase-3-like enzymes in non-apoptotic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Interleukin-2: inception, impact, and implications

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Chronic lymphadenopathy simulating malignant lymphoma

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

Fas transduces activation signals in normal human T lymphocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00046.X

7 January 2021

10.1034/J.1600-065X.2003.00046.X

Identifiers

DOI

1 reference

6 August 2017

1 reference