(Q35141764)

6 August 2017

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title

The present view of the mechanism of protein folding (English)

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6 August 2017

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2

Alan Fersht

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6 August 2017

1

Valerie Daggett

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6 August 2017

1 June 2003

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Nature Reviews Molecular Cell Biology

6 August 2017

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6 August 2017

4

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6 August 2017

497-502

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6 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrm1126

6 August 2017

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Protein folding and unfolding at atomic resolution

31 March 2020

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Protein unfolding--an important process in vivo?

31 March 2020

1 reference

31 March 2020

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Towards an understanding of amyloidogenesis

31 March 2020

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Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding

31 March 2020

1 reference

31 March 2020

Protein-folding dynamics

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Nucleation, rapid folding, and globular intrachain regions in proteins

31 March 2020

1 reference

Is there a unifying mechanism for protein folding?

31 March 2020

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The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding

31 March 2020

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Characterization of the transition state of protein unfolding by use of molecular dynamics: chymotrypsin inhibitor 2

31 March 2020

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"New view" of protein folding reconciled with the old through multiple unfolding simulations.

31 March 2020

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Increasing temperature accelerates protein unfolding without changing the pathway of unfolding.

31 March 2020

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The molecular basis for the chemical denaturation of proteins by urea

31 March 2020

1 reference

Protein folding from a highly disordered denatured state: the folding pathway of chymotrypsin inhibitor 2 at atomic resolution

31 March 2020

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Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding

31 March 2020

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Characterization of residual structure in the thermally denatured state of barnase by simulation and experiment: description of the folding pathway

31 March 2020

1 reference

Molecular dynamics simulation of the unfolding of barnase: characterization of the major intermediate.

31 March 2020

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The complete folding pathway of a protein from nanoseconds to microseconds

31 March 2020

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Simulations of the structural and dynamical properties of denatured proteins: the "molten coil" state of bovine pancreatic trypsin inhibitor.

31 March 2020

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High populations of non-native structures in the denatured state are compatible with the formation of the native folded state

31 March 2020

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Effects of topology and excluded volume on protein denatured state conformational properties

31 March 2020

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Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

31 March 2020

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Evidence for sequential barriers and obligatory intermediates in apparent two-state protein folding

31 March 2020

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Structure of the transition state for folding of a protein derived from experiment and simulation.

31 March 2020

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Determination of a transition state at atomic resolution from protein engineering data

31 March 2020

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Self-consistent determination of the transition state for protein folding: application to a fibronectin type III domain

31 March 2020

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How the folding rate constant of simple, single-domain proteins depends on the number of native contacts

31 March 2020

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Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism

31 March 2020

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Long-range order in the src SH3 folding transition state

31 March 2020

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NMR and SAXS characterization of the denatured state of the chemotactic protein CheY: implications for protein folding initiation

31 March 2020

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Comparison of the folding processes of T. thermophilus and E. coli ribonucleases H.

31 March 2020

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31 March 2020

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Early kinetic intermediate in the folding of acyl-CoA binding protein detected by fluorescence labeling and ultrarapid mixing

31 March 2020

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Pathways to a protein folding intermediate observed in a 1-microsecond simulation in aqueous solution

31 March 2020

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Absolute comparison of simulated and experimental protein-folding dynamics

31 March 2020

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On the simulation of protein folding by short time scale molecular dynamics and distributed computing

31 March 2020

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Mechanical and chemical unfolding of a single protein: a comparison

31 March 2020

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The key event in force-induced unfolding of Titin's immunoglobulin domains

31 March 2020

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Unfolding proteins by external forces and temperature: the importance of topology and energetics

31 March 2020

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Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state

31 March 2020

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The effect of core destabilization on the mechanical resistance of I27.

31 March 2020

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Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering

31 March 2020

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Direct observation of better hydration at the N terminus of an alpha-helix with glycine rather than alanine as the N-cap residue

31 March 2020

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Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy

31 March 2020

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Structural studies of the engrailed homeodomain

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1126

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6 August 2017

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PubMed ID

12778129