(Q35188726)

7 August 2017

title

Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists (English)

1 reference

7 August 2017

Harald Lanig

3

0 references

Peter Gmeiner

object named as

Peter Gmeiner

series ordinal

5

0 references

Timothy Clark

object named as

Timothy Clark

series ordinal

4

0 references

Ralf C Kling

series ordinal

1

object named as

Ralf C Kling

1 reference

7 August 2017

Nuska Tschammer

2

1 reference

7 August 2017

language of work or name

English

0 references

publication date

16 June 2014

1 reference

7 August 2017

1 reference

7 August 2017

volume

9

1 reference

7 August 2017

issue

6

1 reference

7 August 2017

page(s)

e100069

1 reference

Creative Commons Attribution 4.0 International

7 August 2017

copyright license

start time

16 June 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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13 July 2018

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Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

13 July 2018

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Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

13 July 2018

1 reference

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Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.

13 July 2018

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Lifting the lid on GPCRs: the role of extracellular loops

13 July 2018

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

13 July 2018

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Helix 8 of the M1 muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site.

13 July 2018

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Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates

13 July 2018

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

13 July 2018

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Structure and function of an irreversible agonist-β(2) adrenoceptor complex

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

13 July 2018

1 reference

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Highly conserved tyrosine stabilizes the active state of rhodopsin

13 July 2018

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Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

13 July 2018

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A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

13 July 2018

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13 July 2018

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Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.

13 July 2018

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Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics.

13 July 2018

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Heterotrimeric G protein activation by G-protein-coupled receptors

13 July 2018

1 reference

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The evasive nature of drug efficacy: implications for drug discovery

13 July 2018

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The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

13 July 2018

1 reference

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Molecular mechanism of 7TM receptor activation--a global toggle switch model

13 July 2018

1 reference

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GROMACS: fast, flexible, and free

13 July 2018

1 reference

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The carboxyl terminus of the Galpha-subunit is the latch for triggered activation of heterotrimeric G proteins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

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13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Aripiprazole: a comprehensive review of its pharmacology, clinical efficacy, and tolerability

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Development and testing of a general amber force field

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Seven-transmembrane receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Efficacy at G-protein-coupled receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Effect of multiple serine/alanine mutations in the transmembrane spanning region V of the D2 dopamine receptor on ligand binding

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Investigation of the role of conserved serine residues in the long form of the rat D2 dopamine receptor using site-directed mutagenesis.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Hydrophobic Residues of the D2 Dopamine Receptor Are Important for Binding and Signal Transduction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Pharmacological profile of 2-bromoterguride at human dopamine D2, porcine serotonin 5-hydroxytryptamine 2A, and α2C-adrenergic receptors, and its antipsychotic-like effects in rats

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

The role of conformational ensembles in ligand recognition in G-protein coupled receptors.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Conserved Tyr223(5.58) plays different roles in the activation and G-protein interaction of rhodopsin.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Induction of the tetracycline repressor: characterization by molecular-dynamics simulations.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059746

The missing term in effective pair potentials

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0100069

Molecular Dynamics Simulations of the Effect of the G-Protein and Diffusible Ligands on the β2-Adrenergic Receptor

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0100069

Biomolecular simulations of membranes: Physical properties from different force fields

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24932547

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/24932547

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amphipathic alpha-helical structure does not predict the ability of receptor-derived synthetic peptides to interact with guanine nucleotide-binding regulatory proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24932547

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0100069

1 reference

7 August 2017

0 references

1 reference

7 August 2017

1 reference