(Q35190150)

7 August 2017

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title

The genetics of malignant melanoma: lessons from mouse and man. (English)

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7 August 2017

1

Lynda Chin

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PubMed ID

12894244

7 August 2017

language of work or name

English

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publication date

1 August 2003

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7 August 2017

Nature Reviews Cancer

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7 August 2017

3

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7 August 2017

8

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7 August 2017

559-570

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https://scigraph.springernature.com/pub.10.1038/nrc1145

7 August 2017

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations

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Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair

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Cyclic AMP a key messenger in the regulation of skin pigmentation.

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Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival.

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Mutagenicity of melanin from human red hair

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Melanocortin 1 Receptor (MC1R) Gene Variants are Associated with an Increased Risk for Cutaneous Melanoma Which is Largely Independent of Skin Type and Hair Color

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31 March 2020

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31 March 2020

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Mechanisms of ultraviolet light-induced pigmentation

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Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes

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Development of melanocyte precursors from the vertebrate neural crest.

31 March 2020

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Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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High frequency of BRAF mutations in nevi

31 March 2020

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Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

31 March 2020

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Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development

31 March 2020

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Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression

31 March 2020

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31 March 2020

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

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31 March 2020

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31 March 2020

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

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31 March 2020

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Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

31 March 2020

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Geographical variation in the penetrance of CDKN2A mutations for melanoma

31 March 2020

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Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

31 March 2020

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31 March 2020

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31 March 2020

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Essential role for oncogenic Ras in tumour maintenance

31 March 2020

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Angiogenesis, lymphangiogenesis, and melanoma metastasis

31 March 2020

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E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors

31 March 2020

1 reference

CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

1 reference

Transcriptional repression. The cancer-chromatin connection

31 March 2020

1 reference

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

31 March 2020

1 reference

E1A signaling to p53 involves the p19(ARF) tumor suppressor

31 March 2020

1 reference

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

1 reference

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

31 March 2020

1 reference

Mammalian MAP kinase signalling cascades

31 March 2020

1 reference

Genetics, development, and malignancy of melanocytes.

31 March 2020

1 reference

Melanoma development and progression: a conspiracy between tumor and host

31 March 2020

1 reference

Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system

31 March 2020

1 reference

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

31 March 2020

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p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma

31 March 2020

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Cellular senescence: mitotic clock or culture shock?

31 March 2020

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Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection

31 March 2020

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Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

31 March 2020

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alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome

31 March 2020

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Distinct requirements for Ras oncogenesis in human versus mouse cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1145

1 reference

7 August 2017

1 reference

PubMed ID

12894244