(Q35190150)

7 August 2017

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title

The genetics of malignant melanoma: lessons from mouse and man. (English)

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7 August 2017

1

Lynda Chin

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7 August 2017

language of work or name

English

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publication date

1 August 2003

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7 August 2017

published in

Nature Reviews Cancer

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7 August 2017

volume

3

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7 August 2017

issue

8

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7 August 2017

page(s)

559-570

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The epidemiology of UV induced skin cancer

7 August 2017

cites work

1 reference

The pathogenesis of melanoma induced by ultraviolet radiation

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Trends in the incidence of cutaneous malignant melanoma in New South Wales, 1983-1996.

31 March 2020

1 reference

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

31 March 2020

1 reference

A cell cycle regulator potentially involved in genesis of many tumor types

31 March 2020

1 reference

Germline p16 mutations in familial melanoma

31 March 2020

1 reference

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

31 March 2020

1 reference

Cell-cycle regulators and cancer

31 March 2020

1 reference

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

1 reference

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

31 March 2020

1 reference

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

31 March 2020

1 reference

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

31 March 2020

1 reference

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

31 March 2020

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

31 March 2020

1 reference

CDKN2A Variants in a Population-Based Sample of Queensland Families With Melanoma

31 March 2020

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Low prevalence of germline CDKN2A and CDK4 mutations in patients with early-onset melanoma

31 March 2020

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Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma

31 March 2020

1 reference

Locoregional treatment of low-grade B-cell lymphoma with CD3xCD19 bispecific antibodies and CD28 costimulation. II. Assessment of cellular immune responses

31 March 2020

1 reference

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

31 March 2020

1 reference

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

31 March 2020

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Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

31 March 2020

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Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

31 March 2020

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Genotype-Phenotype Relationships in U.S. Melanoma-Prone Families With CDKN2A and CDK4 Mutations

31 March 2020

1 reference

Invasive melanoma in Cdk4-targeted mice

31 March 2020

1 reference

p16/CDKN2 andCDK4 gene mutations in sporadic melanoma development and progression

31 March 2020

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Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase

31 March 2020

1 reference

A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family

31 March 2020

1 reference

A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.

31 March 2020

1 reference

Frequent aberrant methylation of p16INK4a in primary rat lung tumors

31 March 2020

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Cloning and characterization of the CDKN2A and p19ARF genes from Monodelphis domestica

31 March 2020

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Role of the INK4a locus in tumor suppression and cell mortality.

31 March 2020

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Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

31 March 2020

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Genetic dissection of melanoma pathways in the mouse

31 March 2020

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Malignant melanoma in transgenic mice.

31 March 2020

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Dual inactivation of RB and p53 pathways in RAS-induced melanomas

31 March 2020

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

31 March 2020

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Expression of c-myc oncoprotein represents a new prognostic marker in cutaneous melanoma

31 March 2020

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Extra c-myc oncogene copies in high risk cutaneous malignant melanoma and melanoma metastases

31 March 2020

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

31 March 2020

1 reference

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

31 March 2020

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

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Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo.

31 March 2020

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Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans

31 March 2020

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Skin colour and skin cancer - MC1R, the genetic link

31 March 2020

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Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair

31 March 2020

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Melanocortin 1 receptor variants in an Irish population

31 March 2020

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Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation

31 March 2020

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Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype?

31 March 2020

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The melanocortin-1-receptor gene is the major freckle gene

31 March 2020

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MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations

31 March 2020

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Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair

31 March 2020

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Cyclic AMP a key messenger in the regulation of skin pigmentation.

31 March 2020

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Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival.

31 March 2020

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Mutagenicity of melanin from human red hair

31 March 2020

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Melanocortin 1 Receptor (MC1R) Gene Variants are Associated with an Increased Risk for Cutaneous Melanoma Which is Largely Independent of Skin Type and Hair Color

31 March 2020

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Melanocortin-1 receptor variant R151C modifies melanoma risk in Dutch families with melanoma.

31 March 2020

1 reference

Genetics of melanoma predisposition

31 March 2020

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

31 March 2020

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Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes.

31 March 2020

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Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

31 March 2020

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Integration of signals from receptor tyrosine kinases and g protein-coupled receptors.

31 March 2020

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Mechanisms of ultraviolet light-induced pigmentation

31 March 2020

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Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes

31 March 2020

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Development of melanocyte precursors from the vertebrate neural crest.

31 March 2020

1 reference

Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma

31 March 2020

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Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.

31 March 2020

1 reference

Mutational analysis of N-ras, p53, CDKN2A (p16(INK4a)), p14(ARF), CDK4, and MC1R genes in human dysplastic melanocytic naevi

31 March 2020

1 reference

Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-ras gene regulated by a mouse tyrosinase promoter.

31 March 2020

1 reference

Mutations of the BRAF gene in human cancer

31 March 2020

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RAF/RAS oncogenes and mismatch-repair status

31 March 2020

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High frequency of BRAF mutations in nevi

31 March 2020

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Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

31 March 2020

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Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development

31 March 2020

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Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression

31 March 2020

1 reference

PTEN signaling pathways in melanoma

31 March 2020

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

1 reference

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

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In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma

31 March 2020

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Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene

31 March 2020

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

31 March 2020

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Germline mutations in PTEN are present in Bannayan-Zonana syndrome

31 March 2020

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Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

31 March 2020

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Pten is essential for embryonic development and tumour suppression

31 March 2020

1 reference

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

31 March 2020

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Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

31 March 2020

1 reference

Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth

31 March 2020

1 reference

Influence of sun exposures during childhood and during adulthood on melanoma risk. EPIMEL and EORTC Melanoma Cooperative Group. European Organisation for Research and Treatment of Cancer

31 March 2020

1 reference

Photocarcinogenesis in human adult skin grafts

31 March 2020

1 reference

UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells

31 March 2020

1 reference

UV Fingerprint CDKN2a but No p14ARF Mutations in Sporadic Melanomas

31 March 2020

1 reference

UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer

31 March 2020

1 reference

The fundamental role of epigenetic events in cancer

31 March 2020

1 reference

Neonatal sunburn and melanoma in mice

31 March 2020

1 reference

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

31 March 2020

1 reference

Geographical variation in the penetrance of CDKN2A mutations for melanoma

31 March 2020

1 reference

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

31 March 2020

1 reference

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

31 March 2020

1 reference

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

31 March 2020

1 reference

Cancer revoked: oncogenes as therapeutic targets

31 March 2020

1 reference

Essential role for oncogenic Ras in tumour maintenance

31 March 2020

1 reference

Angiogenesis, lymphangiogenesis, and melanoma metastasis

31 March 2020

1 reference

E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors

31 March 2020

1 reference

CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

1 reference

Transcriptional repression. The cancer-chromatin connection

31 March 2020

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

31 March 2020

1 reference

E1A signaling to p53 involves the p19(ARF) tumor suppressor

31 March 2020

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

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p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

31 March 2020

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Mammalian MAP kinase signalling cascades

31 March 2020

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Genetics, development, and malignancy of melanocytes.

31 March 2020

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Melanoma development and progression: a conspiracy between tumor and host

31 March 2020

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Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system

31 March 2020

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Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

31 March 2020

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p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma

31 March 2020

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Cellular senescence: mitotic clock or culture shock?

31 March 2020

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Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection

31 March 2020

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Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

31 March 2020

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alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome

31 March 2020

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Distinct requirements for Ras oncogenesis in human versus mouse cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1145

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7 August 2017

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