(Q35197299)

7 August 2017

Computational library design for increasing haloalkane dehalogenase stability (English)

1 reference

7 August 2017

7

Ben L Feringa

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Hein J Wijma

object named as

Hein J Wijma

2

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Siewert J Marrink

object named as

Siewert J Marrink

8

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author name string

Robert J Floor

1

1 reference

7 August 2017

Dana I Colpa

3

1 reference

7 August 2017

Aline Ramos-Silva

4

1 reference

7 August 2017

Peter A Jekel

5

1 reference

7 August 2017

Wiktor Szymański

6

1 reference

7 August 2017

Dick B Janssen

9

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7 August 2017

27 June 2014

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7 August 2017

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7 August 2017

15

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7 August 2017

1660-1672

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7 August 2017

11

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Protein stability promotes evolvability

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Relative tolerance of mesostable and thermostable protein homologs to extensive mutation

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Directed evolution of enzyme stability

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The consensus concept for thermostability engineering of proteins

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Selection of mutations for increased protein stability

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Novel protease inhibitors via computational redesign of subtilisin BPN' propeptide

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Role of conformational sampling in computing mutation-induced changes in protein structure and stability

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Engineering a disulfide bond in the lid hinge region of Rhizopus chinensis lipase: increased thermostability and altered acyl chain length specificity

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Enhancing thermostability of a Rhizomucor miehei lipase by engineering a disulfide bond and displaying on the yeast cell surface.

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Disulfide by Design™: a computational method for the rational design of disulfide bonds in proteins

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Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details.

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Assessing predictors of changes in protein stability upon mutation using self-consistency

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Quantitative analysis of substrate specificity of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26.

21 January 2018

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Cloning and sequencing of a dehalogenase gene encoding an enzyme with hydrolase activity involved in the degradation of gamma-hexachlorocyclohexane in Pseudomonas paucimobilis

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Degradation of beta-hexachlorocyclohexane by haloalkane dehalogenase LinB from gamma-hexachlorocyclohexane-utilizing bacterium Sphingobium sp. MI1205.

21 January 2018

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Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry

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Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates

21 January 2018

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A single mutation in a tunnel to the active site changes the mechanism and kinetics of product release in haloalkane dehalogenase LinB.

21 January 2018

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Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis

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Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel

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Computational protein design with explicit consideration of surface hydrophobic patches

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Protein stability curves

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Mathematics, thermodynamics, and modeling to address ten common misconceptions about protein structure, folding, and stability

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Biophysical characterization of mutants ofBacillus subtilislipase evolved for thermostability: Factors contributing to increased activity retention

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Dynameomics: large-scale assessment of native protein flexibility

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Functionally relevant motions of haloalkane dehalogenases occur in the specificity-modulating cap domains

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Characterization of a solvent resistant and thermostable aminopeptidase from the hyperthermophillic bacterium, Aquifex aeolicus.

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A thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents

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Variations in the stability of NCR ene reductase by rational enzyme loop modulation.

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Effect of dioxane on the structure and hydration-dehydration of alpha-chymotrypsin as measured by FTIR spectroscopy

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Display of a thermostable lipase on the surface of a solvent-resistant bacterium, Pseudomonas putida GM730, and its applications in whole-cell biocatalysis

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Molecular dynamics simulations as a tool for improving protein stability

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Crystal structure of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 A resolution: dynamics of catalytic residues

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Crystal Structure and Site-Directed Mutagenesis Analyses of Haloalkane Dehalogenase LinB from Sphingobium sp. Strain MI1205

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Catalytic mechanism of the maloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26.

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Purification and characterization of a haloalkane dehalogenase of a new substrate class from a gamma-hexachlorocyclohexane-degrading bacterium, Sphingomonas paucimobilis UT26

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Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26

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Organic co-solvents affect activity, stability and enantioselectivity of haloalkane dehalogenases

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Remarkable activity enhancement of thermolysin mutants

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Identifiers

DOI

10.1002/CBIC.201402128

1 reference

7 August 2017

1 reference