(Q35204878)

7 August 2017

title

Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice (English)

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7 August 2017

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Tomohiro Umeda

1

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7 August 2017

Hiroshi Eguchi

2

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7 August 2017

Yuichi Kunori

3

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7 August 2017

Yoichi Matsumoto

4

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7 August 2017

Taizo Taniguchi

5

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7 August 2017

Hiroshi Mori

6

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7 August 2017

Takami Tomiyama

7

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7 August 2017

publication date

9 January 2015

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Annals of clinical and translational neurology

7 August 2017

published in

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7 August 2017

volume

2

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7 August 2017

issue

3

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7 August 2017

page(s)

241-255

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describes a project that uses

7 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4369274/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Vaccination with Sarkosyl insoluble PHF-tau decrease neurofibrillary tangles formation in aged tau transgenic mouse model: a pilot study.

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Neuronal activity regulates extracellular tau in vivo

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Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

13 July 2018

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Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity

13 July 2018

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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

13 July 2018

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The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

13 July 2018

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Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

13 July 2018

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13 July 2018

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Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

13 July 2018

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Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

13 July 2018

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Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

13 July 2018

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Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

13 July 2018

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Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

13 July 2018

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The propagation of prion-like protein inclusions in neurodegenerative diseases

13 July 2018

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Prion-like transmission of protein aggregates in neurodegenerative diseases

13 July 2018

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Prion-like mechanisms in neurodegenerative diseases

13 July 2018

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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

13 July 2018

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Tauopathy models and human neuropathology: similarities and differences

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism

13 July 2018

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Tau suppression in a neurodegenerative mouse model improves memory function

13 July 2018

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Neurodegenerative tauopathies

13 July 2018

1 reference

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

13 July 2018

1 reference

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Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369274

26 September 2018

Identifiers

DOI

10.1002/ACN3.171

1 reference

7 August 2017

1 reference

7 August 2017

1 reference