(Q35515670)

English

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

scientific article published on April 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 August 2017

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Alzheimer's disease

0 references

cognitive dysfunction

1 reference

based on heuristic

inferred from title

Daniel Watterson

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Adam D Bachstetter

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Linda J Van Eldik

2

object named as

Linda J Van Eldik

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Scott J Webster

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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publication date

1 April 2015

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Europe PubMed Central

PubMed publication ID

8 August 2017

Journal of Neuroscience

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

35

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

16

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

6554-6569

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

1 reference

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Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

1 reference

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1 reference

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Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice

1 reference

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Microglial priming in neurodegenerative disease

1 reference

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Microglial dysfunction in brain aging and Alzheimer's disease

1 reference

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Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort

1 reference

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The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury

1 reference

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Identification of a unique TGF-β-dependent molecular and functional signature in microglia

1 reference

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Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain

1 reference

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Traumatic brain injury precipitates cognitive impairment and extracellular Aβ aggregation in Alzheimer's disease transgenic mice

1 reference

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The microglial sensome revealed by direct RNA sequencing

1 reference

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Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators

1 reference

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Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model

1 reference

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A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model

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Calcium dysregulation and neuroinflammation: discrete and integrated mechanisms for age-related synaptic dysfunction

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Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

1 reference

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Emerging roles of astrocytes in neural circuit development

1 reference

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Selective inhibition of microglia-mediated neuroinflammation mitigates radiation-induced cognitive impairment

1 reference

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The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.

1 reference

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The role of markers of inflammation in traumatic brain injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Animal models of traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

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Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

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Dementia resulting from traumatic brain injury: what is the pathology?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

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Genomic analysis of reactive astrogliosis

1 reference

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Neurological diseases as primary gliopathies: a reassessment of neurocentrism

1 reference

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12 July 2018

Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

1 reference

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Assessing burrowing, nest construction, and hoarding in mice

1 reference

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The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Astrocyte-neuron metabolic relationships: for better and for worse

1 reference

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12 July 2018

Role of microglia in neurotrauma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

12 July 2018

Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

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The regulation of IL-10 production by immune cells

1 reference

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Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405562

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Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.

1 reference

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Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.

1 reference

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TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

1 reference

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Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug

1 reference

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Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

1 reference

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Opposing roles for reactive astrocytes following traumatic brain injury

1 reference

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1 reference

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Modulation of immune response by head injury

1 reference

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1 reference

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1 reference

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Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury

1 reference

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Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

1 reference

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Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease

1 reference

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Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction

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1 reference

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1 reference

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Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

1 reference

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Astrocytic edema in CNS trauma

1 reference

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Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis

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Inflammation after trauma: microglial activation and traumatic brain injury

1 reference

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Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.

1 reference

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Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice

1 reference

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1 reference

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1 reference

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Essential protective roles of reactive astrocytes in traumatic brain injury

1 reference

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Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome

1 reference

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A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury

1 reference

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26 September 2018

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.

1 reference

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Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

1 reference

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26 September 2018

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation

1 reference

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26 September 2018

Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.

1 reference

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26 September 2018

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1 reference

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26 September 2018

Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging

1 reference

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Early detection of axonal injury after human head trauma using immunocytochemistry for beta-amyloid precursor protein

1 reference

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26 September 2018

Brain trauma in aged transgenic mice induces regression of established abeta deposits

1 reference

https://pubmed.ncbi.nlm.nih.gov/25904805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/25904805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Traumatic Brain Injury Exacerbates Neurodegenerative Pathology: Improvement with an Apolipoprotein E-Based Therapeutic

1 reference

https://pubmed.ncbi.nlm.nih.gov/25904805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytic swelling due to hypotonic or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release

1 reference

https://pubmed.ncbi.nlm.nih.gov/25904805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipocalin 2 Plays an Immunomodulatory Role and Has Detrimental Effects after Spinal Cord Injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/25904805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0291-15.2015

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25904805%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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