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Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
scientific article published on 24 May 2013
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Europe PubMed Central
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3706792
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23705774%20AND%20SRC:MED&resulttype=core&format=json
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1 March 2020
title
Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
(English)
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Europe PubMed Central
PMC publication ID
3706792
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1 March 2020
main subject
Alzheimer's disease
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author
Adam D Bachstetter
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2
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Europe PubMed Central
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3706792
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1 March 2020
Linda J Van Eldik
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3
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Linda J Van Eldik
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Europe PubMed Central
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3706792
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1 March 2020
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Scott J Webster
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1
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3706792
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publication date
24 May 2013
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1 March 2020
published in
Alzheimers Research & Therapy
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3706792
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23705774%20AND%20SRC:MED&resulttype=core&format=json
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1 March 2020
volume
5
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1 March 2020
issue
3
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3706792
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1 March 2020
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28
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1 March 2020
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27 June 2018
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
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27 June 2018
Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice.
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27 June 2018
Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease
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27 June 2018
Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
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27 June 2018
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
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27 June 2018
Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.
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27 June 2018
Regionally specific loss of neurons in the aging human hippocampus
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27 June 2018
Effects of group housing on stress induced emotional and neuroendocrine alterations
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4 September 2018
Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine
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4 September 2018
Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice.
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4 September 2018
Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD).
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4 September 2018
Novel object recognition as a facile behavior test for evaluating drug effects in AβPP/PS1 Alzheimer's disease mouse model.
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4 September 2018
Cognitive phenotyping of amyloid precursor protein transgenic J20 mice
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4 September 2018
When is the hippocampus involved in recognition memory?
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4 September 2018
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice.
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4 September 2018
Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.
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4 September 2018
Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.
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4 September 2018
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes
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4 September 2018
Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease.
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4 September 2018
Amyloid beta and impairment in multiple memory systems in older transgenic APP TgCRND8 mice
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4 September 2018
Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease
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4 September 2018
Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease
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4 September 2018
Limited impact of social isolation on Alzheimer-like symptoms in a triple transgenic mouse model
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4 September 2018
Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model
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4 September 2018
Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.
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4 September 2018
Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1δE9-deleted transgenic mice model of ß-amyloidosis
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4 September 2018
Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.
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4 September 2018
Effects of the genetic background on cognitive performances of TG2576 mice
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4 September 2018
Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice.
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4 September 2018
Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions.
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4 September 2018
Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom?
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4 September 2018
Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.
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4 September 2018
Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer's disease.
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4 September 2018
Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.
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4 September 2018
Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease.
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4 September 2018
The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys.
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4 September 2018
Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice
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4 September 2018
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
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4 September 2018
Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
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4 September 2018
Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.
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4 September 2018
Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze
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4 September 2018
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.
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4 September 2018
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
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4 September 2018
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
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4 September 2018
Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques
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4 September 2018
Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.
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4 September 2018
Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.
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4 September 2018
Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice.
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4 September 2018
Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease.
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4 September 2018
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
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4 September 2018
Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain
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4 September 2018
Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation
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4 September 2018
Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
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4 September 2018
Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation.
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4 September 2018
Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation
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4 September 2018
Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's disease
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4 September 2018
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.
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4 September 2018
Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice
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4 September 2018
Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain
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4 September 2018
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
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4 September 2018
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor
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4 September 2018
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
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4 September 2018
Performance of different mouse strains in an object recognition task
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4 September 2018
Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination
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4 September 2018
Age-dependent cognitive decline in the APP23 model precedes amyloid deposition
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4 September 2018
Progressive age-related impairment of cognitive behavior in APP23 transgenic mice
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4 September 2018
Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice
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4 September 2018
Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months.
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4 September 2018
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
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4 September 2018
Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
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4 September 2018
Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory.
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4 September 2018
Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation
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4 September 2018
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.
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4 September 2018
Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice
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4 September 2018
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.
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4 September 2018
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.
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4 September 2018
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
retrieved
4 September 2018
Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
retrieved
4 September 2018
Exposing rats to a predator impairs spatial working memory in the radial arm water maze.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
retrieved
4 September 2018
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
retrieved
4 September 2018
Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
retrieved
4 September 2018
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
retrieved
4 September 2018
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
retrieved
4 September 2018
Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706792
retrieved
4 September 2018
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1186%2FALZRT182
retrieved
21 January 2018
Transgenic mouse models of Alzheimer's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23705774
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23705774
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1186/ALZRT182
1 reference
stated in
Europe PubMed Central
PMC publication ID
3706792
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23705774%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
Dimensions Publication ID
1004886537
0 references
PMC publication ID
3706792
1 reference
stated in
Europe PubMed Central
PMC publication ID
3706792
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23705774%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
PubMed publication ID
23705774
1 reference
stated in
Europe PubMed Central
PMC publication ID
3706792
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23705774%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
ResearchGate publication ID
236936959
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