(Q36902298)

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Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches

scientific article published on January 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

17 August 2017

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Europe PubMed Central

Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

Daniel Watterson

5

object named as

D Martin Watterson

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Linda J Van Eldik

1

object named as

Linda J Van Eldik

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

author name string

Wendy L Thompson

2

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Hantamalala Ralay Ranaivo

3

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Heather A Behanna

4

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

publication date

1 January 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

International Review of Neurobiology

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

82

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

277-296

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines.

1 reference

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A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

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Predictive in silico modeling for hERG channel blockers

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Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers

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7 January 2021

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The many paths to p38 mitogen-activated protein kinase activation in the immune system

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Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs

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Gene-regulating protein kinases as important anti-inflammatory targets

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Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

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Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation

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Neuroinflammation: a potential therapeutic target

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Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid

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Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid

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Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration

1 reference

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7 January 2021

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p38 mitogen activated protein kinase as a therapeutic target for Alzheimer's disease

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Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases

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Pharmacophore modeling of cytochromes P450.

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The discovery of novel chemotypes of p38 kinase inhibitors

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A synthetic derivative of the natural product rocaglaol is a potent inhibitor of cytokine-mediated signaling and shows neuroprotective activity in vitro and in animal models of Parkinson's disease and traumatic brain injury

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Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice

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Novel anti-inflammatory therapy for Parkinson's disease.

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Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

1 reference

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Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development

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Defining the involvement of p38alpha MAPK in the production of anti- and proinflammatory cytokines using an SB 203580-resistant form of the kinase

1 reference

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p38 kinase is activated in the Alzheimer's disease brain

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The druggable genome

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Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model

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Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

1 reference

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Small molecule p38 inhibitors: novel structural features and advances from 2002-2005.

1 reference

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The p38 MAP kinase signaling pathway in Alzheimer's disease.

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MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits

1 reference

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Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production

1 reference

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Role of p38 and p44/42 mitogen-activated protein kinases in microglia

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p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

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Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

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Glia and their cytokines in progression of neurodegeneration

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1 reference

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1 reference

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1 reference

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1 reference

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7 January 2021

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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7 January 2021

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1 reference

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1 reference

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1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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Identifiers

10.1016/S0074-7742(07)82015-0

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

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