(Q36902298)

English

Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches

scientific article published on January 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

1 reference

Europe PubMed Central

Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

Daniel Watterson

5

object named as

D Martin Watterson

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Linda J Van Eldik

1

object named as

Linda J Van Eldik

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

author name string

Wendy L Thompson

2

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Hantamalala Ralay Ranaivo

3

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Heather A Behanna

4

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

publication date

1 January 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

International Review of Neurobiology

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

82

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

277-296

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Single-isomer drugs: true therapeutic advances

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Predictive in silico modeling for hERG channel blockers

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The many paths to p38 mitogen-activated protein kinase activation in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs

1 reference

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7 January 2021

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inferred from DOI database lookup

Gene-regulating protein kinases as important anti-inflammatory targets

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

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Hit and lead generation: beyond high-throughput screening

1 reference

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7 January 2021

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Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention

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7 January 2021

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inferred from DOI database lookup

Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroinflammation: a potential therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

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inferred from DOI database lookup

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

p38 mitogen activated protein kinase as a therapeutic target for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacophore modeling of cytochromes P450.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The discovery of novel chemotypes of p38 kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A synthetic derivative of the natural product rocaglaol is a potent inhibitor of cytokine-mediated signaling and shows neuroprotective activity in vitro and in animal models of Parkinson's disease and traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel anti-inflammatory therapy for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Defining the involvement of p38alpha MAPK in the production of anti- and proinflammatory cytokines using an SB 203580-resistant form of the kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

p38 kinase is activated in the Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The druggable genome

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Small molecule p38 inhibitors: novel structural features and advances from 2002-2005.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The p38 MAP kinase signaling pathway in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of p38 and p44/42 mitogen-activated protein kinases in microglia

1 reference

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7 January 2021

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inferred from DOI database lookup

Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation

1 reference

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7 January 2021

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inferred from DOI database lookup

Can the pharmaceutical industry reduce attrition rates?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alpha protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

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Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities

1 reference

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7 January 2021

based on heuristic

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Compound lipophilicity for substrate binding to human P450s in drug metabolism

1 reference

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7 January 2021

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

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7 January 2021

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ElogPoct: a tool for lipophilicity determination in drug discovery

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyridazine based inhibitors of p38 MAPK.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Glia and their cytokines in progression of neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

p38 MAP kinase inhibitors. Part 6: 2-arylpyridazin-3-ones as templates for inhibitor design

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

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Targeting signal transduction as a strategy to treat inflammatory diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

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Anti-TNF-alpha therapies: the next generation

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Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Alzheimer's disease and Parkinson's disease: distinct entities or extremes of a spectrum of neurodegeneration?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurodegenerative disease and the neuroimmune axis (Alzheimer's and Parkinson's disease, and viral infections).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

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based on heuristic

inferred from DOI database lookup

The druggable genome: an update

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The p38 MAP kinase pathway as a therapeutic target in inflammatory disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Research & market strategy: how choice of drug discovery approach can affect market position

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The biology of p38 kinase: a central role in inflammation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Microglia and neuroinflammation: a pathological perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

P38 MAP kinase is activated at early stages in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of inflammation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

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inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural comparison of p38 inhibitor-protein complexes: a review of recent p38 inhibitors having unique binding interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2982015-0

7 January 2021

based on heuristic

inferred from DOI database lookup

P38 activation mediates amyloid-beta cytotoxicity

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0074-7742(07)82015-0

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

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