(Q35577256)

9 August 2017

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title

The "fuzzy logic" of the death-inducing signaling complex in lymphocytes (English)

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9 August 2017

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Craig M Walsh

1

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9 August 2017

Keith A Luhrs

series ordinal

2

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9 August 2017

Adrian F Arechiga

series ordinal

3

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9 August 2017

language of work or name

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1 September 2003

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Journal of Clinical Immunology

9 August 2017

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9 August 2017

23

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9 August 2017

5

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9 August 2017

333-353

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https://scigraph.springernature.com/pub.10.1023/a:1025313415487

9 August 2017

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cites work

Programmed cell death in Caenorhabditis elegans

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12 December 2020

Immunological adjuvants promote activated T cell survival via induction of Bcl-3.

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12 December 2020

Mechanisms of lymphocyte-mediated cytotoxicity. I. The effects of anti-human lymphotoxin antisera on the cytolysis of allogeneic B cell lines by MLC-sensitized human lymphocytes in vitro

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12 December 2020

Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways

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12 December 2020

Apoptotic and necrotic cell death induced by death domain receptors.

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12 December 2020

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression

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12 December 2020

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

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12 December 2020

Inhibition of death receptor signals by cellular FLIP

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12 December 2020

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

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12 December 2020

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.

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12 December 2020

TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator

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12 December 2020

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

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12 December 2020

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

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12 December 2020

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

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12 December 2020

Synthetic activation of caspases: artificial death switches

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12 December 2020

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

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12 December 2020

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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12 December 2020

Molecular pathways of CTL-mediated cytotoxicity

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12 December 2020

A dominant negative Fas-associated death domain protein mutant inhibits proliferation and leads to impaired calcium mobilization in both T-cells and fibroblasts

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12 December 2020

Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment

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12 December 2020

A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis

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12 December 2020

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

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12 December 2020

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

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12 December 2020

The requirements for Fas-associated death domain signaling in mature T cell activation and survival

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12 December 2020

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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12 December 2020

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

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12 December 2020

The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice.

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12 December 2020

Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms

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12 December 2020

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice

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12 December 2020

Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils

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12 December 2020

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

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12 December 2020

Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

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12 December 2020

Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress

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12 December 2020

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

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12 December 2020

The CD95(APO-1/Fas) DISC and beyond

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12 December 2020

Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.

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12 December 2020

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

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12 December 2020

Analysis of the CD95 (APO-1/Fas) death-inducing signaling complex by high-resolution two-dimensional gel electrophoresis

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12 December 2020

Caspase activation: the induced-proximity model

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12 December 2020

Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.

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12 December 2020

A role for FADD in T cell activation and development

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12 December 2020

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.

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12 December 2020

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

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12 December 2020

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

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12 December 2020

Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I.

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12 December 2020

Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10.

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12 December 2020

The CARD domain: a new apoptotic signalling motif

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12 December 2020

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

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12 December 2020

Caspases: enemies within

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12 December 2020

Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

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12 December 2020

The suicide in the thymus, a twisted trail

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12 December 2020

A role for perforin in activation-induced T cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID mice

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12 December 2020

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

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12 December 2020

Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis

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12 December 2020

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

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12 December 2020

Cutting edge: antigen-independent CD8 T cell proliferation.

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12 December 2020

The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

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12 December 2020

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

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12 December 2020

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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12 December 2020

A Function of Fas-Associated Death Domain Protein in Cell Cycle Progression Localized to a Single Amino Acid at Its C-Terminal Region

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12 December 2020

Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis

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12 December 2020

Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis

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12 December 2020

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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12 December 2020

The role of c-FLIP in modulation of CD95-induced apoptosis

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12 December 2020

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

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12 December 2020

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse

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12 December 2020

Positive and negative selection of T cells

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12 December 2020

A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans.

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12 December 2020

NADH oxidase activity of mitochondrial apoptosis-inducing factor

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12 December 2020

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

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12 December 2020

p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice

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12 December 2020

Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells

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12 December 2020

Induction of apoptosis in mature T cells by tumour necrosis factor

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12 December 2020

TNFalpha-induced IEC-6 cell apoptosis requires activation of ICE caspases whereas complete inhibition of the caspase cascade leads to necrotic cell death

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12 December 2020

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

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12 December 2020

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

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12 December 2020

Structural basis of caspase-7 inhibition by XIAP

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12 December 2020

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

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12 December 2020

Fas modulation of apoptosis during negative selection of thymocytes

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12 December 2020

Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

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12 December 2020

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

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12 December 2020

Regulation of lymphocyte proliferation and death by FLIP.

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12 December 2020

Deficiency of the Fas apoptosis pathway without Fas gene mutations in pediatric patients with autoimmunity/lymphoproliferation.

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12 December 2020

IAP family proteins--suppressors of apoptosis

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12 December 2020

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

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12 December 2020

Monoclonal antibody-mediated tumor regression by induction of apoptosis.

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12 December 2020

A cellular calculus for signal integration by T cells

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12 December 2020

Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans

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12 December 2020

Structural basis for the inhibition of caspase-3 by XIAP

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12 December 2020

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

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12 December 2020

Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells.

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12 December 2020

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis

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12 December 2020

Mechanisms of lymphocyte-mediated cytotoxicity. II. biochemical and serologic identification of a precursor lymphotoxin form (pre-LT) produced by MLC-sensitized human T lymphocytes in vitro

1 reference

12 December 2020

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1 reference

12 December 2020

Mechanisms of lymphocyte-mediated cytotoxicity. III. Characterization of the mechanism of inhibition of the human alloimmune lymphocyte-mediated cytotoxic reaction by polyspecific anti-lymphotoxin sera in vitro

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12 December 2020

Sensitization to death receptor cytotoxicity by inhibition of fas-associated death domain protein (FADD)/caspase signaling. Requirement of cell cycle progression

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12 December 2020

Human ICE/CED-3 protease nomenclature

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12 December 2020

MHC and T cell development

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12 December 2020

Caspase-independent cell killing by Fas-associated protein with death domain

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12 December 2020

Fas transduces activation signals in normal human T lymphocytes

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12 December 2020

The regulation of self-reactive B cells.

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12 December 2020

Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency

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12 December 2020

Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2.

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12 December 2020

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

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12 December 2020

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

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12 December 2020

Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice

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12 December 2020

An induced proximity model for caspase-8 activation.

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12 December 2020

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

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12 December 2020

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

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12 December 2020

Characterization of XIAP-deficient mice

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12 December 2020

Caspase activation is required for T cell proliferation

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12 December 2020

Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes

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12 December 2020

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

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12 December 2020

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

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12 December 2020

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

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12 December 2020

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

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12 December 2020

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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12 December 2020

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

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12 December 2020

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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12 December 2020

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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12 December 2020

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

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12 December 2020

Antiapoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families

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12 December 2020

Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice

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12 December 2020

RAIDD is a new 'death' adaptor molecule

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12 December 2020

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

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12 December 2020

T cell-specific FADD-deficient mice: FADD is required for early T cell development

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12 December 2020

Apoptosis control by death and decoy receptors

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12 December 2020

A decision between life and death during TNF-alpha-induced signaling

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12 December 2020

Molecular cloning of the interleukin-1 beta converting enzyme

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12 December 2020

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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12 December 2020

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12 December 2020

Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.

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12 December 2020

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation

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12 December 2020

Caspase enzyme activity is not essential for apoptosis during thymocyte development

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12 December 2020

I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis

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12 December 2020

Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity

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12 December 2020

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules

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12 December 2020

Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

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12 December 2020

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

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12 December 2020

FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation

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12 December 2020

MAP kinases in the immune response

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12 December 2020

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

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12 December 2020

An endotoxin-induced serum factor that causes necrosis of tumors

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12 December 2020

Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis

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12 December 2020

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

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12 December 2020

Role of inherited defects decreasing Fas function in autoimmunity.

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12 December 2020

Genetic control of programmed cell death in the nematode C. elegans.

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12 December 2020

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

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12 December 2020

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

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12 December 2020

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

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12 December 2020

Apoptosis-independent functions of killer caspases.

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12 December 2020

DR3 regulates negative selection during thymocyte development

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12 December 2020

Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

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12 December 2020

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

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12 December 2020

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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12 December 2020

Phosphorylation of FADD/MORT1 and Fas by kinases that associate with the membrane-proximal cytoplasmic domain of Fas

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12 December 2020

Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor

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12 December 2020

Caspase-10 is an initiator caspase in death receptor signaling

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12 December 2020

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

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12 December 2020

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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12 December 2020

Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP

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12 December 2020

In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes

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12 December 2020

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

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12 December 2020

Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6

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12 December 2020

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

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12 December 2020

FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery

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12 December 2020

A role for a pre-T-cell receptor in T-cell development

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12 December 2020

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

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12 December 2020

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

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12 December 2020

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

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12 December 2020

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

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12 December 2020

T-cell apoptosis detected in situ during positive and negative selection in the thymus

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12 December 2020

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

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12 December 2020

Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death

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12 December 2020

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

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12 December 2020

Pro-caspase-3 is a major physiologic target of caspase-8.

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12 December 2020

Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes

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12 December 2020

Lymphocyte in vitro cytotoxicity: characterization of human lymphotoxin

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12 December 2020

X-linked IAP is a direct inhibitor of cell-death proteases

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12 December 2020

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

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12 December 2020

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

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12 December 2020

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

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12 December 2020

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

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12 December 2020

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

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12 December 2020

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

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12 December 2020

Signal transduction by tumor necrosis factor and its relatives

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12 December 2020

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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12 December 2020

The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death

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12 December 2020

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

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12 December 2020

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

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12 December 2020

Apo2L/TRAIL and its death and decoy receptors

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12 December 2020

Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase

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12 December 2020

Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells

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12 December 2020

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death

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12 December 2020

Structural Basis of Caspase Inhibition by XIAP

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12 December 2020

Identifiers

DOI

10.1023/A:1025313415487

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Dimensions Publication ID

9 August 2017

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