(Q35590750)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

9

1 reference

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4 March 2020

author name string

Chris R Evelyn

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Jacek Biesiada

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Xin Duan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Hong Tang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Xun Shang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Ruben Papoian

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

William L Seibel

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Sandra Nelson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Yi Zheng

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

language of work or name

English

0 references

publication date

30 March 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

4 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

volume

290

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

issue

20

1 reference

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4 March 2020

page(s)

12879-12898

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.

4 March 2020

cites work

1 reference

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Chemistry: Chemical con artists foil drug discovery

27 July 2018

1 reference

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Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response

27 July 2018

1 reference

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Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists

27 July 2018

1 reference

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Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

27 July 2018

1 reference

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

27 July 2018

1 reference

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Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

27 July 2018

1 reference

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Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting

27 July 2018

1 reference

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

RAS oncogenes: weaving a tumorigenic web

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Molecular interaction studies using microscale thermophoresis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Identification of differentially expressed genes in breast tumors from African American compared with Caucasian women

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Protein-binding assays in biological liquids using microscale thermophoresis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

POLYVIEW-MM: web-based platform for animation and analysis of molecular simulations.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Many faces of Ras activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Development of farnesyl transferase inhibitors: a review

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Structural analysis of autoinhibition in the Ras activator Son of sevenless

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

27 July 2018

RHO-GTPases and cancer

1 reference

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The structural basis of the activation of Ras by Sos

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Identification of Ras farnesyltransferase inhibitors by microbial screening

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Small-molecule modulation of Ras signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

ProBiS-2012: web server and web services for detection of structurally similar binding sites in proteins

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Survey of public domain software for docking simulations and virtual screening.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Understanding SOS (Son of Sevenless).

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

An orthosteric inhibitor of the Ras-Sos interaction

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Ras history: The saga continues

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Fluorescence approaches to study G protein mechanisms.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Dbl family guanine nucleotide exchange factors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432303

Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25825487

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25825487

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutational analysis of SOS1 gene in acute myeloid leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25825487

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.634493

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825487%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

PubMed publication ID

25825487

1 reference