(Q37304601)

English

Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation

scientific article published on July 2009

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scholarly article

1 reference

Europe PubMed Central

19 August 2017

Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation (English)

1 reference

Europe PubMed Central

19 August 2017

virtual screening

1 reference

based on heuristic

inferred from title

quantitative structure-activity relationship

1 reference

based on heuristic

inferred from title

Alexander Tropsha

4

object named as

Alexander Tropsha

1 reference

Europe PubMed Central

19 August 2017

author name string

Yuri K Peterson

1

1 reference

Europe PubMed Central

19 August 2017

Xiang S Wang

2

1 reference

Europe PubMed Central

19 August 2017

Patrick J Casey

3

1 reference

Europe PubMed Central

19 August 2017

language of work or name

0 references

publication date

1 July 2009

1 reference

Europe PubMed Central

19 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

19 August 2017

52

1 reference

Europe PubMed Central

19 August 2017

14

1 reference

Europe PubMed Central

19 August 2017

4210-4220

1 reference

Europe PubMed Central

19 August 2017

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1 reference

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Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds

1 reference

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1 reference

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1 reference

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1 reference

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Farnesyltransferase inhibitors: promises and realities

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1 reference

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Protein prenylation: molecular mechanisms and functional consequences

1 reference

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Protein prenyltransferases

1 reference

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cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I

1 reference

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Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I

1 reference

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Small-molecule inhibitors of protein geranylgeranyltransferase type I.

1 reference

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A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity

1 reference

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Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

1 reference

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The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity

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The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

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Development of inhibitors of protein farnesylation as potential chemotherapeutic agents.

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Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

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Broad-based quantitative structure-activity relationship modeling of potency and selectivity of farnesyltransferase inhibitors using a Bayesian regularized neural network

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Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics

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Identifiers

10.1021/JM8013772

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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