(Q35188280)

7 August 2017

title

Small-molecule modulation of Ras signaling (English)

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7 August 2017

5

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7 August 2017

Philipp M Cromm

2

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Jochen Spiegel

object named as

Jochen Spiegel

series ordinal

1

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Tom N Grossmann

object named as

Tom N Grossmann

series ordinal

4

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author name string

Gunther Zimmermann

series ordinal

3

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7 August 2017

publication date

15 June 2014

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7 August 2017

published in

Nature Chemical Biology

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7 August 2017

volume

10

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7 August 2017

issue

8

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7 August 2017

page(s)

613-622

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Interaction of a novel GDP exchange inhibitor with the Ras protein

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Design, synthesis and biological evaluation of sugar-derived Ras inhibitors

21 January 2018

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An orthosteric inhibitor of the Ras-Sos interaction

21 January 2018

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Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells.

21 January 2018

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Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins

21 January 2018

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Novel allosteric sites on Ras for lead generation

21 January 2018

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Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

21 January 2018

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A decade of fragment-based drug design: strategic advances and lessons learned

21 January 2018

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

21 January 2018

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

21 January 2018

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Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists

21 January 2018

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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

21 January 2018

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Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor

21 January 2018

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

21 January 2018

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Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

21 January 2018

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

21 January 2018

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Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy

21 January 2018

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Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics

21 January 2018

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Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

21 January 2018

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Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Interfering with RAS–effector protein interactions prevent RAS-dependent tumour initiation and causes stop–start control of cancer growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

In vitro inhibition of Ras-Raf association by short peptides

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Inhibition of Ras-Effector Interaction by Cyclic Peptides

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Sulindac sulfide inhibits Ras signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: implications for the mechanism of iron-sulfur cluster assembly

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors

21 January 2018

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

21 January 2018

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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

21 January 2018

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Regulating the regulator: post-translational modification of RAS

21 January 2018

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

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Endocrine therapy plus zoledronic acid in premenopausal breast cancer.

21 January 2018

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Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery

21 January 2018

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Amino Derivatives of Indole As Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase

21 January 2018

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Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.

21 January 2018

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A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations

21 January 2018

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Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Small-molecule inhibition of APT1 affects Ras localization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

The prenyl-binding protein PrBP/δ: a chaperone participating in intracellular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Dragging ras back in the ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Small-molecule discovery from DNA-encoded chemical libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

A highly flexible tRNA acylation method for non-natural polypeptide synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Translation initiation with initiator tRNA charged with exotic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Direct targeting of Rab-GTPase-effector interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Guanosine triphosphatase stimulation of oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

'Pathway drug cocktail': targeting Ras signaling based on structural pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Mutant and wild-type Ras: co-conspirators in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1560

Post-prenylation-processing enzymes as new targets in oncogenesis

21 January 2018

1 reference

12 December 2020

Metal-bis(2-picolyl)amine complexes as state 1(T) inhibitors of activated Ras protein

1 reference

12 December 2020

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

1 reference

12 December 2020

Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation

1 reference

12 December 2020

Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I

1 reference

12 December 2020

Ras-mediated cleavage of a GTP analogue by a novel mechanism

1 reference

12 December 2020

Hydrocarbon-stapled peptides: principles, practice, and progress

1 reference

12 December 2020

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

1 reference

12 December 2020

Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras

1 reference

12 December 2020

KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport

1 reference

12 December 2020

A novel mechanism for the modulation of the Ras-effector interaction by small molecules

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1560

1 reference

Dimensions Publication ID

7 August 2017

1033601350

0 references

1 reference