(Q35730802)

9 August 2017

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title

Feedback regulation of lymphocyte signalling (English)

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9 August 2017

2

Tilman Brummer

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author name string

Michael Reth

series ordinal

1

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9 August 2017

1 April 2004

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Nature Reviews Immunology

9 August 2017

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9 August 2017

4

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9 August 2017

269-277

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9 August 2017

4

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MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity

9 August 2017

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Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2

21 January 2018

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Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes

21 January 2018

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Insulin-stimulated disassociation of the SOS-Grb2 complex

21 January 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Regulation of RasGRP via a phorbol ester-responsive C1 domain.

21 January 2018

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Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells

21 January 2018

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Genetic analysis of B cell antigen receptor signaling

21 January 2018

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

31 March 2020

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Duration of calcineurin and Erk signals regulates CD4/CD8 lineage commitment of thymocytes

31 March 2020

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The influence of the MAPK pathway on T cell lineage commitment

31 March 2020

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Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

31 March 2020

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Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

31 March 2020

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Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

31 March 2020

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BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.

31 March 2020

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PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.

31 March 2020

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The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

31 March 2020

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Initiation and processing of signals from the B cell antigen receptor

31 March 2020

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Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability

31 March 2020

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Signaling through scaffold, anchoring, and adaptor proteins

31 March 2020

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Adaptors as central mediators of signal transduction in immune cells

31 March 2020

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Signal transduction. Autoinhibition control

31 March 2020

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Variation on an Src-like theme

31 March 2020

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Crystal structure of the tyrosine phosphatase SHP-2

31 March 2020

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

31 March 2020

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Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22

31 March 2020

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

31 March 2020

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Role of Syk in B-cell development and antigen-receptor signaling

31 March 2020

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Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

31 March 2020

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Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130

31 March 2020

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Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

31 March 2020

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Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase

31 March 2020

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Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor

31 March 2020

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Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

31 March 2020

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Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail

31 March 2020

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Increasing complexity of Ras signaling.

31 March 2020

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Ras proteins: different signals from different locations

31 March 2020

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Distinct requirements for Ras oncogenesis in human versus mouse cells

31 March 2020

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Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes

31 March 2020

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To make antibodies or not: signaling by the B-cell antigen receptor

31 March 2020

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The Ras/MAPK cascade and the control of positive selection

31 March 2020

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

31 March 2020

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RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

31 March 2020

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Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling

31 March 2020

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

31 March 2020

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Xid-like phenotypes: a B cell signalosome takes shape

31 March 2020

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31 March 2020

Amplifying Btk's Signal

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Positive versus negative signaling by lymphocyte antigen receptors

31 March 2020

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SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma

31 March 2020

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Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

31 March 2020

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Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

31 March 2020

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Hyperresponsive B cells in CD22-deficient mice

31 March 2020

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CD22 is a negative regulator of B-cell receptor signalling

31 March 2020

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PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization

31 March 2020

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The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction

31 March 2020

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Activation of T cells via tumor antigen specific chimeric receptors: the role of the intracellular signaling domain

31 March 2020

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In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1

31 March 2020

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NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta

31 March 2020

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The "Gab" in signal transduction.

31 March 2020

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Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention

31 March 2020

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Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors

31 March 2020

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Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

31 March 2020

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Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway

31 March 2020

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The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

31 March 2020

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Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis

31 March 2020

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Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

31 March 2020

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KSR is a scaffold required for activation of the ERK/MAPK module

31 March 2020

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

31 March 2020

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Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation

31 March 2020

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Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

31 March 2020

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Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex

31 March 2020

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EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2

31 March 2020

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

31 March 2020

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Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation

31 March 2020

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Suppressors of cytokine signalling (SOCS) in the immune system

31 March 2020

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The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

31 March 2020

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Immune inhibitory receptors

31 March 2020

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Hydrogen peroxide as second messenger in lymphocyte activation

31 March 2020

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Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain

31 March 2020

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Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck

31 March 2020

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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

31 March 2020

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Transcriptional control of B-cell development

31 March 2020

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Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

31 March 2020

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Transcriptional regulatory cascades controlling plasma cell differentiation

31 March 2020

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BCL-6 is phosphorylated at multiple sites in its serine- and proline-clustered region by mitogen-activated protein kinase (MAPK) in vivo

31 March 2020

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Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

31 March 2020

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Plasma cells: finding new light at the end of B cell development

31 March 2020

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Negative regulation of TCR signaling and T-cell activation by selective protein degradation

31 March 2020

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Cbl: many adaptations to regulate protein tyrosine kinases

31 March 2020

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

31 March 2020

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LAT links the pre-BCR to calcium signaling

31 March 2020

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The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival

31 March 2020

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Bam32 Links the B Cell Receptor to ERK and JNK and Mediates B Cell Proliferation but Not Survival

31 March 2020

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Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

31 March 2020

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SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates

31 March 2020

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Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling

31 March 2020

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Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

31 March 2020

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A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1335

1 reference

9 August 2017

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PubMed ID

15057785