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HIV-1 antiretroviral drug therapy
scientific article published in April 2012
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
title
HIV-1 antiretroviral drug therapy
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
main subject
anti-retroviral agent
0 references
author name string
Eric J Arts
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
Daria J Hazuda
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
publication date
1 April 2012
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
published in
Cold Spring Harbor Perspectives in Medicine
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
volume
2
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
issue
4
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
page(s)
a007161
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stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
cites work
HIV-1 reverse transcription
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11 July 2018
HIV: cell binding and entry
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11 July 2018
HIV-1 assembly, budding, and maturation
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11 July 2018
HIV DNA integration
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11 July 2018
HIV Restriction Factors and Mechanisms of Evasion
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11 July 2018
Transcriptional and posttranscriptional regulation of HIV-1 gene expression
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A Guide to HIV-1 Reverse Transcriptase and Protease Sequencing for Drug Resistance Studies
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Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA
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11 July 2018
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
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11 July 2018
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
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11 July 2018
Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication
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11 July 2018
Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors.
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11 July 2018
Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design
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11 July 2018
Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome
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11 July 2018
Integrase variability and susceptibility to HIV integrase inhibitors: impact of subtypes, antiretroviral experience and duration of HIV infection.
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11 July 2018
Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120
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11 July 2018
Strand transfer inhibitors of HIV-1 integrase: bringing IN a new era of antiretroviral therapy
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11 July 2018
Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways
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11 July 2018
Selective-advantage profile of human immunodeficiency virus type 1 integrase mutants explains in vivo evolution of raltegravir resistance genotypes.
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11 July 2018
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein
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11 July 2018
Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors
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11 July 2018
Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants
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11 July 2018
In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject
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11 July 2018
Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists
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11 July 2018
Viral drug resistance and fitness.
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11 July 2018
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
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11 July 2018
Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection
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11 July 2018
Natural variation in the V3 crown of human immunodeficiency virus type 1 affects replicative fitness and entry inhibitor sensitivity
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11 July 2018
Structural definition of a conserved neutralization epitope on HIV-1 gp120
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11 July 2018
Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
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11 July 2018
The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations
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11 July 2018
Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
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11 July 2018
The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.
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11 July 2018
Functional impact of HIV coreceptor-binding site mutations
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11 July 2018
Virus fitness: concept, quantification, and application to HIV population dynamics.
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11 July 2018
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
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11 July 2018
Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
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11 July 2018
Fusion of HIV-1 envelope-expressing cells to human glomerular endothelial cells through an CXCR4-mediated mechanism
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11 July 2018
Antiretroviral compounds: mechanisms underlying failure of HAART to eradicate HIV-1.
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11 July 2018
Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry
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11 July 2018
Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization
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11 July 2018
Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding
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Emergence of a drug-dependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor.
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11 July 2018
Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.
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11 July 2018
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
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11 July 2018
Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity
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11 July 2018
Characterization of a subtype D human immunodeficiency virus type 1 isolate that was obtained from an untreated individual and that is highly resistant to nonnucleoside reverse transcriptase inhibitors
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11 July 2018
Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor
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11 July 2018
Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.
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11 July 2018
PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing
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11 July 2018
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding
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11 July 2018
Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication
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11 July 2018
A novel genetic pathway of human immunodeficiency virus type 1 resistance to stavudine mediated by the K65R mutation
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11 July 2018
Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.
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11 July 2018
Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
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11 July 2018
Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance
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11 July 2018
Fitness of drug resistant HIV-1: methodology and clinical implications
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11 July 2018
Baseline susceptibility of primary human immunodeficiency virus type 1 to entry inhibitors
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11 July 2018
Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
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11 July 2018
Mutational analysis of HIV-1 long terminal repeats to explore the relative contribution of reverse transcriptase and RNA polymerase II to viral mutagenesis
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11 July 2018
ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase
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11 July 2018
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.
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11 July 2018
Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes
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11 July 2018
Implications of antiretroviral resistance on viral fitness
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11 July 2018
Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase
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11 July 2018
HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use
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11 July 2018
Impact of clinical reverse transcriptase sequences on the replication capacity of HIV-1 drug-resistant mutants
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11 July 2018
Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy
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PubMed Central
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11 July 2018
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
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11 July 2018
HIV chemotherapy
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11 July 2018
International perspectives on antiretroviral resistance. Resistance to protease inhibitors
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11 July 2018
International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance
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11 July 2018
Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles
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11 July 2018
Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion
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11 July 2018
Strong in vitro synergy between the fusion inhibitor T-20 and the CXCR4 blocker AMD-3100.
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11 July 2018
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
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11 July 2018
HIV drug resistance and viral fitness.
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11 July 2018
Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120
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11 July 2018
Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy
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11 July 2018
A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5
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11 July 2018
Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs
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11 July 2018
Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260)
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11 July 2018
HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness
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11 July 2018
Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV
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11 July 2018
A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
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11 July 2018
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
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11 July 2018
Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
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11 July 2018
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance
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11 July 2018
Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry
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11 July 2018
Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases
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11 July 2018
Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients
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11 July 2018
Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides
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11 July 2018
Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: results of AIDS Clinical Trials Group Protocol 315.
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11 July 2018
Novel Gag-Pol frameshift site in human immunodeficiency virus type 1 variants resistant to protease inhibitors
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11 July 2018
Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo.
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11 July 2018
Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides.
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11 July 2018
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
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11 July 2018
Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites
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11 July 2018
An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication
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11 July 2018
Anti-viral drug treatment: dynamics of resistance in free virus and infected cell populations
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11 July 2018
Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.
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11 July 2018
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms
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11 July 2018
Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1
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11 July 2018
Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility
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11 July 2018
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
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11 July 2018
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
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11 July 2018
Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.
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11 July 2018
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
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11 July 2018
Identification of a major co-receptor for primary isolates of HIV-1
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11 July 2018
Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
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11 July 2018
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
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11 July 2018
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time
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11 July 2018
Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group
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11 July 2018
A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3312400
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11 July 2018
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids
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11 July 2018
Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection
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11 July 2018
The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter
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11 July 2018
HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy
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11 July 2018
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
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11 July 2018
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
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11 July 2018
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides
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11 July 2018
Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
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11 July 2018
Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase
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11 July 2018
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.
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11 July 2018
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1
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11 July 2018
Viral dynamics in human immunodeficiency virus type 1 infection
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11 July 2018
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance
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11 July 2018
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
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11 July 2018
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
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11 July 2018
Therapeutic efficacy of amantadine HCl and rimantadine HCl in naturally occurring influenza A2 respiratory illness in man.
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11 July 2018
The molecular basis of the specific anti-influenza action of amantadine
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11 July 2018
The role of the FDA in the effort against AIDS
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11 July 2018
Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides
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11 July 2018
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds
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11 July 2018
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
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11 July 2018
3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase
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11 July 2018
Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs
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11 July 2018
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
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11 July 2018
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
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11 July 2018
Inhibition of HIV replication in acute and chronic infections in vitro by a Tat antagonist
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11 July 2018
Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma
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11 July 2018
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
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11 July 2018
Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
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11 July 2018
Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects
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11 July 2018
Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility
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24 September 2018
Mutation and control of the human immunodeficiency virus
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24 September 2018
Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652.
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24 September 2018
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion
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24 September 2018
Structural analysis of reverse transcriptase mutations at codon 215 explains the predominance of T215Y over T215F in HIV-1 variants selected under antiretroviral therapy
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24 September 2018
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
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24 September 2018
Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1.
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24 September 2018
Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure
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24 September 2018
Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations
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24 September 2018
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24 September 2018
A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors
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24 September 2018
Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure
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24 September 2018
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24 September 2018
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24 September 2018
Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir
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24 September 2018
Virological and immunological analysis of a triple combination pilot study with loviride, lamivudine and zidovudine in HIV-1-infected patients.
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Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group P
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24 September 2018
Mutations in the protease gene of human immunodeficiency virus type 1 affect release and stability of virus particles
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24 September 2018
Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection.
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24 September 2018
Virological and immunological response to HAART regimen containing integrase inhibitors in HIV-2-infected patients
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6 December 2018
Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
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A humanized form of a CD4-specific monoclonal antibody exhibits decreased antigenicity and prolonged plasma half-life in rhesus monkeys while retaining its unique biological and antiviral properties
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based on heuristic
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Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1
1 reference
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12 December 2020
based on heuristic
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Identifiers
DOI
10.1101/CSHPERSPECT.A007161
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
PMCID
3312400
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
PubMed ID
22474613
1 reference
stated in
Europe PubMed Central
PMCID
3312400
retrieved
10 August 2017
ResearchGate publication ID
223987068
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