(Q35895097)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15383309%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

review article

1 reference

title

From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15383309%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

João Pedro de Magalhães

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15383309%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

João Pedro de Magalhães

series ordinal

1

object named as

João Pedro de Magalhães

1 reference

11 August 2017

language of work or name

English

0 references

publication date

1 October 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15383309%20AND%20SRC:MED&resulttype=core&format=json

Experimental Cell Research

1 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15383309%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

300

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15383309%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15383309%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

page(s)

1-10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15383309%20AND%20SRC:MED&resulttype=core&format=json

From cells to organisms: can we learn about aging from cells in culture?

1 January 2020

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Stress-induced premature senescence or stress-induced senescence-like phenotype: one in vivo reality, two possible definitions?

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Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells

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Replicative senescence of human fibroblast-like cells in culture

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Human skin fibroblasts in vitro differentiate along a terminal cell lineage

7 January 2021

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Telomeres shorten during ageing of human fibroblasts

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Extension of life-span by introduction of telomerase into normal human cells

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Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

7 January 2021

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Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model.

7 January 2021

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Telomere maintenance mechanisms and cellular immortalization.

7 January 2021

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Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

7 January 2021

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A mutant with a defect in telomere elongation leads to senescence in yeast

7 January 2021

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Cellular senescence as a tumor-protection mechanism: the essential role of counting

7 January 2021

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

7 January 2021

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Association of human papillomavirus types 16 and 18 E6 proteins with p53.

7 January 2021

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Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

7 January 2021

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The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis

7 January 2021

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Retinoblastoma protein switches the E2F site from positive to negative element

7 January 2021

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Cyclin dependent kinase regulation

7 January 2021

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

7 January 2021

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

7 January 2021

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

7 January 2021

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Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

7 January 2021

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Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

7 January 2021

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7 January 2021

p53: puzzle and paradigm

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WAF1, a potential mediator of p53 tumor suppression

7 January 2021

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From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging

7 January 2021

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Putting the stress on senescence

7 January 2021

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A DNA damage checkpoint response in telomere-initiated senescence

7 January 2021

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Critical assessment of paradigms in aging research

7 January 2021

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The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives

7 January 2021

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

7 January 2021

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Molecular changes in cell surface membranes resulting from trypsinization of sarcoma 180 tumor cells

7 January 2021

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Depletion of cellular glutathione by conditions used for the passaging of adherent cultured cells

7 January 2021

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Taking cell-matrix adhesions to the third dimension

7 January 2021

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Taking the study of cancer cell survival to a new dimension

7 January 2021

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Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity

7 January 2021

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Telomere-driven replicative senescence is a stress response

7 January 2021

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Oxidative DNA damage and senescence of human diploid fibroblast cells.

7 January 2021

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Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

7 January 2021

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7 January 2021

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Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

7 January 2021

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Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts

7 January 2021

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Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence

7 January 2021

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Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

7 January 2021

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Cellular response to oxidative stress: signaling for suicide and survival

7 January 2021

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

7 January 2021

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

7 January 2021

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BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection.

7 January 2021

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Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts

7 January 2021

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

7 January 2021

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

7 January 2021

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A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status

7 January 2021

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Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

7 January 2021

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Aging alters the apoptotic response to genotoxic stress

7 January 2021

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Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians.

7 January 2021

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The relationship between in vitro cellular aging and in vivo human age

7 January 2021

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Growth Properties and Growth Factor Responsiveness in Skin Fibroblasts from Centenarians

7 January 2021

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Insights on immunological aging derived from the T lymphocyte cellular senescence model

7 January 2021

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Can we say that senescent cells cause ageing?

7 January 2021

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Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes

7 January 2021

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The role of stem cells in aging

7 January 2021

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Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age

7 January 2021

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The impact of donor age on liver transplantation: influence of donor age on early liver function and on subsequent patient and graft survival.

7 January 2021

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Outcomes in cardiac transplant recipients using allografts from older donors versus mortality on the transplant waiting list; Implications for donor selection criteria.

7 January 2021

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No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2.

7 January 2021

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Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis

7 January 2021

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Spontaneous and induced chromosomal instability in Werner syndrome

7 January 2021

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Fibroblasts cultured from venous ulcers display cellular characteristics of senescence

7 January 2021

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Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

7 January 2021

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Cellular senescence in the pathogenesis of benign prostatic hyperplasia

7 January 2021

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The role of chondrocyte senescence in osteoarthritis

7 January 2021

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Association between telomere length in blood and mortality in people aged 60 years or older

7 January 2021

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Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation

7 January 2021

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Telomere Length in Fibroblasts and Blood Cells from Healthy Centenarians

7 January 2021

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Is beta-galactosidase staining a marker of senescence in vitro and in vivo?

7 January 2021

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Role of the INK4a locus in tumor suppression and cell mortality.

7 January 2021

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The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes

7 January 2021

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Immortalization of Werner syndrome and progeria fibroblasts

7 January 2021

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How bioinformatics can help reverse engineer human aging

7 January 2021

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

7 January 2021

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Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

7 January 2021

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

7 January 2021

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Li-Fraumeni syndrome--a molecular and clinical review

7 January 2021

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Germline p16 mutations in familial melanoma

7 January 2021

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7 January 2021

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Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer

7 January 2021

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Retinoblastoma: Clues to Human Oncogenesis

7 January 2021

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Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

7 January 2021

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Developmental and tissue-specific regulation of mouse telomerase and telomere length

7 January 2021

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Telomeres in cancer and aging: lessons from the mouse

7 January 2021

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p53 mutant mice that display early ageing-associated phenotypes

7 January 2021

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

7 January 2021

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7 January 2021

Dyskeratosis congenita

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Dyskeratosis Congenita (DC) Registry: identification of new features of DC.

7 January 2021

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Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

7 January 2021

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

7 January 2021

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Positive correlation between mammalian life span and cellular resistance to stress.

7 January 2021

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Duration of senescent cell survival in vitro as a characteristic of organism longevity, an additional to the proliferative potential of fibroblasts

7 January 2021

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Gene regulation and DNA damage in the ageing human brain

7 January 2021

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Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice

7 January 2021

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Tumor induction and tissue atrophy in mice lacking E2F-1

7 January 2021

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