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Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin.
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Europe PubMed Central
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3345530
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586367%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
title
Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin
(English)
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stated in
Europe PubMed Central
PMC publication ID
3345530
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586367%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
main subject
ivermectin
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author
Timothy Lynagh
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
3345530
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586367%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
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Joseph W Lynch
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2
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Europe PubMed Central
PMC publication ID
3345530
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1 February 2020
publication date
7 May 2012
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1 February 2020
published in
Frontiers in Molecular Neuroscience
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3345530
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1 February 2020
volume
5
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Europe PubMed Central
PMC publication ID
3345530
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1 February 2020
page(s)
60
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Europe PubMed Central
PMC publication ID
3345530
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586367%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
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27 July 2018
An amino acid substitution in the pore region of a glutamate-gated chloride channel enables the coupling of ligand binding to channel gating.
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A patch-clamp study of effects of dihydroavermectin on Ascaris muscle
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Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesis
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On the distribution of a fluorescent ivermectin probe (4″ 5,7 dimethyl-bodipy proprionylivermectin) in Ascaris membranes
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Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.
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27 July 2018
Synthesis of 5-keto-5-oxime derivatives of milbemycins and their activities against microfilariae
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Amino acid residues of both the extracellular and transmembrane domains influence binding of the antiparasitic agent milbemycin to Haemonchus contortus AVR-14B glutamate-gated chloride channels.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
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24 September 2018
A comparison of glycine- and ivermectin-mediated conformational changes in the glycine receptor ligand-binding domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: modulation by macrocyclic lactone anthelmintics and a receptor for piperazine.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
A point mutation in a glutamate-gated chloride channel confers abamectin resistance in the two-spotted spider mite, Tetranychus urticae Koch.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
The cys-loop ligand-gated ion channel gene superfamily of the parasitoid wasp, Nasonia vitripennis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
A comprehensive study on the 5-hydroxytryptamine(3A) receptor binding of agonists serotonin and m-chlorophenylbiguanidine.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Aplysia cys-loop glutamate-gated chloride channels reveal convergent evolution of ligand specificity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
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24 September 2018
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits from ivermectin-resistant Cooperia oncophora affect agonist sensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Comparison of ivermectin, doramectin, selamectin, and eleven intermediates in a nematode larval development assay
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Activation of rat recombinant alpha(1)beta(2)gamma(2S) GABA(A) receptor by the insecticide ivermectin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Environmental assessment of avermectins by the US Food and Drug Administration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Ivermectin for spasticity in spinal-cord injury.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Avermectin B1aModulation of ?-Aminobutyric Acid Receptors in Rat Brain Membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345530
retrieved
24 September 2018
Acetylcholine receptor channel imaged in the open state
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22586367
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FNMOL.2012.00060
1 reference
stated in
Europe PubMed Central
PMC publication ID
3345530
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PMC publication ID
3345530
1 reference
stated in
Europe PubMed Central
PMC publication ID
3345530
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PubMed publication ID
22586367
1 reference
stated in
Europe PubMed Central
PMC publication ID
3345530
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
ResearchGate publication ID
224958989
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