(Q36006981)

English

Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling

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scholarly article

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Europe PubMed Central

11 August 2017

Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling (English)

1 reference

Europe PubMed Central

11 August 2017

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

Nahum Sonenberg

16

object named as

Nahum Sonenberg

1 reference

Europe PubMed Central

11 August 2017

object named as

Andrew R Tee

11

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author name string

Bruno D Fonseca

1

1 reference

Europe PubMed Central

11 August 2017

Graham H Diering

2

1 reference

Europe PubMed Central

11 August 2017

Michael A Bidinosti

3

1 reference

Europe PubMed Central

11 August 2017

Kush Dalal

4

1 reference

Europe PubMed Central

11 August 2017

Tommy Alain

5

1 reference

Europe PubMed Central

11 August 2017

Aruna D Balgi

6

1 reference

Europe PubMed Central

11 August 2017

Roberto Forestieri

7

1 reference

Europe PubMed Central

11 August 2017

Matt Nodwell

8

1 reference

Europe PubMed Central

11 August 2017

Charles V Rajadurai

9

1 reference

Europe PubMed Central

11 August 2017

Cynthia Gunaratnam

10

1 reference

Europe PubMed Central

11 August 2017

Franck Duong

12

1 reference

Europe PubMed Central

11 August 2017

Raymond J Andersen

13

1 reference

Europe PubMed Central

11 August 2017

John Orlowski

14

1 reference

Europe PubMed Central

11 August 2017

Masayuki Numata

15

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Europe PubMed Central

11 August 2017

Michel Roberge

17

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11 August 2017

language of work or name

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publication date

2 April 2012

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Europe PubMed Central

11 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

11 August 2017

287

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Europe PubMed Central

11 August 2017

21

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Europe PubMed Central

11 August 2017

17530-17545

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Europe PubMed Central

11 August 2017

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Regulation of mTORC1 signaling by pH

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

1 reference

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2 October 2017

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

1 reference

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2 October 2017

Targeting the mTOR kinase domain: the second generation of mTOR inhibitors

1 reference

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2 October 2017

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

1 reference

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2 October 2017

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

1 reference

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2 October 2017

Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer

1 reference

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2 October 2017

Dissecting the role of mTOR: lessons from mTOR inhibitors

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2 October 2017

Sensors and regulators of intracellular pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth

1 reference

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2 October 2017

Fluorescent indicators for intracellular pH.

1 reference

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2 October 2017

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exercise

1 reference

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2 October 2017

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

1 reference

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2 October 2017

EGFR signals to mTOR through PKC and independently of Akt in glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

The role of TOR in autophagy regulation from yeast to plants and mammals

1 reference

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2 October 2017

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies

1 reference

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2 October 2017

eIF4E, the mRNA cap-binding protein: from basic discovery to translational research

1 reference

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2 October 2017

The Catalogue of Somatic Mutations in Cancer (COSMIC)

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2 October 2017

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

The selectivity of protein kinase inhibitors: a further update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Rapamycin: something old, something new, sometimes borrowed and now renewed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

New uses for old drugs

1 reference

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2 October 2017

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

1 reference

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2 October 2017

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Drugs, their targets and the nature and number of drug targets

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2 October 2017

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Finding new tricks for old drugs: an efficient route for public-sector drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Evolutionary origins of eukaryotic sodium/proton exchangers

1 reference

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2 October 2017

The AMP-activated protein kinase pathway--new players upstream and downstream.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

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2 October 2017

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Tuberous sclerosis complex: from Drosophila to human disease.

1 reference

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2 October 2017

TSC2: filling the GAP in the mTOR signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

1 reference

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2 October 2017

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors

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2 October 2017

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Identification of a conserved motif required for mTOR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

2 October 2017

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

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2 October 2017

Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.

1 reference

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2 October 2017

Inhibition of stimulated Jurkat cell adenosine 3',5'-cyclic monophosphate synthesis by the immunomodulatory compound HR325.

1 reference

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2 October 2017

17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes

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2 October 2017

Multiple genes at 17q23 undergo amplification and overexpression in breast cancer

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2 October 2017

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

1 reference

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2 October 2017

Fasciolicides: efficacy, actions, resistance and its management

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2 October 2017

Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution

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2 October 2017

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

1 reference

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2 October 2017

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

1 reference

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2 October 2017

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

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2 October 2017

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

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2 October 2017

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

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2 October 2017

Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases.

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2 October 2017

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

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2 October 2017

Pharmacokinetics of rapamycin

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2 October 2017

Transport of protons across membranes by weak acids

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2 October 2017

Cytoplasmic [Ca2+] and intracellular pH in lymphocytes. Role of membrane potential and volume-activated Na+/H+ exchange

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2 October 2017

Uncouplers of oxidative phosphorylation

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2 October 2017

Lysosomal positioning coordinates cellular nutrient responses.

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11 July 2018

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

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11 July 2018

The SecY complex forms a channel capable of ionic discrimination

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11 July 2018

High-level expression and detection of ion channels in Xenopus oocytes

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11 July 2018

Cell signaling. New mTOR targets Grb attention.

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23 September 2018

The pharmacology of mTOR inhibition

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23 September 2018

mTORC2 is the hydrophobic motif kinase for SGK1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

23 September 2018

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

23 September 2018

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

23 September 2018

Peptide-derivatized shell-cross-linked nanoparticles. 1. Synthesis and characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

23 September 2018

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

23 September 2018

Mode switching characterizes the activity of large conductance potassium channels recorded from rat cortical fused nerve terminals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366846

23 September 2018

Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential sensitivity of the cellular compartments of Saccharomyces cerevisiae to protonophoric uncoupler under fermentative and respiratory energy supply

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular acidification is not a prerequisite for glutamate-triggered death of cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of acid extrusion mechanisms in cultured fetal rat hippocampal neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propionate induces pH(i) changes through calcium flux, ERK1/2, p38, and PKC in bovine neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/22474287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.359638

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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