(Q36097816)

12 August 2017

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title

Human DNA topoisomerase I: relaxation, roles, and damage control (English)

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12 August 2017

John B Leppard

1

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PubMed ID

15830206

12 August 2017

James J Champoux

series ordinal

2

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12 August 2017

14 April 2005

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12 August 2017

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12 August 2017

114

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12 August 2017

75-85

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12 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s00412-005-0345-5

12 August 2017

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cites work

The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00412-005-0345-5

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00412-005-0345-5

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00412-005-0345-5

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

21 January 2018

1 reference

12 December 2020

The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction

1 reference

12 December 2020

Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status

1 reference

12 December 2020

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

1 reference

12 December 2020

Mitotic chromosome condensation in the rDNA requires TRF4 and DNA topoisomerase I in Saccharomyces cerevisiae.

1 reference

12 December 2020

Transcription-dependent degradation of topoisomerase I-DNA covalent complexes

1 reference

12 December 2020

Transcription by RNA polymerase I.

1 reference

12 December 2020

A novel nuclear localization signal in human DNA topoisomerase I

1 reference

12 December 2020

Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.

1 reference

12 December 2020

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

1 reference

12 December 2020

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

1 reference

12 December 2020

DNA topoisomerase I is essential in Drosophila melanogaster

1 reference

12 December 2020

Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro

1 reference

12 December 2020

Nuclear and unclear functions of SUMO

1 reference

12 December 2020

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

1 reference

12 December 2020

Changes in mobility account for camptothecin-induced subnuclear relocation of topoisomerase I.

1 reference

12 December 2020

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

1 reference

12 December 2020

The N-terminal domain anchors human topoisomerase I at fibrillar centers of nucleoli and nucleolar organizer regions of mitotic chromosomes

1 reference

12 December 2020

DNA topoisomerases: structure, function, and mechanism

1 reference

12 December 2020

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

1 reference

12 December 2020

An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay).

1 reference

12 December 2020

Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding

1 reference

12 December 2020

Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics.

1 reference

12 December 2020

Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA.

1 reference

12 December 2020

The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I

1 reference

12 December 2020

Preferential binding of human topoisomerase I to superhelical DNA.

1 reference

12 December 2020

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

1 reference

12 December 2020

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

1 reference

12 December 2020

Werner protein stimulates topoisomerase I DNA relaxation activity

1 reference

12 December 2020

Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein

1 reference

12 December 2020

Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases

1 reference

12 December 2020

Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures

1 reference

12 December 2020

A model for the mechanism of human topoisomerase I

1 reference

12 December 2020

Oxidative DNA damage background estimated by a system model of base excision repair

1 reference

12 December 2020

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

1 reference

12 December 2020

Spatial and temporal cellular responses to single-strand breaks in human cells.

1 reference

12 December 2020

Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.

1 reference

12 December 2020

8-Oxoguanine rearranges the active site of human topoisomerase I

1 reference

12 December 2020

Modulation of DNA Topoisomerase I Activity byp53

1 reference

12 December 2020

Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin

1 reference

12 December 2020

Live or let die: the cell's response to p53

1 reference

12 December 2020

Cell cycle analysis of amount and distribution of nuclear DNA topoisomerase I as determined by fluorescence digital imaging microscopy

1 reference

12 December 2020

Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells

1 reference

12 December 2020

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

1 reference

12 December 2020

Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II.

1 reference

12 December 2020

Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA

1 reference

12 December 2020

Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.

1 reference

12 December 2020

Essential functions of DNA topoisomerase I in Drosophila melanogaster

1 reference

12 December 2020

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

1 reference

12 December 2020

1 reference

12 December 2020

Human ARF protein interacts with topoisomerase I and stimulates its activity

1 reference

12 December 2020

Repair of DNA covalently linked to protein.

1 reference

12 December 2020

Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA

1 reference

12 December 2020

Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin

1 reference

12 December 2020

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

1 reference

12 December 2020

Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.

1 reference

12 December 2020

Human mitochondrial topoisomerase I

1 reference

12 December 2020

1 reference

12 December 2020

Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer

1 reference

12 December 2020

DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein

1 reference

12 December 2020

Identification of a nucleolin binding site in human topoisomerase I

1 reference

12 December 2020

Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

1 reference

12 December 2020

Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers

1 reference

12 December 2020

Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin

1 reference

12 December 2020

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

1 reference

12 December 2020

1 reference

12 December 2020

Tumor cell death induced by topoisomerase-targeting drugs.

1 reference

12 December 2020

A 17S multiprotein form of murine cell DNA polymerase mediates polyomavirus DNA replication in vitro

1 reference

12 December 2020

Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.

1 reference

12 December 2020

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin

1 reference

12 December 2020

Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.

1 reference

12 December 2020

Distinct in vivo dynamics of vertebrate SUMO paralogues

1 reference

12 December 2020

Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair

1 reference

12 December 2020

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

1 reference

12 December 2020

A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay

1 reference

12 December 2020

Down modulation of topoisomerase I affects DNA repair efficiency.

1 reference

12 December 2020

Reconstitution of human topoisomerase I by fragment complementation

1 reference

12 December 2020

RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I

1 reference

12 December 2020

Cellular roles of dna topoisomerases: a molecular perspective

1 reference

12 December 2020

PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli

1 reference

12 December 2020

Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase

1 reference

12 December 2020

Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function

1 reference

12 December 2020

Activation of topoisomerase I by poly [ADP-ribose] polymerase

1 reference

12 December 2020

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage

1 reference

12 December 2020

A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin.

1 reference

12 December 2020

Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan

1 reference

12 December 2020

Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels

1 reference

12 December 2020

DNA topoisomerase I is involved in both repression and activation of transcription

1 reference

12 December 2020

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

1 reference

12 December 2020

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

12 December 2020

10.1007/S00412-005-0345-5

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15830206