(Q36098356)

12 August 2017

SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling (English)

1 reference

12 August 2017

Daniel Abankwa

2

0 references

author name string

Elina Siljamäki

series ordinal

1

1 reference

12 August 2017

language of work or name

English

0 references

publication date

8 August 2016

1 reference

Molecular and Cellular Biology

12 August 2017

1 reference

12 August 2017

36

1 reference

12 August 2017

20

1 reference

12 August 2017

2612-2625

1 reference

describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5038144/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Cancer stem cell drugs target K-ras signaling in a stemness context

2 October 2017

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Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1.

2 October 2017

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K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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The developing story of Sprouty and cancer

2 October 2017

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The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering.

2 October 2017

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Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer

2 October 2017

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Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters

2 October 2017

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2 October 2017

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Allosteric activation of functionally asymmetric RAF kinase dimers

2 October 2017

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Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins

2 October 2017

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Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

2 October 2017

1 reference

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Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling

2 October 2017

1 reference

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It takes two to tango--signalling by dimeric Raf kinases

2 October 2017

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Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins.

2 October 2017

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The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase

2 October 2017

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2 October 2017

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A comprehensive survey of Ras mutations in cancer

2 October 2017

1 reference

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Raf inhibitors target ras spatiotemporal dynamics

2 October 2017

1 reference

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Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes

2 October 2017

1 reference

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Ras in cancer and developmental diseases

2 October 2017

1 reference

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Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism

2 October 2017

1 reference

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Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis

2 October 2017

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A high-resolution anatomical atlas of the transcriptome in the mouse embryo

2 October 2017

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

2 October 2017

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Mechanistic principles of RAF kinase signaling

2 October 2017

1 reference

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H-Ras nanocluster stability regulates the magnitude of MAPK signal output

2 October 2017

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Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth

2 October 2017

1 reference

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

2 October 2017

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

2 October 2017

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

2 October 2017

1 reference

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Ras membrane orientation and nanodomain localization generate isoform diversity

2 October 2017

1 reference

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Differential expression of immunomodulatory galectin-1 in peripheral leukocytes and adult tissues and its cytosolic organization in striated muscle

2 October 2017

1 reference

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The role of galectins in protein trafficking

2 October 2017

1 reference

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SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype

2 October 2017

1 reference

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SPRED1 germline mutations caused a neurofibromatosis type 1 overlapping phenotype.

2 October 2017

1 reference

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A novel switch region regulates H-ras membrane orientation and signal output

2 October 2017

1 reference

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Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Membrane phosphatidylserine regulates surface charge and protein localization

2 October 2017

1 reference

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Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Getting a first clue about SPRED functions

2 October 2017

1 reference

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A FRET map of membrane anchors suggests distinct microdomains of heterotrimeric G proteins

2 October 2017

1 reference

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Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival

2 October 2017

1 reference

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MAP kinase signalling pathways in cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Regulation and role of Raf-1/B-Raf heterodimerization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Eve-3: a liver enriched suppressor of Ras/MAPK signaling.

2 October 2017

1 reference

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2 October 2017

1 reference

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Gene disruption of Spred-2 causes dwarfism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Distinct requirements for the Sprouty domain for functional activity of Spred proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Expression and subcellular localization of Spred proteins in mouse and human tissues

2 October 2017

1 reference

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Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

2 October 2017

1 reference

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Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Ras proteins: different signals from different locations

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Transient gene expression: recombinant protein production with suspension-adapted HEK293-EBNA cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Spred is a Sprouty-related suppressor of Ras signalling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Active Ras induces heterodimerization of cRaf and BRaf

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Galectins: a family of animal beta-galactoside-binding lectins

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5038144

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27503857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.00191-16

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

27503857

1 reference