(Q36103191)

12 August 2017

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title

Telomere and telomerase as targets for anti-cancer and regeneration therapies (English)

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12 August 2017

1

Yi-hsin Hsu

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12 August 2017

2

Jing-jer Lin

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publication date

1 May 2005

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Acta Pharmacologica Sinica

12 August 2017

published in

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12 August 2017

volume

26

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12 August 2017

issue

5

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12 August 2017

page(s)

513-518

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https://scigraph.springernature.com/pub.10.1111/j.1745-7254.2005.00098.x

12 August 2017

exact match

0 references

cites work

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Telomeres shorten during ageing of human fibroblasts

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The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

21 January 2018

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

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A survey of telomerase activity in human cancer

21 January 2018

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Hallmarks of senescence in carcinogenesis and cancer therapy

21 January 2018

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Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

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Alternative lengthening of telomeres in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Telomerase: a target for cancer therapeutics

21 January 2018

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Switching and signaling at the telomere

21 January 2018

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Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

21 January 2018

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Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Mechanism of telomerase induction during T cell activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Telomerase maintains telomere structure in normal human cells.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

The RNA component of human telomerase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

21 January 2018

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Telomeres and telomerases as drug targets

21 January 2018

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Telomere maintenance as a target for anticancer drug discovery

21 January 2018

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Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

21 January 2018

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

21 January 2018

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A novel carbazole derivative, BMVC: a potential antitumor agent and fluorescence marker of cancer cells.

21 January 2018

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Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

21 January 2018

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Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative

21 January 2018

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

21 January 2018

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Mammalian telomeres end in a large duplex loop

21 January 2018

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Inhibition of telomerase by G-quartet DNA structures

21 January 2018

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Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts

21 January 2018

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Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

21 January 2018

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2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase

21 January 2018

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Molecular modelling and cytotoxicity of substituted anthraquinones as inhibitors of human telomerase

21 January 2018

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Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Regulation of the human telomerase reverse transcriptase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Telomerase is controlled by protein kinase Calpha in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Subnuclear shuttling of human telomerase induced by transformation and DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Adult human mesenchymal stem cell as a target for neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Constitutive telomerase expression promotes mammary carcinomas in aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Telomerase activation by histone deacetylase inhibitor in normal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Xenoantigen, an alphaGal epitope-expression construct driven by the hTERT-promoter, specifically kills human pancreatic cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Adenovirus-mediated suicide gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter induced apoptosis of ovarian cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

Telomerase as a universal tumor-associated antigen for cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2005.00098.X

10.1111/J.1745-7254.2005.00098.X

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

12 August 2017

1035208786

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1 reference