(Q34979724)

5 August 2017

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title

Telomerase: a target for cancer therapeutics (English)

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5 August 2017

2

Woodring E Wright

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5 August 2017

1

Jerry W Shay

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5 August 2017

publication date

1 October 2002

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5 August 2017

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5 August 2017

volume

2

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5 August 2017

issue

4

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5 August 2017

page(s)

257-265

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Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase regulation: not just flipping the switch

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere states and cell fates

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere length in myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere length in leukocyte subpopulations of patients with aplastic anemia

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere dynamics and telomerase activity in in vitro immortalised human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere elongation in immortal human cells without detectable telomerase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Mammalian telomeres and telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase in the human organism

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase: an unusual target for cytotoxic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase inhibition, oligonucleotides, and clinical trials

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Protection of mammalian telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

For better or worse? Telomerase inhibition and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

The RNA component of human telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Inhibition of Telomerase Activity by a Hammerhead Ribozyme Targeting the RNA Component of Telomerase in Human Melanoma Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Irreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Many ways to telomere dysfunction: in vivo studies using mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase in cancer and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Mammalian telomeres end in a large duplex loop

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase inhibitors--oligonucleotide phosphoramidates as potential therapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Cellular delivery of peptide nucleic acids and inhibition of human telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere loss: mitotic clock or genetic time bomb?

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase is not an oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere dysfunction: multiple paths to the same end.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase and telomeres: from basic biology to cancer treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Alternative lengthening of telomeres in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Molecular targeting of cancer: telomeres as targets

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Role of telomerase in cellular proliferation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Functional requirement of p23 and Hsp90 in telomerase complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Human is a unique species among primates in terms of telomere length.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase: biology and phase I trials

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase and chromosome end maintenance.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere maintenance without telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

An alternative pathway for yeast telomere maintenance rescues est1- senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

The relative quiescence of hematopoietic stem cells in nonhuman primates

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Connecting chromosomes, crisis, and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomeres and their control

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Applications of telomerase research in the fight against cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase catalytic subunit homologs from fission yeast and human

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere maintenance as a target for anticancer drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Inhibition of human telomerase activity by peptide nucleic acids

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

The telomerase reverse transcriptase: components and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Inhibition of human telomerase by 2'-O-methyl-RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Smart drugs: tyrosine kinase inhibitors in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

A survey of telomerase activity in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

The RB and p53 pathways in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Different telomere damage signaling pathways in human and mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Control of human telomere length by TRF1 and TRF2

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Senescence: does it all happen at the ends?

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Inhibition of human telomerase by a G-quadruplex-interactive compound

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomerase as a universal tumor-associated antigen for cancer immunotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900159-9

7 January 2021

10.1016/S1535-6108(02)00159-9

Identifiers

DOI

1 reference

5 August 2017

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