(Q36209145)

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Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

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scholarly article

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Europe PubMed Central

12 August 2017

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs (English)

1 reference

Europe PubMed Central

12 August 2017

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

Begoña Martin-Castillo

6

object named as

Begoña Martin-Castillo

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Europe PubMed Central

12 August 2017

author name string

Bruna Corominas-Faja

1

1 reference

Europe PubMed Central

12 August 2017

Rosa Quirantes-Piné

2

1 reference

Europe PubMed Central

12 August 2017

Cristina Oliveras-Ferraros

3

1 reference

Europe PubMed Central

12 August 2017

Alejandro Vazquez-Martin

4

1 reference

Europe PubMed Central

12 August 2017

Sílvia Cufí

5

1 reference

Europe PubMed Central

12 August 2017

Vicente Micol

7

1 reference

Europe PubMed Central

12 August 2017

Jorge Joven

8

1 reference

Europe PubMed Central

12 August 2017

Antonio Segura-Carretero

9

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Europe PubMed Central

12 August 2017

Javier A Menendez

10

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Europe PubMed Central

12 August 2017

publication date

1 July 2012

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Europe PubMed Central

12 August 2017

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Europe PubMed Central

12 August 2017

4

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Europe PubMed Central

12 August 2017

480-498

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Europe PubMed Central

12 August 2017

7

1 reference

Europe PubMed Central

12 August 2017

Distinct perturbation of the translatome by the antidiabetic drug metformin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts

1 reference

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1 October 2017

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

1 reference

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1 October 2017

Trafficking of intracellular folates

1 reference

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1 October 2017

Cancer metabolism: current perspectives and future directions

1 reference

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1 October 2017

Metformin: multi-faceted protection against cancer

1 reference

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1 October 2017

Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer

1 reference

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1 October 2017

Pilot study of a pediatric metronomic 4-drug regimen

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1 October 2017

Metformin and cancer therapy.

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1 October 2017

Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people

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1 October 2017

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

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1 October 2017

Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection

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1 October 2017

The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases

1 reference

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1 October 2017

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

1 reference

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1 October 2017

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

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1 October 2017

UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model

1 reference

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1 October 2017

Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

1 reference

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1 October 2017

Gerosuppressant metformin: less is more

1 reference

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1 October 2017

Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers

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1 October 2017

Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture

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1 October 2017

Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates

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1 October 2017

Sensing of energy and nutrients by AMP-activated protein kinase.

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1 October 2017

Integrated analysis of ATM mediated gene and protein expression impacting cellular metabolism.

1 reference

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1 October 2017

Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma

1 reference

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1 October 2017

The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling

1 reference

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1 October 2017

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Metformin activates AMP kinase through inhibition of AMP deaminase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

How does methotrexate suppress inflammation?

1 reference

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1 October 2017

Inflammatory signaling pathways in self-renewing breast cancer stem cells.

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1 October 2017

Treatment of polycystic ovary syndrome (PCOS) with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Metformin: taking away the candy for cancer?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Metronomic chemotherapy: new rationale for new directions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Systemic DNA damage response and metabolic syndrome as a premalignant state

1 reference

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1 October 2017

Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients

1 reference

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1 October 2017

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Pharmacometabolomics of docetaxel-treated human MCF7 breast cancer cells provides evidence of varying cellular responses at high and low doses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK activation and induces senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

One-carbon metabolism and breast cancer: an epidemiological perspective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

New metabolites of fenofibrate in Sprague-Dawley rats by UPLC-ESI-QTOF-MS-based metabolomics coupled with LC-MS/MS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Somatic LKB1 mutations promote cervical cancer progression

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1 October 2017

Molecular formula and METLIN Personal Metabolite Database matching applied to the identification of compounds generated by LC/TOF-MS

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

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1 October 2017

B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer

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1 October 2017

Modeling folate, one-carbon metabolism, and DNA methylation

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1 October 2017

A sample extraction and chromatographic strategy for increasing LC/MS detection coverage of the erythrocyte metabolome

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1 October 2017

Adenosine and adenosine receptors in the pathomechanism and treatment of respiratory diseases.

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1 October 2017

A mathematical model of glutathione metabolism

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1 October 2017

Brick by brick: metabolism and tumor cell growth

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1 October 2017

Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II.

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1 October 2017

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

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1 October 2017

AMP activated protein kinase: a next generation target for total metabolic control.

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1 October 2017

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

1 October 2017

Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.

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1 October 2017

AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner

1 reference

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1 October 2017

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

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1 October 2017

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

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1 October 2017

Caffeine markedly sensitizes human mesothelioma cell lines to pemetrexed

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1 October 2017

Folate and cancer--timing is everything

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1 October 2017

Folic Acid for the Prevention of Colorectal Adenomas

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1 October 2017

Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration

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1 October 2017

Metronomic chemotherapy: an antiangiogenic scheduling

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1 October 2017

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

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1 October 2017

Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways

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1 October 2017

Nucleotide metabolism and cell-cell interactions

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1 October 2017

AMP-activated protein kinase and type 2 diabetes

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1 October 2017

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

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1 October 2017

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner

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1 October 2017

Physiology of folate and vitamin B12 in health and disease

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1 October 2017

The anti-angiogenic basis of metronomic chemotherapy

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1 October 2017

Anticancer Antifolates: Current Status and Future Directions

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1 October 2017

The Crabtree effect: a review

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1 October 2017

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

1 reference

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1 October 2017

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

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1 October 2017

Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis

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1 October 2017

The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes

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1 October 2017

Folic acid: nutritional biochemistry, molecular biology, and role in disease processes

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1 October 2017

Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin

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1 October 2017

Folate administration reduces circulating homocysteine levels in NIDDM patients on long-term metformin treatment

1 reference

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1 October 2017

Folate and antifolate pharmacology.

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1 October 2017

Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment

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1 October 2017

The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus

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29 June 2018

Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?

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29 June 2018

Metformin increases total serum homocysteine levels in non-diabetic male patients with coronary heart disease.

1 reference

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29 June 2018

Metformin and B-12 Malabsorption

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

29 June 2018

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

29 June 2018

Interaction between methotrexate, "rescue" agents and cell proliferation as modulators of homocysteine export from cells in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

29 June 2018

Metformin interacts with AMPK through binding to γ subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics--a pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

The role of ATM in response to metformin treatment and activation of AMPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

The role of ATM in response to metformin treatment and activation of AMPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Metformin and energy metabolism in breast cancer: from insulin physiology to tumour-initiating stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Methotrexate--how does it really work?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Metformin, B(12), and enhanced breast cancer response to chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Mathematical models of folate-mediated one-carbon metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Metformin-related vitamin B12 deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Metformin prevents endotoxin-induced liver injury after partial hepatectomy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Vitamin B 12 and metformin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433934

22 September 2018

Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of ATM in response to metformin treatment and activation of AMPK

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of thymidine and hypoxanthine rescue from MTA (LY231514) growth inhibition by dipyridamole in human lung cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cellular energy metabolism: the Crabtree effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the biguanide class of oral hypoglycemic agents on mouse embryogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin and the fate of fat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neither LKB1 nor AMPK are the direct targets of metformin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin B12 deficiency in patients receiving metformin: clinical data

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22837425

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/AGING.100472

0 references

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

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