(Q36300027)

13 August 2017

1 reference

title

Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants (English)

1 reference

13 August 2017

Guang-Yi Zhang

1

1 reference

PubMed ID

16255677

13 August 2017

Quan-Guang Zhang

series ordinal

2

1 reference

PubMed ID

16255677

13 August 2017

language of work or name

English

0 references

publication date

1 November 2005

1 reference

Expert Opinion on Investigational Drugs

13 August 2017

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13 August 2017

14

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13 August 2017

1373-1383

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13 August 2017

11

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Mammalian MAP kinase signalling cascades

13 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

From receptors to stress-activated MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Role of mitogen- and stress-activated kinases in ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Protein kinase cascades activated by stress and inflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Signaling through scaffold, anchoring, and adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

The JIP group of mitogen-activated protein kinase scaffold proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Repression of phospho-JNK and infarct volume in ischemic brain of JIP1-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

21 January 2018

A convoluted way to die.

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Apoptosis signaling by death receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Conformation-dependent phosphorylation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Sounding the alarm: protein kinase cascades activated by stress and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Transcription factor ATF2 regulation by the JNK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Mitochondrial involvement in the point of no return in neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Chemical-induced apoptosis: formation of the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Transient cerebral ischemia induces delayed proapoptotic Bad translocation to mitochondria in CA1 sector of hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Ischemia leads to apoptosis--and necrosis-like neuron death in the ischemic rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Activation and autophosphorylation of apoptosis signal-regulating kinase 1 (ASK1) following cerebral ischemia in rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Antioxidant N-acetylcysteine and AMPA/KA receptor antagonist DNQX inhibited mixed lineage kinase-3 activation following cerebral ischemia in rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Extracellular signal-regulated kinase and c-Jun N-terminal protein kinase in ischemic tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

c-Jun N-terminal kinase activation in hippocampal CA1 region was involved in ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Kinetics of trkA tyrosine kinase activity and inhibition by K-252a

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Targeting the JNK pathway for therapeutic benefit in CNS disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Targeting JNK3 for the treatment of neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Targeting JNK for therapeutic benefit: from junk to gold?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Mixed-lineage kinases: a target for the prevention of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurones following global transient ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

A mammalian scaffold complex that selectively mediates MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Identification of the critical features of a small peptide inhibitor of JNK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

In vivo protein transduction: delivery of a biologically active protein into the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Transduction peptides: from technology to physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Antisense strategies in neurobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Antisense oligodeoxynucleotide and ribozyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Selective down-regulation of c-jun gene expression by pentoxifylline and c-jun antisense interrupts platelet-derived growth factor signaling: pentoxifylline inhibits phosphorylation of c-Jun on serine 73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

The AP-1 transcription factor c-Jun is required for efficient axonal regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

Stress-activated protein kinases-tumor suppressors or tumor initiators?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1373

10.1517/13543784.14.11.1373

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16255677